Learning about cardiac calcium signaling from genetic engineering

Annals of the New York Academy of Sciences

Volumn 1015, Issue , 2004, Pages 1-15

  Morad, Martin ^a   Chau, M Y ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Ca 2+ sparks; Ca2+ signaling; CICR mechanism; Genetic insight; RyRs

Indexed keywords

1,4 DIHYDROPYRIDINE RECEPTOR; CALCIUM CHANNEL; CALCIUM SENSING RECEPTOR; CALMODULIN BINDING PROTEIN;

CALCIUM CURRENT; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CYTOPLASM; GENE DELETION; GENE EXPRESSION; GENETIC ENGINEERING; HEART ARRHYTHMIA; HEART ATRIUM; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE WALL; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN DEFECT; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TRANSVERSE TUBULAR SYSTEM;

ANIMALIA; MUS MUSCULUS;

EID: 3042831453     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1302.001     Document Type: Conference Paper

References (43)

1. + release sites in rat cardiac myocytes. Proc. Natl. Acad. Sci. USA 95: 10984-10989.
2. CHENG, H., W.J. LEDERER & M.B. CANNELL. 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262: 740-744.
3. FABIATO, A., & F. FABIATO. 1975. Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells. J. Physiol. 249: 469-495.
4. 2+ channels and ryanodine receptors in cardiac myocytes. Proc. Natl. Acad. Sci. USA 92: 121-125.
5. 2+ channels and ryanodine receptors in rat ventricular myocytes. J. Gen. Physiol. 108: 435-454.
6. MORAD, M., & Y. GOLDMAN. 1973. Excitation-contraction coupling in heart muscle: membrane control of development of tension. Prog. Biophys. Mol. Biol. 27: 257-313.
7. 2+ transients and contraction. J. Physiol. 432: 283-312.
8. NABAUER, M., G. CALLEWAERT, L. CLEEMANN & M. MORAD. 1989. Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes. Science 244: 800-803.
9. NIGGLI, E., & W.J. LEDERER. 1990. Voltage-independent calcium release in heart muscle. Science 250: 565-568.
10. + in single ventricular myocytes. Am. J. Physiol. 258: C189-193.
11. 2+ in voltage-clamped rat heart cells: visualization with confocal microscopy. J. Physiol. 480: 21-29.
12. 2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ. Res. 78: 166-171.
13. + cross signaling between DHP and ryanodine receptors in rat ventricular myocytes. Am. J. Physiol. 276: H1178-1189.
14. 2+ channel inactivation. Segment exchange analysis of the carboxyl-terminal cytoplasmic motif encoded by exons 40-42 of the human alpha1C subunit gene. J. Biol. Chem. 273: 957-963.
15. 2+ signaling in rat atrial myocytes: possible role of {alpha} 1C carboxyl terminal. J. Physiol. 552: 437-447.
16. 2+ exchanger. J. Gen. Physiol. 109: 717-729.
17. 2+-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. J. Mol. Cell. Cardiol. 34: 389-400.
18. 2+ exchanger. J. Pharmacol. Exp. Ther. 294: 648-657.
19. 2+ exchanger. J. Physiol. 512: 651-667.
20. +]i transients in murine ventricular myocytes. Circ. Res. 82: 657-665.
21. +-channel agonist without sarcoplasmic reticulum protein changes in transgenic mice. Biochem. Biophys. Res. Commun. 249: 786-790.
22. 2+ channel in transgenic mice. Loss of isoproterenol-induced contraction. J. Biol. Chem. 274: 21503-21506.
23. 2+-dependent transgenic model of cardiac hypertrophy: a role for protein kinase Calpha. Circulation 103: 140-147.
24. 2+ channel. Circ. Res. 90: 174-181.
25. HOIT, B.D., D.A. TRAMUTA, V.J. KADAMBI, et al. 1999. Influence of transgenic overexpression of phospholamban on postextrasystolic potentiation. J. Mol. Cell. Cardiol. 31: 2007-2015.
26. KADAMBI, V.J., K.L. KOSS, I.L. GRUPP & E.G. KRANIAS. 1998. Phospholamban modulates murine atrial contractile parameters and responses to beta-adrenergic agonists. J. Mol. Cell. Cardiol. 30: 1275-1284.
27. KADAMBI, V.J., S. PONNIAH, J.M. HARRER, et al. 1996. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J. Clin. Invest. 97: 533-539.
28. 2+ channel currents in mouse atrial myocytes. J. Mol. Cell. Cardiol. 30: 317-325.
29. LUO, W., I.L. GRUPP, J. HARRER, et al. 1994. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ. Res. 75: 401-409.
30. CHU, G., W. LUO, J.P. SLACK, et al. 1996. Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts. Circ. Res. 79: 1064-1076.
31. LI, L., G. CHU, E.G. KRANIA & D.M. BERS. 1998. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. Am. J. Physiol. 274: H1335-1347.
32. 2+. Am. J. Physiol. 271: C391-397.
33. SANTANA, LF., E.G. KRANIAS & W.J. LEDERER. 1997. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. J. Physiol. 503: 21-29.
34. SLACK, J.P., I.L. GRUPP, R. DASH, et al. 2001. The enhanced contractility of the phospholamban-deficient mouse heart persists with aging. J. Mol. Cell. Cardiol. 33: 1031-1040.
35. 2+ channels in mouse ventricular myocytes. Am. J. Physiol. 272: H606-612.
36. 2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ. Res. 83: 1205-1214.
37. 2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J. Clin. Invest. 100: 380-389.
38. 2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J. Clin. Invest. 101: 1385-1393.
39. KNOLLMANN, B.C., B.E. KNOLLMANN-RITSCHEL, N.J. WEISSMAN, et al. 2000. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J. Physiol. 525: 483-498.
40. 2+ release in calsequestrin-overexpressing mouse cardiomyocytes. J. Physiol. 524: 399-414.
41. SATO, Y., H. KIRIAZIS, A. YATANI, et al. 2001. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. J. Biol. Chem. 276: 9392-9399.
42. SATO, Y., D.G. FERGUSON, H. SAKO, et al. 1998. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. J. Biol. Chem. 273: 28470-28477.
43. SCHMIDT, A.G., V.J. KADAMBI, N. BALL, et al. 2000. Cardiac-specific overexpression of calsequestrin results in left ventricular hypertrophy, depressed force-frequency relation and pulsus alternans in vivo. J. Mol. Cell. Cardiol. 32: 1735-1744.