Knock down of p53 levels in human keratinocytes increases susceptibility to type I and type II interferon-induced apoptosis mediated by a TRAIL dependent pathway

Journal of Dermatological Science

Volumn 41, Issue 1, 2006, Pages 31-41

  Chaturvedi, Vijaya ^a   Bodner, Barbara ^a   Qin, Jian Zhong ^a   Nickoloff, Brian J ^a,b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; Death receptor; HaCaT cells; Interferon; Keratinocytes; p53; siRNA; TRAIL

Indexed keywords

ALPHA1 INTERFERON; CASPASE 3; DEATH RECEPTOR; GAMMA INTERFERON; NEUTRALIZING ANTIBODY; PROTEIN P53; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CELL MUTANT; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; KERATINOCYTE; NICK END LABELING; PRIORITY JOURNAL; STAINING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TRANSFORMED; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; KERATINOCYTES; MEMBRANE GLYCOPROTEINS; RECEPTOR CROSS-TALK; RNA, SMALL INTERFERING; SKIN; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 30444457740     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2005.10.003     Document Type: Article

References (58)

1. B.J. Nickoloff, J.Z. Qin, V. Chaturvedi, P. Bacon, J. Panella, and M.F. Denning Life and death signaling pathways contributing to skin cancer J Invest Dermatol Symp Proc 7 2002 27 35
2. A.A. Dlugosz, and S.H. Yuspa Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C J Cell Biol 120 1993 217 225
3. R.L. Eckert, J.F. Crish, and N.A. Robinson The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation Physiol Rev 77 1997 397 424
4. J. Qin, V. Chaturvedi, B. Bonish, and B.J. Nickoloff Avoiding premature apoptosis of normal epidermal cells Nat Med 7 2001 385 386
5. J. Ye, A. Garg, C. Calhoun, K.R. Feingold, P.M. Elias, and R. Ghadially Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family Exp Dermatol 11 2002 209 216
6. Y. Teraki, and T. Shiohara Apoptosis and the skin Eur J Dermatol 9 1999 413 425
7. R.D. Sontheimer, E. Racila, and D.M. Racila C1q: its functions within the innate and adaptive immune responses and its role in lupus autoimmunity J Invest Dermatol 125 2005 14 23
8. S.I. Tobon-Arroyave, F.A. Villegas-Acosta, S.M. Ruiz-Restrepo, B. Vieco-Duran, M. Restrepo-Misas, and M.L. Londono-Lopez Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus Oral Dis 10 2004 173 178
9. A.C. Gilliam, D. Whitaker-Menezes, R. Korngold, and G.F. Murphy Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease J Invest Dermatol 107 1996 377 383
10. T. Banno, M. Adachi, L. Mukkamala, and M. Blumenberg Unique keratinocyte-specific effects of interferon-gamma that protect skin from viruses, identified using transcriptional profiling Antivir Ther 8 2003 541 554
11. R.G. Langley, N. Walsh, T. Nevill, L. Thomas, and G. Rowden Apoptosis is the mode of keratinocyte death in cutaneous graft-versus-host disease J Am Acad Dermatol 35 1996 187 190
12. F.O. Nestle, C. Conrad, A. Tun-Kyi, B. Homey, M. Gombert, and O. Boyman Plasmacytoid predendritic cells initiate psoriasis through interferon-{alpha} production J Exp Med 202 2005 135 143
13. M.M. Brysk, T. Bell, C. Hoida, S.K. Tyring, and S. Rajaraman Interferon-gamma modulates terminal differentiation and the expression of desquamin in cultured keratinocytes Exp Cell Res 197 1991 140 147
14. B.J. Nickoloff, T.Y. Basham, T.C. Merigan, and V.B. Morhenn Immunomodulatory and antiproliferative effect of recombinant alpha, beta, and gamma interferons on cultured human malignant squamous cell lines, SCL-1 and SW-1271 J Invest Dermatol 84 1985 487 490
15. A. Saitoh, A. Osada, Y. Kitajima, M. Furue, and K. Tamaki Interferon-gamma-induced HLA-DR, but not ICAM-1, expression of human keratinocytes is down-regulated by calmodulin antagonist J Dermatol 21 1994 716 719
16. S. Aiba, and H. Tagami HLA-DR antigen expression on the keratinocyte surface in dermatoses characterized by lymphocytic exocytosis (e.g. pityriasis rosea) Br J Dermatol 111 1984 285 294
17. J.C. Kim, D. Whitaker-Menezes, M. Deguchi, B.S. Adair, R. Korngold, and G.F. Murphy Novel expression of vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease Am J Pathol 161 2002 763 770
18. B.J. Nickoloff, R.S. Mitra, K. Lee, L.A. Turka, J. Green, and C. Thompson Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo Am J Pathol 142 1993 1029 1040
19. M.R. Quadros, F. Peruzzi, C. Kari, and U. Rodeck Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes Cancer Res 64 2004 3934 3939
20. S. Sano, K.S. Chan, S. Carbajal, J. Clifford, M. Peavey, and K. Kiguchi Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model Nat Med 11 2005 43 49
21. N.C. Reich, and A.J. Levine Specific interaction of the SV40 T antigen-cellular p53 protein complex with SV40 DNA Virology 117 1982 286 290
22. A. Takaoka, S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, and H. Kikuchi Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence Nature 424 2003 516 523
23. S. Pestka A dance between interferon-alpha/beta and p53 demonstrates collaborations in tumor suppression and antiviral activities Cancer Cell 4 2003 85 87
24. J. Vilcek Boosting p53 with interferon and viruses Nat Immunol 4 2003 825 826
25. D.E. Brash, J.A. Rudolph, J.A. Simon, A. Lin, G.J. McKenna, and H.P. Baden A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma Proc Natl Acad Sci USA 88 1991 10124 10128
26. A. Ziegler, A.S. Jonason, D.J. Leffell, J.A. Simon, H.W. Sharma, and J. Kimmelman Sunburn and p53 in the onset of skin cancer Nature 372 1994 773 776
27. K.H. Vousden p53: death star Cell 103 2000 691 694
28. V. Chaturvedi, L.A. Sitailo, J.Z. Qin, B. Bodner, M.F. Denning, and J. Curry Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis Oncogene 2005
29. C.C. Hofmeister, A. Quinn, K.R. Cooke, P. Stiff, B. Nickoloff, and J.L. Ferrara Graft-versus-host disease of the skin: life and death on the epidermal edge Biol Blood Marrow Transplant 10 2004 366 372
30. R. Ruckert, G. Lindner, S. Bulfone-Paus, and R. Paus High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivo Br J Dermatol 143 2000 1036 1039
31. A. Trautmann, M. Akdis, P. Schmid-Grendelmeier, R. Disch, E.B. Brocker, and K. Blaser Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis J Allergy Clin Immunol 108 2001 839 846
32. D. Whitaker-Menezes, S.C. Jones, T.M. Friedman, R. Korngold, and G.F. Murphy An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression Biol Blood Marrow Transplant 9 2003 559 570
33. V. Chaturvedi, J.Z. Qin, M.F. Denning, D. Choubey, M.O. Diaz, and B.J. Nickoloff Apoptosis in proliferating, senescent, and immortalized keratinocytes J Biol Chem 274 1999 23358 23367
34. P. Boukamp, R.T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N.E. Fusenig Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line J Cell Biol 106 1988 761 771
35. J.Z. Qin, P. Bacon, V. Chaturvedi, and B.J. Nickoloff Role of NF-kappaB activity in apoptotic response of keratinocytes mediated by interferon-gamma, tumor necrosis factor-alpha, and tumor-necrosis-factor-related apoptosis-inducing ligand J Invest Dermatol 117 2001 898 907
36. J.C. Gingrich, D.R. Davis, and Q. Nguyen Multiplex detection and quantitation of proteins on Western blots using fluorescent probes Biotechniques 29 2000 636 642
37. M.F. Denning, Y. Wang, S. Tibudan, S. Alkan, B.J. Nickoloff, and J.Z. Qin Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C Cell Death Differ 9 2002 40 52
38. X. Bai, F. Cerimele, M. Ushio-Fukai, M. Waqas, P.M. Campbell, and B. Govindarajan Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo J Biol Chem 278 2003 35501 35507
39. J.Z. Qin, P.E. Bacon, V. Chaturvedi, B. Bonish, and B.J. Nickoloff Pathways involved in proliferating, senescent and immortalized keratinocyte cell death mediated by two different TRAIL preparations Exp Dermatol 11 2002 573 583
40. J.Z. Qin, V. Chaturvedi, M.F. Denning, D. Choubey, M.O. Diaz, and B.J. Nickoloff Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes J Biol Chem 274 1999 37957 37964
41. A.J. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
42. J.L. Perfettini, R.T. Kroemer, and G. Kroemer Fatal liaisons of p53 with Bax and Bak Nat Cell Biol 6 2004 386 388
43. D.S. Hawkins, G.W. Demers, and D.A. Galloway Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents Cancer Res 56 1996 892 898
44. B.C. McKay, F. Chen, C.R. Perumalswami, F. Zhang, and M. Ljungman The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis Mol Biol Cell 11 2000 2543 2551
45. A.F. Wahl, K.L. Donaldson, C. Fairchild, F.Y. Lee, S.A. Foster, and G.W. Demers Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis Nat Med 2 1996 72 79
46. M. Leverkus, M. Neumann, T. Mengling, C.T. Rauch, E.B. Brocker, and P.H. Krammer Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes Cancer Res 60 2000 553 559
47. C. Dai, and S.B. Krantz Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells Blood 93 1999 3309 3316
48. S. Fulda, and K.M. Debatin IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway Oncogene 21 2002 2295 2308
49. H. Matsue, H. Kobayashi, T. Hosokawa, T. Akitaya, and A. Ohkawara Keratinocytes constitutively express the Fas antigen that mediates apoptosis in IFN gamma-treated cultured keratinocytes Arch Dermatol Res 287 1995 315 320
50. K. Sayama, S. Yonehara, Y. Watanabe, and Y. Miki Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes J Invest Dermatol 103 1994 330 334
51. K.J. Sung, E.M. Paik, K.A. Jang, H.S. Suh, and J.H. Choi Apoptosis is induced by anti-Fas antibody alone in cultured human keratinocytes J Dermatol 24 1997 427 434
52. A. Konur, U. Schulz, G. Eissner, R. Andreesen, and E. Holler Interferon (IFN)-gamma is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-gamma and tumour necrosis factor-alpha production Br J Dermatol 152 2005 1134 1142
53. C. Porta, R. Hadj-Slimane, M. Nejmeddine, M. Pampin, M.G. Tovey, and L. Espert Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively Oncogene 24 2005 605 615
54. L.C. Platanias Mechanisms of type-I- and type-II-interferon-mediated signalling Nat Rev Immunol 5 2005 375 386
55. F.O. Nestle, A. Farkas, and C. Conrad Dendritic-cell-based therapeutic vaccination against cancer Curr Opin Immunol 17 2005 163 169
56. F. McCormick Cancer therapy based on p53 Cancer J Sci Am 5 1999 139 144
57. V.A. Botchkarev, E.A. Komarova, F. Siebenhaar, N.V. Botchkareva, P.G. Komarov, and M. Maurer p53 is essential for chemotherapy-induced hair loss Cancer Res 60 2000 5002 5006
58. A.V. Gudkov, and E.A. Komarova Prospective therapeutic applications of p53 inhibitors Biochem Biophys Res Commun 331 2005 726 736