Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis

Journal of Allergy and Clinical Immunology

Volumn 108, Issue 5, 2001, Pages 839-846

  Trautmann, Axel ^a,b,c   Akdis, Mübeccel ^a   Schmid Grendelmeier, Peter ^a   Disch, Rainer ^a   Brocker, Eva B ^a   Blaser, Kurt ^a   Akdis, Cezmi A ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^b Clinic for Dermatology and Allergy   (Switzerland)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Allergic contact dermatitis; Apoptosis; Atopic dermatitis; Cyclosporine A; Dexamethasone; Intravenous immunoglobulin; Keratinocyte; Rapamycine; T cell; Tacrolimus fk506

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOMODULATING AGENT; RAPAMYCIN; TACROLIMUS; THEOPHYLLINE;

APOPTOSIS; ARTICLE; ATOPIC DERMATITIS; CONTACT DERMATITIS; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL; SKIN BIOPSY; T LYMPHOCYTE; TARGET CELL;

EID: 0035188843     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.118796     Document Type: Article

References (36)

1. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies
2. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
3. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen
4. Immune regulation in atopic dermatitis
5. Atopic dermatitis: New insights and opportunities for therapeutic intervention
6. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis
7. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis
8. The differential fate of cadherins during T cell-induced keratinocyte apoptosis leads to spongiosis in eczematous dermatitis
9. Therapeutic perspectives in atopic dermatitis
10. An overview of the efficiacy of topical corticosteroids in experimental human nickel contact dermatitis
11. Acute irritant dermatitis: Effect of short-term topical corticoid treatment
12. Comparison of two formulations of cyclosporin A treatment of severe atopic dermatitis. A double-blind, single-centre, cross-over pilot study
13. Treatment of severe atopic dermatitis in childhood with cyclosporin
14. Treatment of atopic dermatitis: Role of tacrolimus as a topical noncorticosteroidal therapy
15. Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis
16. The treatment of atopic dermatitis with adjunctive high-dose intravenous immunoglobulin: A report of three patients and review of the literature
17. Atopic dermatitis
18. Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells
19. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
20. Human keratinocytes maintain reversible anti-apoptotic defenses in vivo and in vitro
21. Apoptotic DNA fragmentation is detected by a semiquantitative ligation-mediated PCR of blunt DNA ends
22. Inflammatory skin diseases, T cells, and immune surveillance
23. Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema
24. Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-γ and Fas
25. Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial
26. Time-dependent inhibition of growth of human keratinocytes and fibroblasts by cyclosporin A: Effect on keratinocytes at therapeutic blood levels
27. FK506 in the treatment of inflammatory skin disease: Promises and perspectives
28. Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: Tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
29. Mechanisms of action of intravenous immune globulin in immune-mediated diseases
30. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immune globulin
31. Suppression of cytokine-dependent human T cell proliferation by intravenous immunoglobulin
32. Posttranscriptional regulation of T cell IL-2 production by human pooled immunoglobulin
33. Downregulation of interferon γ activated STAT1 by UV light
34. Theophylline and airway inflammation
35. Cytotoxicity is mandatory for CD8 T cell-mediated contact hypersensitivity
36. Disparate cytotoxic activity of nickel-specific CD8 and CD4 cell subsets against keratinocytes