Dehydroepiandrosterone (DHEA) as a possible source for estrogen formation in bone cells: Correlation between bone mineral density and serum DHEA-sulfate concentration in postmenopausal women, and the presence of aromatase to be enhanced by 1,25-dihydroxyvitamin D3 in human osteoblasts

Mechanisms of Ageing and Development

Volumn 123, Issue 8, 2002, Pages 1107-1114

  Takayanagi, Ryoichi ^a   Goto, Kiminobu ^a   Suzuki, Shizu ^a   Tanaka, Seiichi ^a   Shimoda, Seiko ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

1,25 Dihydroxyvitamin D3; Aromatase; Dehydroepiandrosterone; Estrogen; Osteoblast; Osteoporosis

Indexed keywords

AROMATASE; CALCITRIOL; CYTOCHROME P450; GLUCOCORTICOID; PRASTERONE; PRASTERONE SULFATE; VITAMIN D;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CONTROLLED STUDY; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL CULTURE; MENOPAUSE; OSTEOBLAST; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

24,25-DIHYDROXYVITAMIN D 3; AGED; AGED, 80 AND OVER; AROMATASE; BONE DENSITY; CALCITRIOL; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DEXAMETHASONE; ESTRADIOL; ESTROGENS; FEMALE; FEMUR; HUMANS; MIDDLE AGED; OSTEOBLASTS; POSTMENOPAUSE; PROMOTER REGIONS (GENETICS); TRETINOIN;

EID: 0037198010     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00394-3     Document Type: Article

References (11)

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2. Characterization of human bone cells in culture
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4. Steroid sulfatase activity in osteoblast cells
5. Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis
6. Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue
7. Establishment and characterization of PTHrP-producing human pancreatic cancer cell line
8. The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women
9. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man
10. Aromatase activity in human osteoblast-like osteosarcoma cell
11. 1,25-dihydroxyvitamin D3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts