Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase

Antioxidants and Redox Signaling

Volumn 6, Issue 4, 2004, Pages 721-728

  Franke, Kai ^a,b   Curth, Katja ^b   Lenart, Jacek ^b   Knochenhauer, Doreen ^b   Kietzmann, Thomas ^b  

^a IBA GmbH   (Germany)

^b Inst fur Biochem/Molek Zellbiol   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DOXYCYCLINE; DRINKING WATER; GLUTATHIONE PEROXIDASE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; REACTIVE OXYGEN METABOLITE; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GLUTATHIONE PEROXIDASE GENE; LIVER CELL; LIVER FIBROSIS; MOUSE; NONHUMAN; PLASMINOGEN ACTIVATOR INHIBITOR 1 GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SUPEROXIDE DISMUTASE GENE; THROMBOSIS; TRANSACTIVATION; TRANSGENIC MOUSE;

ANIMALS; FIBROSIS; GENE EXPRESSION REGULATION; GLUTATHIONE PEROXIDASE; HEPATOCYTES; MICE; MICE, TRANSGENIC; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN SYNTHESIS INHIBITORS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TETRACYCLINE;

ANIMALIA; MUS MUSCULUS; TRIXIS;

EID: 3042785849     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/1523086041361613     Document Type: Article

References (57)

1. Alcolado R, Arthur MJ, and Iredale JP. Pathogenesis of liver fibrosis. Clin Sci (Lond) 92: 103-112, 1997.
2. Andreasen PA, Egelund R, and Petersen HH. The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57: 25-40, 2000.
3. Baron U and Bujard H. Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol 327: 401-421, 2000.
4. Baron U, Freundlieb S, Gossen M, and Bujard H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. NucleicAcids Res 23: 3605-3606, 1995.
5. Bartels H, Linnemann H, and Jungermann K. Predominant localization of phosphoenolpyruvate carboxykinase mRNA in the periportal zone of rat liver parenchyma demonstrated by in situ hybridization. FEBS Lett 248: 188-194, 1989.
6. Bedossa P and Paradis V. Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis. J Hepatol 22: 37-42, 1995.
7. Bisgaard HC, Santoni RE, Nagy P, and Thorgeirsson SS. Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells. Lab Invest 78: 237-246, 1998.
8. Bissell DM. Hepatic fibrosis as wound repair: a progress report. J Gastroenterol 33: 295-302, 1998.
9. Busso N, Nicodeme E, Chesne C, Guillouzo A, Belin D, and Hyafil F. Urokinase and type I plasminogen activator inhibitor production by normal human hepatocytes: modulation by inflammatory agents. Hepatology 20: 186-190, 1994.
10. Casini A, Ceni E, Salzano R, Biondi P, Parola M, Galli A, Foschi M, Caligiuri A, Pinzani M, and Surrenti C. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. Hepatology 25: 361-367, 1997.
11. Ceriello A, Curcio F, dello Russo P, Pegoraro I, Stel G, Amstad P, and Cerutti P. The defence against free radicals protects endothelial cells from hyperglycaemia-induced plasminogen activator inhibitor 1 over-production. Blood Coagul Fibrinolysis 6: 133-137, 1995.
12. Chance B, Sies H, and Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527-605, 1979.
13. Cheng JJ, Chao YJ, Wung BS, and Wang DL. Cyclic strain-induced plasminogen activator inhibitor-1 (PAI-1) release from endothelial cells involves reactive oxygen species. Biochem Biophys Res Commun 225: 100-105, 1996.
14. Dennler S, Itoh S, Vivien D, Ten-Dijke P, Huet S, and Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17: 3091-3100, 1998.
15. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2002.
16. Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, and Brownlee M. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci U S A 97: 12222-12226, 2000.
17. Eberhardt W, Beck KF, and Pfeilschifter J. Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells. Kidney Int 61: 20-30, 2002.
18. Eitzman DT, Westrick RJ, Xu Z, Tyson J, and Ginsburg D. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood 96: 4212-4215, 2000.
19. Erickson LA, Hekman CM, and Loskutoff DJ. The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related. Proc Natl Acad Sci USA 82: 8710-8714, 1985.
20. Fearns C and Loskutoff DJ. Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha. Am J Pathol 150: 579-590, 1997.
21. Gebhardt R. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med 68: 289-296, 2002.
22. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, and Busse R. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circ Res 89: 47-54, 2001.
23. Gorlach A, Kietzmann T, and Hess J. Redox signaling through NADPH oxidases: involvement in vascular proliferation and coagulation. Ann N Y Acad Sci 973: 505-507, 2002.
24. Gorlach A, Berchner-Pfannschmidt U, Wotzlaw C, Cool RH, Fandrey J, Acker H, Jungermann K, and Kietzmann T. Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1. Thromb Haemost 89: 927-935, 2003.
25. Gossen M and Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89: 5547-5551, 1992.
26. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, and Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 268: 1766-1769, 1995.
27. Gressner AM and Bachem MG. Cellular communications and cell-matrix interactions in the pathogenesis of fibroproliferative diseases: liver fibrosis as a paradigm. Ann Biol Clin (Paris) 52: 205-226, 1994.
28. Heaton JH, Nebes VL, O'Dell LG, Morris SM Jr, and Gelehrter TD. Glucocorticoid and cyclic nucleotide regulation of plasminogen activator and plasminogen activator-inhibitor gene expression in primary cultures of rat hepatocytes. Mol Endocrinol 3: 185-192, 1989.
29. Hogan B, Costantini F, and Beddington R. Manipulating the Mouse Embryo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2002.
30. Huber K. Plasminogen activator inhibitor type-1 (part one): basic mechanisms, regulation, and role for thromboembolic disease. J Thromb Thrombolysis 11: 183-193, 2001.
31. Immenschuh S, Hinke V, Ohlmann A, Gifhorn-Katz S, Katz N, Jungermann K, and Kietzmann T. Transcriptional activation of the haem oxygenase-1 gene by cGMP via a cAMP response element/activator protein-1 element in primary cultures of rat hepatocytes. Biochem J 334: 141-146, 1998.
32. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, and Arthur MJ. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102: 538-549, 1998.
33. Jiang Z, Seo JY, Ha H, Lee EA, Kim YS, Han DC, Uh ST, Park CS, and Lee HB. Reactive oxygen species mediate TGF-beta1-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells. Biochem Biophys Res Commun 309:961-966, 2003.
34. 2. FEBS Lett 388: 228-232, 1996.
35. Kietzmann T, Roth U, and Jungermann K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia inducible factor-1 in rat hepatocytes. Blood 94: 4177-4185, 1999.
36. Kietzmann T, Jungermann K, and Gorlach A. Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases in HepG2 cells. Thromb Haemost 89: 666-674, 2003.
37. Kruithof EK, Vassalli JD, Schleuning WD, Mattaliano RJ, and Bachmann F. Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937. J Biol Chem 261: 11207-11213, 1986.
38. Lijnen HR and Collen D. Mechanisms of plasminogen activation by mammalian plasminogen activators. Enzyme 40: 90-96, 1988.
39. Loskutoff DJ and Quigley JP. PAI-1, fibrosis, and the elusive provisional fibrin matrix. J Clin Invest 106: 1441-1443, 2000.
40. Motojima M, Hosokawa A, Yamato H, Muraki T, and Yoshioka T. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. Kidney Int 63: 1671-1680, 2003.
41. Okada H, Woodcock MJ, Mitchell J, Sakamoto T, Marutsuka K, Sobel BE, and Fujii S. Induction of plasminogen activator inhibitor type 1 and type 1 collagen expression in rat cardiac microvascular endothelial cells by interleukin-1 and its dependence on oxygen-centered free radicals. Circulation 97: 2175-2182, 1998.
42. Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 21: 49-98, 2000.
43. Reilly CF and McFall RC. Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells. J Biol Chem 266: 9419-9427, 1991.
44. Sakamoto T, Woodcock-Mitchell J, Marutsuka K, Mitchell JJ, Sobel BE, and Fujii S. TNF-alpha and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes. Am J Physiol 276: C1391-C1397, 1999.
45. Schneiderman J, Sawdey M, Craig H, Thinnes T, Bordin G, and Loskutoff DJ. Type 1 plasminogen activator inhibitor gene expression following partial hepatectomy. Am J Pathol 143: 753-762, 1993.
46. Schonig K and Bujard H. Generating conditional mouse mutants via tetracycline-controlled gene expression. Methods Mol Biol 209: 69-104, 2003.
47. Schuppan D, Koda M, Bauer M, and Hahn EG. Fibrosis of liver, pancreas and intestine: common mechanisms and clear targets? Acta Gastroenterol Belg 63: 366-370, 2000.
48. Seki T, Imai H, Uno S, Ariga T, and Gelehrter TD. Production of tissue-type plasminogen activator (t-PA) and type-1 plasminogen activator inhibitor (PAI-1) in mildly cirrhotic rat liver. Thromb Haemost 75: 801-807, 1996.
49. Shimizu M, Hara A, Okuno M, Matsuno H, Okada K, Ueshima S, Matsuo O, Niwa M, Akita K, Yamada Y, Yoshimi N, Uematsu T, Kojima S, Friedman SL, Moriwaki H, and Mori H. Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: Impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis. Hepatology 33: 569-576, 2001.
50. Swiatkowska M, Szemraj J, Al Nedawi KN, and Pawlowska Z. Reactive oxygen species upregulate expression of PAI-1 in endothelial cells. Cell Mol Biol Lett 7: 1065-1071, 2002.
51. Toyokuni S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49: 91-102, 1999.
52. Trotti R, Rondanelli M, Anesi A, Gabanti E, Brustia R, and Minoli L. Increased erythrocyte glutathione peroxidase activity and serum tumor necrosis factor-alpha in HIV-infected patients: relationship to on-going prothrombotic state. J Hematother Stem Cell Res 11: 369-375, 2002.
53. Uno S, Nakamura M, Seki T, and Ariga T. Induction of tissue-type plasminogen activator (tPA) and type-1 plasminogen activator inhibitor (PAI-1) as early growth responses in rat hepatocytes in primary culture. Biochem Biophys Res Commun 239: 123-128, 1997.
54. Xu D, Neville R, and Finkel T. Homocysteine accelerates endothelial cell senescence. FEBS Lett 470: 20-24, 2000.
55. Yu L, Hebert MC, and Zhang YE. TGF-beta receptor-activated p38 MAP kinase mediates Smad-indcpendent TGF-beta responses. EMBO J 21: 3749-3759, 2002.
56. Zeheb R, Rafferty UM, Rodriguez MA, Andreasen P, and Gelehrter TD. Immunoaffinity purification of HTC rat hepatoma cell plasminogen activator-inhibitor-1. Thromb Haemost 58: 1017-1023, 1987.
57. Zhao W, Spitz DR, Oberley LW, and Robbins ME. Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. Cancer Res 61: 5537-5543, 2001.