11q22.3 deletion in B-chronic lymphocytic leukemia is specifically associated with bulky lymphadenopathy and ZAP-70 expression but not reduced expression of adhesion/cell surface receptor molecules

Leukemia and Lymphoma

Volumn 47, Issue 2, 2006, Pages 231-244

  Dickinson, John D ^a   Gilmore, Jamie ^c   Iqbal, Javeed ^b   Sanger, Warren ^a   Lynch, James C ^a   Chan, John ^b   Bierman, Philip J ^a   Joshi, Shantaram S ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

Author keywords

Chromosome abnormalities; CLL; Correlation analysis; Gene expression array; ZAP 70

Indexed keywords

CD38 ANTIGEN; CD7 ANTIGEN; CD79A ANTIGEN; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; CHEMOKINE; CHEMOKINE LIGAND 17; CHEMOKINE RECEPTOR CCR6; GENE PRODUCT; HERMES ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; LIGAND; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR C; RECEPTOR PROTEIN; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG;

ARTICLE; B CELL LEUKEMIA; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; LYMPHADENOPATHY; LYMPHOCYTE ACTIVATION; MALE; MEDIASTINUM LYMPH NODE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TRISOMY 12;

CELL ADHESION MOLECULES; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, B-CELL, CHRONIC; LYMPHATIC DISEASES; MALE; RECEPTORS, CELL SURFACE; TRISOMY; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 30644456577     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190500254141     Document Type: Article

References (45)

1. Dohner, H and Stilgenbauer, S and Benner, A and Leupolt, E and Krober, A and Bullinger, L and (2000) Genomic aberrations and survival in chronic lymphocytic leukemia N Engl J Med, 343, pp. 1910 - 1916.
2. Dohner, H and Stilgenbauer, S and Dohner, K and Bentz, M and Lichter, P. (1999) Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis J Mol Med, 77, pp. 266 - 281.
3. Sadamori, N and Han, T and Minowada, J and Sandberg, A. (1984) Clinical significance of cytogenetic findings in untreated patients with B-cell chronic lymphocytic leukemia Cancer Genet Cytogenet, 11, pp. 45 - 51.
4. Oscier, D and Stevens, J and Hamblin, T and Pickering, R and Lambert, R and Fitchett, M. (1990) Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia Br J Haematol, 76, pp. 352 - 358.
5. Aoun, P and Blair, H and Smith, L and Dave, B and Lynch, J and Weisenburger, D and (2004) Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma Leuk Lymphoma, 45, pp. 1595 - 1603.
6. Dewald, G and Brockman, S and Paternoster, S and Bone, N and O'Fallon, J and Allmer, C and (2003) Chromosome anomalies detected by interphase fluorescence in situ hybridization: Correlation with significant biological features of B-cell chronic lymphocytic leukaemia Br J Haematol, 121, pp. 287 - 295.
7. Dohner, H and Fischer, K and Bentz, M and Hansen, K and Benner, A and Cabot, G and (1995) p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias Blood, 85, pp. 1580 - 1589.
8. Dohner, H and Stilgenbauer, S and James, M and Benner, A and Lichter, P and (1997) 11q Deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis Blood, 89, pp. 2516 - 2522.
9. Dickinson, J and Smith, L and Sanger, W and Zhou, G and Townley, P and Lynch, J and (2005) Unique gene expression and clinical characteristics are associated with the 11q23 deletion in chronic lymphocytic leukemia Br J Haematol.
10. Ghia, P and Caligaris-Cappio, F. (2000) The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms Adv Cancer Res, 79, pp. 157 - 173.
11. Cuni, S and Perez-Aciego, P and Perez-Chacon, G and Vargas, J and Sanchez, A and Martin-Saavedra, F and (2004) A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells Leukemia, 18, pp. 1391 - 1400.
12. Pedersen, I and Kitada, S and Leoni, L and Zapata, J and Karras, J and Tsukada, N and (2002) Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1 Blood, 100, pp. 1795 - 1801.
13. Granziero, L and Ghia, P and Circosta, P and Gottardi, D and Strola, G and Geuna, M and (2001) Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia Blood, 97, pp. 2777 - 2783.
14. Panayiotidis, P and Jones, D and Ganeshaguru, K and Foroni, L and Hoffbrand, A. (1996) Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro Br J Haematol, 92, pp. 97 - 103.
15. Lopez-Giral, S and Quintana, N and Cabrerizo, M and Alfonso-Perez, M and Sala-Valdes, M and De Soria, V and (2004) Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination J Leukoc Biol, 76, pp. 462 - 471.
16. Till, K and Lin, K and Zuzel, M and Cawley, J. (2002) The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes Blood, 99, pp. 2977 - 2984.
17. Stratowa, C and Loffler, G and Lichter, P and Stilgenbauer, S and Haberl, P and Schweifer, N and (2001) CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking Int J Cancer, 91, pp. 474 - 480.
18. Angelopoulou, M and Kontopidou, F and Pangalis, G. (1999) Adhesion molecules in B-chronic lymphoproliferative disorders Semin Hematol, 36, pp. 178 - 197.
19. Tusher, V and Tibshirani, R and Chu, G. (2001) Significance analysis of microarrays applied to the ionizing radiation response Proc Natl Acad Sci USA, 98, pp. 5116 - 5121.
20. Shen, Y and Iqbal, J and Xiao, L and Lynch, R and Rosenwald, A and Staudt, L and (2004) Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs BMC Immunol, 5, pp. 20.
21. Alizadeh, A and Eisen, M and Davis, R and Ma, C and Lossos, I and Rosenwald, A and (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling Nature, 403, pp. 503 - 511.
22. Aalto, Y and El-Rifa, W and Vilpo, L and Ollila, J and Nagy, B and Vihinen, M and (2001) Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion Leukemia, 15, pp. 1721 - 1728.
23. Bosch, F and Villamor, N. (2003) Zap-70 Expression in chronic lymphocytic leukemia: A new parameter for an old disease Haematologica, 88, pp. 724 - 726.
24. Klein, U and Tu, Y and Stolovitzky, G and Mattioli, M and Cattoretti, G and Husson, H and (2001) Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells J Exp Med, 194, pp. 1625 - 1638.
25. Rosenwald, A and Alizadeh, A and Widhopf, G and Simon, R and Davis, R and Yu, X and (2001) Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia J Exp Med, 194, pp. 1639 - 1647.
26. Wiestner, A and Rosenwald, A and Barry, T and Staudt, L and Wright, G and Davis, R and Henrickson, S. (2003) ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile Blood, 101, pp. 4944 - 4951.
27. Krober, A and Seiler, T and Benner, A and Bullinger, L and Bruckle, E and Lichter, P and (2002) V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia Blood 100, pp. 1410 - 1416.
28. Chevallier, P and Penther, D and Avet-Loiseau, H and Robillard, N and Ifrah, N and Mahe, B and (2002) CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia Br J Haematol, 116, pp. 142 - 150.
29. Hamblin, T and Davis, Z and Gardiner, A and Oscier, D and Stevenson, F. (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia Blood, 94, pp. 1848 - 1854.
30. Ibrahim, S and Keating, M and Do, K and O'Brien, S and Huh, Y and Jilani, I and (2001) CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia Blood, 98, pp. 181 - 186.
31. Shiloh, Y. (2003) ATM and related protein kinases: Safeguarding genome integrity Nat Rev Cancer, 3, pp. 155 - 168.
32. Stankovi, T and Stewart, G and Byrd, P and Fegan, C and Moss, P and Taylor, A. (2002) ATM mutations in sporadic lymphoid tumours Leuk Lymphoma, 43, pp. 1563 - 1571.
33. Stankovic, T and Hubank, M and Cronin, D and Stewart, G and Fletcher, D and Bignell, C and (2003) Microarray analysis reveals that TP53 and ATM mutant B-CLLs share a defect in activation of pro-apoptotic responses following DNA damage but are distinguished by major differences in activation of pro-survival responses Blood, 103, pp. 291 - 300.
34. Stankovic, T and Stewart, G and Fegan, C and Biggs, P and Last, J and Byrd, P and (2002) Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage Blood, 99, pp. 300 - 309.
35. Starczynski, J and Simmons, W and Flavell, J and Byrd, P and Stewart, G and Kullar, H and (2003) Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias Am J Pathol, 163, pp. 423 - 432.
36. Schaffner, C and Stilgenbauer, S and Rappold, G and Dohner, H and Lichter, P. (1999) Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia Blood, 94, pp. 748 - 753.
37. Sembries, S and Pahl, H and Stilgenbauer, S and Dohner, H and Schriever, F. (1999) Reduced expression of adhesion molecules and cell signaling receptors by chronic lymphocytic leukemia cells with 11q deletion Blood 93, pp. 624 - 631.
38. Schadt, E and Monks, S and Drake, T and Lusis, A and Che, N and Colinayo, V and (2003) Genetics of gene expression surveyed in maize, mouse and man Nature, 422, pp. 297 - 302.
39. Kirst, M and Myburg, A and De Leon, J and Kirst, M and Scott, J and Sederoff, R. (2004) Coordinated genetic regulation of growth and lignin revealed by quantitative trait locus analysis of cDNA microarray data in an interspecific backcross of eucalyptus Plant Physiology, 135, pp. 2368 - 2378.
40. Bauvois, B and De Meester, I and Dumont, J and Rouillard, D and Zhao, H and Bosmans, E. (1999) Constitutive expression of CD26/ dipeptidylpeptidase IV on peripheral blood B lymphocytes of patients with B chronic lymphocytic leukaemia Br J Cancer, 79, pp. 1042 - 1048.
41. Aldinucci, D and Poletto, D and Lorenzon, D and Nanni, P and Degan, M and Olivo, K and (2004) CD26 expression correlates with a reduced sensitivity to 2′-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas Clin Cancer Res, 10, pp. 508 - 520.
42. Imai, T and Yoshida, T and Baba, M and Nishimura, M and Kakizaki, M and Yoshie, O. (1996) Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector J Biol Chem, 271, pp. 21514 - 21521.
43. Imai, T and Baba, M and Nishimura, M and Kakizaki, M and Takagi, S and Yoshie, O. (1997) The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 J Biol Chem, 272, pp. 15036 - 15042.
44. Chen, L and Wildhopf, G and Huynh, L and Rassenti, L and Rai, K and Weiss, A and (2002) Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia Blood, 100, pp. 4609 - 4619.
45. Crespo, M and Bosch, F and Villamor, N and Bellosillo, B and Colomer, D and Rozman, M and (2003) ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia N Engl J Med, 348, pp. 1764 - 1775.