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Volumn 126, Issue 2, 2004, Pages 165-172

DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity

Author keywords

Androgen receptor; DHEA; DHEA Sulfate; Endocrine and autonomic regulation; Gene expression; Mouse; Neuroendocrine regulation: other; Neurosteroids

Indexed keywords

ANDROGEN RECEPTOR; ENZYME INHIBITOR; HYDROXYSTEROID DEHYDROGENASE; PRASTERONE; PRASTERONE SULFATE; TRILOSTANE;

EID: 3042841152     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.05.001     Document Type: Article
Times cited : (38)

References (48)
  • 2
    • 1642553585 scopus 로고    scopus 로고
    • Neurosteroids: Beginning of the story
    • G. Biggio, & R.H. Purdy. San Diego: Academic Press
    • Baulieu E., Robel Pl., Schumacher M. Neurosteroids: beginning of the story. Biggio G., Purdy R.H. Neurosteroid and Brain Function. 2001;2-32 Academic Press, San Diego
    • (2001) Neurosteroid and Brain Function , pp. 2-32
    • Baulieu, E.1    Robel, Pl.2    Schumacher, M.3
  • 3
    • 0029992644 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids
    • Baulieu E.E., Robel P. Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids. J. Endocrinol. 150:1996;S221-S239
    • (1996) J. Endocrinol. , vol.150 , pp. 221-S239
    • Baulieu, E.E.1    Robel, P.2
  • 4
    • 0032960312 scopus 로고    scopus 로고
    • Immunocytochemical localization and biological activity of hydroxysteroid sulfotransferase in the frog brain
    • Beaujean D., Mensah-Nyagan A.G., Do-Rego J.L., Luu-The V., Pelletier G., Vaudry H. Immunocytochemical localization and biological activity of hydroxysteroid sulfotransferase in the frog brain. J. Neurochem. 72:1999;848-857
    • (1999) J. Neurochem. , vol.72 , pp. 848-857
    • Beaujean, D.1    Mensah-Nyagan, A.G.2    Do-Rego, J.L.3    Luu-The, V.4    Pelletier, G.5    Vaudry, H.6
  • 6
    • 0032516063 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development
    • Compagnone N.A., Mellon S.H. Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc. Natl. Acad. Sci. U. S. A. 95:1998;4678-4683
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 4678-4683
    • Compagnone, N.A.1    Mellon, S.H.2
  • 7
    • 0038699383 scopus 로고    scopus 로고
    • Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons
    • Cui H., Lin S.J., Belsham D.D. Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons. Mol. Cell. Endocrinol. 203:2003;13-23
    • (2003) Mol. Cell. Endocrinol. , vol.203 , pp. 13-23
    • Cui, H.1    Lin, S.J.2    Belsham, D.D.3
  • 8
    • 0032870870 scopus 로고    scopus 로고
    • Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally adminstered dehydroepiandrosterone sulfate but not pregnenolone sulfate
    • Flood J.F., Farr S.A., Johnson D.A., Li P.K., Morley J.E. Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally adminstered dehydroepiandrosterone sulfate but not pregnenolone sulfate. Psychoneuroendocrinology. 24:1999;799-811
    • (1999) Psychoneuroendocrinology , vol.24 , pp. 799-811
    • Flood, J.F.1    Farr, S.A.2    Johnson, D.A.3    Li, P.K.4    Morley, J.E.5
  • 9
    • 0037132499 scopus 로고    scopus 로고
    • In vivo activation of the constitutive androstane receptor beta (CARbeta) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA-S)
    • Fujita A.F.D., Tanaka T., Sakai R., Koyama A., Hanafusa T., Mitsuhashi T., Ohsawa N. In vivo activation of the constitutive androstane receptor beta (CARbeta) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA-S). FEBS Lett. 532:2002;373-378
    • (2002) FEBS Lett. , vol.532 , pp. 373-378
    • Fujita, A.F.D.1    Tanaka, T.2    Sakai, R.3    Koyama, A.4    Hanafusa, T.5    Mitsuhashi, T.6    Ohsawa, N.7
  • 10
    • 0038397605 scopus 로고    scopus 로고
    • Neurocognitive functioning in subjects with eating disorders: The influence of neuroactive steroids
    • Galderisi S., Mucci A., Monteleone P., Sorrentino D., Piegari G., Maj M. Neurocognitive functioning in subjects with eating disorders: the influence of neuroactive steroids. Biol. Psychiatry. 53:2003;921-927
    • (2003) Biol. Psychiatry , vol.53 , pp. 921-927
    • Galderisi, S.1    Mucci, A.2    Monteleone, P.3    Sorrentino, D.4    Piegari, G.5    Maj, M.6
  • 13
    • 0029798422 scopus 로고    scopus 로고
    • Cortisol, dehydroepiandrosterone (DHEA) sulfate in the cerebrospinal fluid of man; Relation to blood levels and the effects of age
    • Guazzo E.P., Kirkpatrick P.J., Goodyer I.M., Shiers H.M., Herbert J. Cortisol, dehydroepiandrosterone (DHEA) sulfate in the cerebrospinal fluid of man; relation to blood levels and the effects of age. J. Clin. Endocrinol. Metab. 81:1996;3951-3960
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3951-3960
    • Guazzo, E.P.1    Kirkpatrick, P.J.2    Goodyer, I.M.3    Shiers, H.M.4    Herbert, J.5
  • 14
    • 0035006622 scopus 로고    scopus 로고
    • Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons
    • Hammond J., Le Q., Goodyer C., Gelfand M., Trifiro M., LeBlanc A. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. Neurochem. Res. 77:2001;1319-1326
    • (2001) Neurochem. Res. , vol.77 , pp. 1319-1326
    • Hammond, J.1    Le, Q.2    Goodyer, C.3    Gelfand, M.4    Trifiro, M.5    Leblanc, A.6
  • 15
    • 0035162296 scopus 로고    scopus 로고
    • Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: Possible role of aromatization and 7-hydroxylation in neuroprotection
    • Jellinck P.H., Lee S.J., McEwen B.S. Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: possible role of aromatization and 7-hydroxylation in neuroprotection. J. Steroid Biochem. Mol. Biol. 78:2001;313-317
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.78 , pp. 313-317
    • Jellinck, P.H.1    Lee, S.J.2    McEwen, B.S.3
  • 16
    • 0036460078 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression
    • Karishma K.K., Herbert J. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression. Eur. J. Neurosci. 16:2002;445-453
    • (2002) Eur. J. Neurosci. , vol.16 , pp. 445-453
    • Karishma, K.K.1    Herbert, J.2
  • 17
    • 0037989013 scopus 로고    scopus 로고
    • Extragonadal synthesis of sex steroids: Intracrinology
    • Labrie F. Extragonadal synthesis of sex steroids: intracrinology. Ann. Endocrinol. 64:2003;95-107
    • (2003) Ann. Endocrinol. , vol.64 , pp. 95-107
    • Labrie, F.1
  • 18
    • 0037396439 scopus 로고    scopus 로고
    • Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
    • Labrie F., Luee-The V., Labrie C., Belanger A., Simard J., Lin S.X., Pelletier G. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocr. Rev. 24:2003;152-182
    • (2003) Endocr. Rev. , vol.24 , pp. 152-182
    • Labrie, F.1    Luee-The, V.2    Labrie, C.3    Belanger, A.4    Simard, J.5    Lin, S.X.6    Pelletier, G.7
  • 19
    • 0035230972 scopus 로고    scopus 로고
    • Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases
    • Lapchak P.A., Araujo D.M. Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases. Int. Rev. Neurobiol. 46:2001;379-397
    • (2001) Int. Rev. Neurobiol. , vol.46 , pp. 379-397
    • Lapchak, P.A.1    Araujo, D.M.2
  • 20
    • 0035847270 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia
    • Li H., Klein G.M., Sun P., Buchan A.M. Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia. Brain Res. 888:2001;263-266
    • (2001) Brain Res. , vol.888 , pp. 263-266
    • Li, H.1    Klein, G.M.2    Sun, P.3    Buchan, A.M.4
  • 21
    • 0031765501 scopus 로고    scopus 로고
    • Androgen receptor in mouse brain: Sex differences and similarities in autoregulation
    • Lu S., Mckenna S., Cologer-Cliford A., Nau G., Simon N. Androgen receptor in mouse brain: sex differences and similarities in autoregulation. Endocrinology. 139:1998;1594-1601
    • (1998) Endocrinology , vol.139 , pp. 1594-1601
    • Lu, S.1    McKenna, S.2    Cologer-Cliford, A.3    Nau, G.4    Simon, N.5
  • 22
    • 0142040175 scopus 로고    scopus 로고
    • Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity
    • Lu S., Mo Q., Hu S., Garippa C., Simon N.G. Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity. J. Neurobiol. 57:2003;163-171
    • (2003) J. Neurobiol. , vol.57 , pp. 163-171
    • Lu, S.1    Mo, Q.2    Hu, S.3    Garippa, C.4    Simon, N.G.5
  • 23
    • 0025091447 scopus 로고
    • The neurosteroid dehydroepiandrosterone sulfate is an allosteroid antagonist of the GABAA receptor
    • Majewska M.D., Demirgoren S., Spivak C.E., London E.D. The neurosteroid dehydroepiandrosterone sulfate is an allosteroid antagonist of the GABAA receptor. Brain Res. 526:1990;143-146
    • (1990) Brain Res. , vol.526 , pp. 143-146
    • Majewska, M.D.1    Demirgoren, S.2    Spivak, C.E.3    London, E.D.4
  • 24
    • 0026509649 scopus 로고
    • Neurosteroids: Endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance
    • Majewska M.D., Bell J.A., London E.D. Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 1992;379-395
    • (1992) Prog. Neurobiol. , pp. 379-395
    • Majewska, M.D.1    Bell, J.A.2    London, E.D.3
  • 25
  • 26
    • 0035053868 scopus 로고    scopus 로고
    • Unsulfated and sulfated neurosteroids differentially modulate the binding characteristics of various radioligands of GABA(A) receptors following chronic ethanol administration
    • Mehta A.K., Ticku M.K. Unsulfated and sulfated neurosteroids differentially modulate the binding characteristics of various radioligands of GABA(A) receptors following chronic ethanol administration. Neuropharmacology. 40:2001;668-675
    • (2001) Neuropharmacology , vol.40 , pp. 668-675
    • Mehta, A.K.1    Ticku, M.K.2
  • 27
    • 0035233563 scopus 로고    scopus 로고
    • Biosynthesis of neurosteroids and regulation of their synthesis
    • G. Biggio, & R.H. Purdy. San Diego, CA: Academic Press
    • Mellon S.H., Vaudry H. Biosynthesis of neurosteroids and regulation of their synthesis. Biggio G., Purdy R.H. Neurosteroids and Brain Function. 2001;33-78 Academic Press, San Diego, CA
    • (2001) Neurosteroids and Brain Function , pp. 33-78
    • Mellon, S.H.1    Vaudry, H.2
  • 28
    • 0035663971 scopus 로고    scopus 로고
    • Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids an amphibians
    • Mensah-Nygagan A.G., Beaujean D., Lu-The V., Pelletier G., Vaudry H. Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids an amphibians. Brain Res. Rev. 37:2001;13-24
    • (2001) Brain Res. Rev. , vol.37 , pp. 13-24
    • Mensah-Nygagan, A.G.1    Beaujean, D.2    Lu-The, V.3    Pelletier, G.4    Vaudry, H.5
  • 29
    • 0033614716 scopus 로고    scopus 로고
    • Sulfated and unsulfated steroids modulate gamma-aminobutyric acid a receptor function through distinct sites
    • Park-Cheung M., Malayev A., Purdy R.H., Gibbs T.T., Farb D.H. Sulfated and unsulfated steroids modulate gamma-aminobutyric acid A receptor function through distinct sites. Brain Res. 830:1999;72-87
    • (1999) Brain Res. , vol.830 , pp. 72-87
    • Park-Cheung, M.1    Malayev, A.2    Purdy, R.H.3    Gibbs, T.T.4    Farb, D.H.5
  • 30
    • 0037358433 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) and the aging brain: Flipping a coin in the "fountain of youth"
    • Racchi M., Balduzzi C., Corsini E. Dehydroepiandrosterone (DHEA) and the aging brain: flipping a coin in the "fountain of youth" CNS Drug Rev. 9:2003;21-40
    • (2003) CNS Drug Rev. , vol.9 , pp. 21-40
    • Racchi, M.1    Balduzzi, C.2    Corsini, E.3
  • 31
    • 0030908825 scopus 로고    scopus 로고
    • Hydroxysteroid sulfotransferase activity in the rat brain and liver as a function of age and sex
    • Rajkowski K.M., Robel P., Baulieu E.E. Hydroxysteroid sulfotransferase activity in the rat brain and liver as a function of age and sex. Steroids. 62:1997;427-436
    • (1997) Steroids , vol.62 , pp. 427-436
    • Rajkowski, K.M.1    Robel, P.2    Baulieu, E.E.3
  • 32
    • 0035225999 scopus 로고    scopus 로고
    • Neuroactive steroids in neuropshychopharmacology
    • Rupprecht R., Holsboer F. Neuroactive steroids in neuropshychopharmacology. Int. Rev. Neurobiol. 46:2001;461-477
    • (2001) Int. Rev. Neurobiol. , vol.46 , pp. 461-477
    • Rupprecht, R.1    Holsboer, F.2
  • 34
    • 0026565196 scopus 로고
    • Steroid hormones and steroid hormone binding globulins in cerebrospinal fluid: Studies in individuals with intact and with disturbed blood-cerebrospinal fluid barrier
    • Schwarz S., Pohl P. Steroid hormones and steroid hormone binding globulins in cerebrospinal fluid: studies in individuals with intact and with disturbed blood-cerebrospinal fluid barrier. Neuroendocrinology. 55:1992;174-182
    • (1992) Neuroendocrinology , vol.55 , pp. 174-182
    • Schwarz, S.1    Pohl, P.2
  • 35
    • 0033968952 scopus 로고    scopus 로고
    • The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice
    • Shi J., Schulze S., Lardy H.A. The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids. 65:2000;124-129
    • (2000) Steroids , vol.65 , pp. 124-129
    • Shi, J.1    Schulze, S.2    Lardy, H.A.3
  • 36
    • 0037387277 scopus 로고    scopus 로고
    • Conservation of hydroxysteroid sulfotransferease SULT2B1 gene structure in the mouse: Pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1
    • Shimizu C., Fuda H., Yanai H., Strott C.A. Conservation of hydroxysteroid sulfotransferease SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1. Endocrinology. 144:2003;1186-1193
    • (2003) Endocrinology , vol.144 , pp. 1186-1193
    • Shimizu, C.1    Fuda, H.2    Yanai, H.3    Strott, C.A.4
  • 37
    • 0038042835 scopus 로고    scopus 로고
    • Hormonal processes in the development and expression of aggressive behavior
    • D. Pfaff, A. Etgen, S. Fahrbach, & R. Rubin. San Diego: Academic Press
    • Simon N.G. Hormonal processes in the development and expression of aggressive behavior. Pfaff D., Etgen A., Fahrbach S., Rubin R. Hormones, the Brain, and Behavior. 2002;39-85 Academic Press, San Diego
    • (2002) Hormones, the Brain, and Behavior , pp. 39-85
    • Simon, N.G.1
  • 38
    • 0042816523 scopus 로고    scopus 로고
    • Dehydroepiandrosteorne modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms
    • Simoncini T., Mannella P., Fornari L., Varone G., Caruso A., Genazzani A.R. Dehydroepiandrosteorne modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology. 144:2003;3449-3455
    • (2003) Endocrinology , vol.144 , pp. 3449-3455
    • Simoncini, T.1    Mannella, P.2    Fornari, L.3    Varone, G.4    Caruso, A.5    Genazzani, A.R.6
  • 39
    • 0037312851 scopus 로고    scopus 로고
    • Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia
    • Strous R.D., Maayan R., Lapidus R., Stryjer R., Lustig M., Kotler J., Weizman A. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch. Gen. Psychiatry. 60:2003;133-141
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 133-141
    • Strous, R.D.1    Maayan, R.2    Lapidus, R.3    Stryjer, R.4    Lustig, M.5    Kotler, J.6    Weizman, A.7
  • 40
    • 0037198010 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) as a possible source of estrogen formation in bone cells: Correlation between bone mineral density and serum DHEA-sulfate concentration in postmenopausal women and the presence of aromatase to be enhanced by 1,25-dihydroxyvitamin D3 in human osteoblasts
    • Takayanagi R., Goto K., Suzuki S., Tanaka S., Shimoda S., Nawata H. Dehydroepiandrosterone (DHEA) as a possible source of estrogen formation in bone cells: correlation between bone mineral density and serum DHEA-sulfate concentration in postmenopausal women and the presence of aromatase to be enhanced by 1, 25-dihydroxyvitamin D3 in human osteoblasts. Mech. Ageing Dev. 123:2002;1107-1114
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1107-1114
    • Takayanagi, R.1    Goto, K.2    Suzuki, S.3    Tanaka, S.4    Shimoda, S.5    Nawata, H.6
  • 41
    • 0034789861 scopus 로고    scopus 로고
    • The andropause and memory loss: Is there a link between androgen decline and dementia in the aging male?
    • Tan R.S., Pu S.J. The andropause and memory loss: is there a link between androgen decline and dementia in the aging male? Asian J. Androl. 3:2001;169-174
    • (2001) Asian J. Androl. , vol.3 , pp. 169-174
    • Tan, R.S.1    Pu, S.J.2
  • 42
    • 0035666911 scopus 로고    scopus 로고
    • Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging
    • Vallee M., Mayo W., Moal M.L. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res. Rev. 37:2001;301-312
    • (2001) Brain Res. Rev. , vol.37 , pp. 301-312
    • Vallee, M.1    Mayo, W.2    Moal, M.L.3
  • 44
    • 0034993140 scopus 로고    scopus 로고
    • Salivary cortisol and DHEA: Association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation
    • van Niekerk J.K., Huppert F.A., Herbert J. Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation. Psychoneuroendocrinology. 26:2001;591-612
    • (2001) Psychoneuroendocrinology , vol.26 , pp. 591-612
    • Van Niekerk, J.K.1    Huppert, F.A.2    Herbert, J.3
  • 46
    • 0037988962 scopus 로고    scopus 로고
    • Cognitive functions and sex steroids
    • Wolf O.T. Cognitive functions and sex steroids. Ann. Endocrinol. 64:2003;158-161
    • (2003) Ann. Endocrinol. , vol.64 , pp. 158-161
    • Wolf, O.T.1
  • 48
    • 0027951243 scopus 로고
    • Neurosteroids: Pharmacological effects of a 3β-hydroxysteroid dehydrogenaise inhibitor
    • Young J., Corpechot C., Perche F., Haug M., Baulieu E.E., Robel P. Neurosteroids: pharmacological effects of a 3β-hydroxysteroid dehydrogenaise inhibitor. Endocrine. 2:1994;505-509
    • (1994) Endocrine , vol.2 , pp. 505-509
    • Young, J.1    Corpechot, C.2    Perche, F.3    Haug, M.4    Baulieu, E.E.5    Robel, P.6


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