Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 2090-2099

  Biondo, M ^a   Nasa, Z ^a   Marshall, A ^a   Toh, B H ^a   Alderuccio, F ^a  

^a MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GASTRITIS; HYPERTROPHY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH MUCOSA; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0035253497     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.2090     Document Type: Article

References (62)

1. Pernicious anaemia
2. Autoimmune gastritis and pernicious anemia
3. Genetic susceptibility to post-thymectomy autoimmune diseases in mice
4. Organ-specific autoimmunity induced by lymphopenia
5. +ATPase induces a reversible autoimmune gastritis
6. Spontaneous autoimmune gastritis in C3H/He mice: A new mouse model for gastric autoimmunity
7. Autoimmune gastritis results in disruption of gastric epithelial cell development
8. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset
9. Tolerance mechanisms in experimental ovarian and gastric autoimmune diseases
10. + T cells, are required for the development of experimental autoimmune gastritis
11. Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis
12. Expression of the gastric H/K ATPase α-subunit in the thymus may explain the dominant role of the β-subunit in the pathogenesis of autoimmune gastritis
13. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus
14. Identification of a gastritogenic epitope of the H/K ATPase β-subunit
15. Post-thymectomy auoimmune gastritis: Fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells
16. Structure of the TCR expressed on a gastritogenic T cell clone, II-6, and frequent appearance of similar clonotypes in mice bearing autoimmune gastritis
17. Immunological self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
18. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
19. + naturally anergic and supressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
20. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunological self-tolerance
21. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
22. T cell-mediated maintenance of natural self-tolerance: Its breakdown as a possible cause of various autoimmune diseases
23. The granulocyte-macrophage colony-stimulating factors
24. A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine
25. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
26. A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor
27. Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
28. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice
29. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
30. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice
31. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice
32. Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
33. Immunologic and clinical studies in murine experimental autoimmune gastritis induced by neonatal thymectomy
34. Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression
35. Ionizing radiation and autoimmunity: Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells
36. The mouse gastric H,K-ATPase β subunit
37. Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages
38. +-ATPase complex by tomato-lectin affinity chromotography
39. The parietal cell autoantibodies recognised in neonatal thymectomy induced murine gastritis are the α and β subunits of the gastric proton pump
40. A novel method for isolating mononuclear cell from the stomachs of mice with experimental autoimmune gastritis
41. Molecular physiology of granulocyte-macrophage colony-stimulating factor
42. Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy: Immunopathology
43. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
44. Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy: Autoantibodies
45. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
46. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
47. Natural adjuvants: Endogenous activators of dendritic cells
48. In vivo administration of GMCSF promotes the clearance of apoptotic cells: Effects on monocytes and polymorphonuclear leukocytes
49. Local expression of TNFα in neonatal NOD mice promotes diabetes by-enhancing presentation of islet antigens
50. DNA cancer vaccines: A gene gun approach
51. Therapy of established tumour with a hybrid cellular vaccine generated by using granulocyte-macrophage colony-stimulating factor genetically modified dendritic cells
52. Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including ' immature dendritic cells into injected muscles
53. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue
54. Autoimmune diabetes as consequence of locally produced interleukin-2
55. Transgenic TNF-α production in pancreatic islets leads to insulitis, not diabetes: Distinct patterns of inflammation in TNF-α and TNF-β transgenic mice
56. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ
57. Immunopathology of autoimmune gastritis: Lessons from mouse models
58. Diabetes induced by coxsackie virus: Initiation by bystander damage and not molecular mimicry
59. An innate sense of danger
60. Tolerance, danger, and the extended family
61. The causative H/K ATPase antigen in the pathogenesis of autoimmune gastritis