Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stress

Behavioural Brain Research

Volumn 167, Issue 2, 2006, Pages 270-286

  Adamec, Robert ^a   Strasser, Kirby ^a   Blundell, Jacqueline ^a   Burton, Paul ^a   McKay, Donald W ^b  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Anisomycin; Anxiety; Chloradiazepoxide; Consolidation; Corticosterone; Glucorticoid receptors; Plus maze; Predator stress; Reconsolidation; RU486; Startle

Indexed keywords

ANISOMYCIN; BENZODIAZEPINE; CORTICOSTERONE; CYTIDINE DIPHOSPHATE; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE;

ANIMAL BEHAVIOR; ANXIETY; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; MALE; MAZE TEST; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RISK ASSESSMENT; STARTLE REFLEX; STRESS; TRANQUILIZING ACTIVITY;

ANALYSIS OF VARIANCE; ANIMALS; ANISOMYCIN; ANTI-ANXIETY AGENTS; ANXIETY; ASSOCIATION LEARNING; CATS; CHLORDIAZEPOXIDE; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; HABITUATION, PSYCHOPHYSIOLOGIC; HORMONE ANTAGONISTS; MALE; MEMORY; MIFEPRISTONE; PREDATORY BEHAVIOR; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; RECEPTORS, GLUCOCORTICOID; SEVERITY OF ILLNESS INDEX; STARTLE REACTION; STRESS, PSYCHOLOGICAL;

EID: 30744447453     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2005.09.019     Document Type: Article

References (120)

1. R. Adamec Transmitter systems involved in neural plasticity underlying increased anxiety and defense - implications for understanding anxiety following traumatic stress Neurosci Biobehav Rev 21 6 1997 755 765
2. R. Adamec Does long term potentiation in periacqueductal gray (PAG) mediate lasting changes in rodent ALB produced by predator stress? - effects of low frequency stimulation (LFS) of PAG on place preference and changes in ALB produced by predator stress Behav Brain Res 120 2001 111 135
3. Adamec R, Blundell J, Burton P., Neural circuit changes mediating lasting brain and behavioral response to predator stress. Neurosci Biobehav Rev; in press.
4. Adamec R, Blundell J, Burton P. Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response. Neurosci Biobehav Rev; in press.
5. R. Adamec, J. Blundell, and Burton P Role of NMDA receptors in the lateralized potentiation of amygdala afferent and efferent neural transmission produced by predator stress Physiol. Behav. 86 2005 75 91
6. R. Adamec, J. Blundell, and A. Collins Neural plasticity and stress induced changes in defense in the rat Neurosci Biobehav Rev 25 2001 721 744
7. R. Adamec, J. Blundell, K. Strasser, and P. Burton Mechanisms of lasting change in anxiety induced by severe stress N. Sato R. Pitman PTSD: brain mechanisms and clinical implications 2005 Springer-Verlag Tokyo
8. R. Adamec, P. Kent, H. Anisman, T. Shallow, and Z. Merali Neural plasticity, neuropeptides and anxiety in animals - implications for understanding and treating affective disorder following traumatic stress in humans Neurosci Biobehav Rev 23 2 1998 301 318
9. R.E. Adamec Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 1. Role of NMDA receptors in efferent transmission from the cat amygdala J Psychopharmacol 12 2 1998 122 128
10. R.E. Adamec Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 2. The effects on behavior of block of NMDA receptors prior to injection of FG-7142 J Psychopharmacol 12 2 1998 129 136
11. R.E. Adamec Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 3. The effects on amygdala efferent physiology of block of NMDA receptors prior to injection of FG-7142 and its relationship to behavioral change J Psychopharmacol 12 3 1998 227 238
12. R.E. Adamec Lasting effects of FG-7142 on anxiety, aggression and limbic physiology in the cat J Psychopharmacol 7 1993 232 248
13. R.E. Adamec Evidence that limbic neural plasticity in the right hemisphere mediates partial kindling induced lasting increases in anxiety-like behavior: effects of low frequency stimulation (quenching?) on long term potentiation of amygdala efferents and behavior following kindling Brain Res 839 1 1999 133 152
14. R.E. Adamec, P. Burton, T. Shallow, and J. Budgell NMDA receptors mediate lasting increases in anxiety-like behavior produced by the stress of predator exposure - implications for anxiety associated with posttraumatic stress disorder Physiol Behav 65 4/5 1999 723 737
15. R.E. Adamec, P. Burton, T. Shallow, and J. Budgell Unilateral block of NMDA receptors in the amygdala prevents predator stress-induced lasting increases in anxiety-like behavior and unconditioned startle - effect on behavior depends on the hemisphere Physiol Behav 65 4/5 1999 739 751
16. R.E. Adamec, and T. Shallow Lasting effects on rodent anxiety of a single exposure to a cat Physiol Behav 54 1993 101 109
17. R.E. Adamec, T. Shallow, and J. Budgell Blockade of CCK(B) but not CCK(A) receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: implications for anxiety associated with posttraumatic stress disorder Behav Neurosci 111 2 1997 435 449
18. R. Adamec, G.D. Bartoszyk, and P. Burton Effects of systemic injections of Vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats Eur J Pharmacol 504 1/2 2004 65 77
19. R. Adamec, K. Creamer, G.D. Bartoszyk, and P. Burton Prophylactic and therapeutic effects of acute systemic injections of EMD 281014 a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats Eur J Pharmacol 504 1/2 2004 79 96
20. R.E. Adamec Stress effects on limbic function and behavior Prog Neuropsychopharmacol Biol Psychiat 27 8 2003 1173 1175
21. R.E. Adamec, J. Blundell, and P. Burton Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticity Prog Neuropsychopharmacol Biol Psychiat 27 8 2003 1243 1267
22. J.D. Baker, and J.L. Azorlosa The NMDA antagonist MK-801 blocks the extinction of pavlovian fear conditioning Behav Neurosci 110 3 1996 618 620
23. A. Barco, J.M. Alarcon, and E.R. Kandel Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture Cell 108 5 2002 689 703
24. E.J. Barea-Rodriguez, D.T. Rivera, D.B. Jaffe, and J.L. Martinez Jr. Protein synthesis inhibition blocks the induction of mossy fiber long-term potentiation in vivo J Neurosci 20 22 2000 8528 8532
25. E.P. Bauer, J.E. Ledoux, and K. Nader Fear conditioning and LTP in the lateral amygdala ave sensitive to the same stimulus contingencies Nat Neurosci 4 7 2001 687 688
26. E.P. Bauer, G.E. Schafe, and J.E. Ledoux NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala J Neurosci 22 12 2002 5239 5249
27. 3 receptor antagonist, in two animal models of anxiety Eur J Pharmacol 218 1992 327 334
28. P. Birmes, D. Carreras, and J.L. Ducasse Peritraumatic dissociation, acute stress, and early posttraumatic stress disorder in victims of general crime Can J Psychiat 46 7 2001 649 651
29. H.T. Blair, G.E. Schafe, E.P. Bauer, S.M. Rodrigues, and J.E. Ledoux Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning Learn Mem 8 5 2001 229 242
30. R.J. Blanchard, J.N. Nikulina, R.R. Sakai, C. McKittrick, B. McEwen, and D.C. Blanchard Behavioral and endocrine change following chronic predatory stress Physiol Behav 63 4 1998 561 569
31. W.H. Butler The neuropathology of vigabatrin Epilepsia [EIX] 30 Suppl 3 1989 S15 S17
32. S. Campeau, M.J.D. Miserendino, and M. Davis Intra-amygdala infusion of the N-methyl-d-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus Behav Neurosci 106 1992 569 574
33. P. Carrive, J. Lee, and A. Su Lidocaine blockade of amygdala output in fear-conditioned rats reduces fos expression in the ventrolateral periaqueductal gray Neuroscience 95 4 2000 1071 1080
34. H. Cohen, J. Zohar, and M. Matar The relevance of differential response to trauma in an animal model of posttraumatic stress disorder Biol Psychiat 53 6 2003 463 473
35. J.F. Crivello, and C.R. Jefcoate Mechanisms of corticotropin action in rat adrenal cells. I. The effects of inhibitors of protein synthesis and of microfilament formation on corticosterone synthesis Biochim Biophys Acta 542 2 1978 315 329
36. S. Das, M. Grunert, L. Williams, and S.R. Vincent NMDA and Dl receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture Synapse 25 3 1997 227 233
37. R.J. Davidson, D. Pizzagalli, J.B. Nitschke, and K. Putnam Depression: perspectives from affective Neurosci Annu Rev Psychol 53 2002 545 574
38. H.P. Davis, M.R. Rosenzweig, E.L. Bennett, and L.R. Squire Inhibition of cerebral protein synthesis: Dissociation of nonspecific effects and amnesic effects Behav Neural Biol 28 1 1980 99 104
39. H.P. Davis, M.R. Rosenzweig, E.L. Bennett, and L.R. Squire Inhibition of cerebral protein synthesis: dissociation of nonspecific effects and amnesic effects Behav Neural Biol 28 1 1980 99 104
40. H.P. Davis, M.R. Rosenzweig, P.T. Kinkade, and E.L. Bennett Effects of anisomycin on retention of the passive-avoidance habit as a function of age Exp Aging Res 7 1 1981 33 44
41. H.P. Davis, and L.R. Squire Protein synthesis and memory: a review Psychol Bull 96 3 1984 518 559
42. M. Davis, and N.M.D. Role of A receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy Eur J Neurosci 16 3 2002 395 398
43. M. Davis, and C. Shi The extended amygdala: are the central nucleus of the amygdala and the bed nucleus of the stria terminalis differentially involved in fear versus anxiety? Ann NY Acad Sci 877 1999 281 291
44. S.F. De Boer, J.L. Slangen, and G.J. van der Plasma catecholamine and corticosterone levels during active and passive shock-prod avoidance behavior in rats: effects of chlordiazepoxide Physiol Behav 47 6 1990 1089 1098
45. S.F. De Boer, J.L. Slangen, and G.J. van der Effects of buspirone and chlordiazepoxide on plasma catecholamine and corticosterone levels in stressed and nonstressed rats Pharmacol Biochem Behav 38 2 1991 299 308
46. S.F. De Boer, G.J. van der, and J.L. Slangen Effects of chlordiazepoxide, flumazenil and DMCM on plasma catecholamine and corticosterone concentrations in rats Pharmacol Biochem Behav 38 1 1991 13 19
47. J. Debiec, J.E. Ledoux, and K. Nader Cellular and systems reconsolidation in the hippocampus Neuron 36 3 2002 527 538
48. J.P. Decola, J.J. Kim, and M.S. Fanselow NMDA antagonist MK-801 blocks associative fear conditioning but not nonassociative sensitization of conditional fear Soc Neurosci Abstr 1991 17
49. R.A. Dielenberg, P. Carrive, and I.S. McGregor The cardiovascular and behavioral response to cat odor in rats: unconditioned and conditioned effects Brain Res 897 1/2 2001 228 237
50. B.M. Elzinga, and J.D. Bremner Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)? J Affect Dis 70 1 2002 1 17
51. M.S. Fanselow, J.J. Kim, and J. Yipp Differential reduction of fear conditioning to contextual and auditory conditional stimuli by ICV administration of an NMDA antagonist Soc Neurosci Abstr 1992 18
52. S.E. File The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs J Neurosci Meth 2 3 1980 219 238
53. S.E. File The contribution of behavioural studies to the neuropharmacology of anxiety Neuropharmacol 26 1987 877 886
54. S.E. File, and A.G. Wardill The reliability of the hole-board apparatus Psychopharmacologia 44 1 1975 47 51
55. S.E. File, and A.G. Wardill Validity of head-dipping as a measure of exploration in a modified hole-board Psychopharmacologia 44 1 1975 53 59
56. K.A. Goosens, and S. Maren Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning Hippocampus 12 5 2002 592 599
57. J. Hall, K.L. Thomas, and B.J. Everitt Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala Eur J Neurosci 13 7 2001 1453 1458
58. M. Hascoet, M. Bourin, and B.A.N. Dhonnchadha The mouse light-dark paradigm: a review Prog Neuropsychopharmacol Biol Psychiat 25 1 2001 141 166
59. F. Holsboer Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy J Affect Dis 62 1/2 2001 77 91
60. Y.Y. Huang, K.C. Martin, and E.R. Kandel Both protein kinase a and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation J Neurosci 20 17 2000 6317 6325
61. L.M. Igaz, M.R. Vianna, J.H. Medina, and I. Izquierdo Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning J Neurosci 22 15 2002 6781 6789
62. J.F. Ikin, M.R. Sim, and M.C. Creamer War-related psychological stressors and risk of psychological disorders in Australian veterans of the 1991 Gulf War Brit J Psychiat 185 2004 116 126
63. M.E. Keck, and F. Holsboer Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders Peptides 22 5 2001 835 844
64. R.C. Kessler, K.A. McGonagle, and S. Zhao Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States Results from the National Comorbidity Survey Arch Gen Psychiat 51 1 1994 8 19
65. R.C. Kessler, A. Sonnega, E. Bromet, M. Hughes, and C.B. Nelson Posttraumatic stress disorder in the National Comorbidity Survey Arch Gen Psychiat 52 12 1991 1048 1060
66. J.J. Kim, J.P. Decola, J. Landeira-Fernandez, and M.S. Fanselow N-methyl-d-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning Behav Neurosci 105 1991 126 133
67. V. Korz, and J.U. Frey Stress-related modulation of hippocampal long-term potentiation in rats: involvement of adrenal steroid receptors J Neurosci 23 19 2003 7281 7287
68. H. Lee, and J.J. Kim Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats J Neurosci 18 20 1998 8444 8454
69. H.J. Lee, J.S. Choi, T.H. Brown, and J.J. Kim Amygdalar NMDA receptors are critical for the expression of multiple conditioned fear responses J Neurosci 21 11 2001 4116 4124
70. O.K. Lee, C.J. Lee, and S. Choi Induction mechanisms for L-LTP at thalamic input synapses to the lateral amygdala: requirement of mGluR5 activation NeuroReport 13 5 2002 685 691
71. R. Macdonald, and J.L. Barker Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones Nature 271 5645 1978 563 564
72. S. Malkani, and J.B. Rosen Differential expression of EGR-1 mRNA in the amygdala following diazepam in contextual fear conditioning Brain Res 860 1/2 2000 53 63
73. S. Malkani, and J.B. Rosen Specific induction of early growth response gene I in the lateral nucleus of the amygdala following contextual fear conditioning in rats Neuroscience 97 4 2000 693 702
74. S. Maren, B. De Oca, and M.S. Fanselow Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning Brain Res 661 1994 25 34
75. S. Maren, and M.S. Fanselow Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo J Neurosci 15 1995 7548 7564
76. I.S. McGregor, L. Schrama, P. Ambermoon, and R.A. Dielenberg Not all 'predator odours' are equal: cat odour but not 2,4,5-trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats Behav Brain Res 129 1/2 2002 1 16
77. K.M. Myers, and M. Davis Behavioral and neural analysis of extinction Neuron 36 4 2002 567 584
78. K. Nader, G.E. Schafe, and J.E. Le Doux Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval Nature 406 6797 2000 722 726
79. K. Nader, G.E. Schafe, and J.E. Le Doux Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval Nature 406 6797 2000 722 726
80. K. Nader, G.E. Schafe, and J.E. Ledoux The labile nature of consolidation theory Nat Rev Neurosci 1 3 2000 216 219
81. J.N. Nestoros Benzodiazepine and gaba receptors are functionally related: further electrophysiological evidence in vivo Prog Neuropsychopharmacol Biol Psychiat 6 4-6 1982 417 420
82. K. Okamoto, and Y. Sakai Augmentation by chlordiazepoxide of the inhibitory effects of taurine, beta-alanine and gamma-aminobutyric acid on spike discharges in guinea-pig cerebellar slices Br J Pharmacol 65 2 1979 277 285
83. P. Okulski, G. Hess, and L. Kaczmarek Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala Neuroscience 114 1 2002 1 5
84. S.P. Orr, N.B. Lasko, L.J. Metzger, and R.K. Pitman Physiologic responses to non-startling tones in Vietnam veterans with post-traumatic stress disorder Psychiat Res 73 1/2 1997 103 107
85. S.P. Orr, N.B. Lasko, A.Y. Shalev, and R.K. Pitman Physiologic responses to loud tones in Vietnam veterans with posttraumatic stress disorder J Abnorm Psychol 104 1 1995 75 82
86. S.P. Orr, Z. Solomon, T. Peri, R.K. Pitman, and A.Y. Shalev Physiologic responses to loud tones in Israeli veterans of the 1973 Yom Kippur War Biol Psychiat 41 3 1997 319 326
87. F. Petty GABA and mood disorders: a brief review and hypothesis J Affect Dis 34 1995 275 281
88. R.K. Pitman Overview of biological themes in PTSD Ann NY Acad Sci 821 1997 1 9
89. R.K. Pitman, K.M. Sanders, and R.M. Zusman Pilot study of secondary prevention of posttraumatic stress disorder with propranolol Biol Psychiat 51 2 2002 189 192
90. S. Rauch, B.A. van der Kolk, and R.E. Fisler A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery Arch Gen Psychiat 53 5 1997 380 387
91. S. Ribeiro, C.V. Mello, T. Velho, T.J. Gardner, E.D. Jarvis, and C. Pavlides Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep J Neurosci 22 24 2002 10914 10923
92. R.J. Rodgers, and J.C. Cole Anxiety enhancement in the murine elevated plus maze by immediate prior exposure to social stressors Physiol Behav 53 1993 383 388
93. R.J. Rodgers, and N.J.T. Johnson Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety Pharmacol Biochem Behav 52 1995 297 303
94. M.T. Rogan, U.V. Staubli, and J.E. Ledoux Fear conditioning induces associative long-term potentiation in the amygdala Nature 390 6660 1997 604 607
95. B. Roozendaal, G.L. Quirarte, and J.L. McGaugh Stress-activated hormonal systems and the regulation of memory storage Ann NY Acad Sci 821 1997 247 258
96. J.B. Rosen, R.E. Adamec, and B.L. Thompson Expression of egr-1 (zif268) mRNA in select fear-related brain regions following exposure to a predator Behav Brain Res 162 2 2005 279 288
97. S. Royer, and D. Pare Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses Neuroscience 115 2 2002 455 462
98. G.E. Schafe, C.M. Atkins, M.W. Swank, E.P. Bauer, J.D. Sweatt, and J.E. Ledoux Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning J Neurosci 20 21 2000 8177 8187
99. G.E. Schafe, and J.E. Ledoux Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala J Neurosci 20 18 2000 NIL5 NIL9
100. G.E. Schafe, and J.E. Ledoux Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala J Neurosci 20 18 2000 RC96
101. G.E. Schafe, K. Nader, H.T. Blair, and J.E. Ledoux Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective TINS 24 9 2001 540 546
102. U. Schnyder, H. Moergeli, O. Trentz, R. Klaghofer, and C. Buddeberg Prediction of psychiatric morbidity in severely injured accident victims at one-year follow-up Am J Respir Crit Care Med 164 4 2001 653 656
103. C.N. Scholfield Ro 15-1788 is a potent antagonist of benzodiazepines in the olfactory cortex slice Pflugers Arch 396 4 1983 292 296
104. A.Y. Shalev, S. Freedman, T. Peri, D. Brandes, and T. Sahar Predicting PTSD in trauma survivors: prospective evaluation of self-report and clinician-administered instruments Brit J Psychiat 170 6 1997 558 564
105. A.Y. Shalev, S. Freedman, and T. Peri Prospective study of posttraumatic stress disorder and depression following trauma Am J Psychiat 155 5 1998 630 637
106. K. Shimosato, T. Saito, and R.J. Marley Genotype-specific blockade of cocaine-induced weight loss by the protein synthesis inhibitor, anisomycin Life Sci 55 16 1994 L293 L299
107. L.M. Shin, R.J. McNally, and S.M. Kosslyn A positron emission tomographic study of symptom provocation in PTSD Ann NY Acad Sci 821 1997 521 523
108. A.J. Silva, J.H. Kogan, P.W. Frankland, and S. Kida CREB and memory Annu Rev Neurosci 21 1998 127 148
109. A.J. Silva, and G.G. Murphy cAMP and memory: a seminal lesson from Drosophila and Aplysia Brain Res Bull 50 5/6 1999 441 442
110. M. Stanciu, J. Radulovic, and J. Spiess Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning: relationship to Fos production Mol Brain Res S 94 1/2 2001 15 24
111. O. Stiedl, K. Birkenfeld, M. Palve, and J. Spiess Impairment of conditioned contextual fear of C57BL/6J mice by intracerebral injections of the NMDA receptor antagonist APV Behav Brain Res 116 2 2000 157 168
112. C. Tardin, L. Cognet, C. Bats, B. Lounis, and D. Choquet Direct imaging of lateral movements of AMPA receptors inside synapses EMBO J 22 18 2003 4656 4665
113. E. Tsvetkov, W.A. Carlezon, F.M. Benes, E.R. Kandel, and V.Y. Bolshakov Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala Neuron 34 2 2002 289 300
114. G. Vaiva, F. Ducrocq, and K. Jezequel Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma Biol Psychiat 54 9 2003 947 949
115. H.D. Veldhuis, C.C. De Korte, and E.R. De Kloet Glucocorticoids facilitate the retention of acquired immobility during forced swimming Eur J Pharmacol 115 2/3 1985 211 217
116. D.L. Walker, and M. Davis Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear J Neurosci 17 23 1997 9375 9383
117. L. Xu, C. Holscher, R. Anwyl, and M.J. Rowan Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress Proc Natl Acad Sci USA 95 6 1998 3204 3208
118. H. Zangrossi Jr., and S.E. File Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor Brain Res Bull 29 1992 381 388
119. S.E. File, R.G. Lister, and D.J. Nutt Intrinsic actions of benzodiazepine autagonists Neurosci Lett 32 1982 165 168
120. G.A. Kennett, F. Bright, B. Trail, G.S. Baxter, and T.P. Blackburn Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety Br J Pharmacol 117 1996 1443 1448