Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines

Kidney International

Volumn 66, Issue 1, 2004, Pages 91-101

  Schiwek, Daniel ^b   Endlich, Nicole ^b   Holzman, Lawrence ^b   Holthöfer, Harry ^b   Kriz, Wilhelm ^b   Endlich, Karlhans ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE

Author keywords

Cell cell contact; Nephrin; Podocytes

Indexed keywords

CADHERIN; CD2 ANTIGEN; CORTACTIN; F ACTIN; NEPHRIN; PODOCALYXIN; PODOCIN; PODOPLANIN; PROTEIN; PROTEIN LMX 1B; PROTEIN NEHP1; PROTEIN ZO1; SYNAPTOPODIN; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CLONE; CELL CONTACT; CELL JUNCTION; CONTROLLED STUDY; DILUTION; GLOMERULUS; IMMOBILIZED CELL; IMMUNOFLUORESCENCE; ISOLATED KIDNEY; MOUSE; NEPHROBLASTOMA; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE SENSITIVITY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 3042766207     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00711.x     Document Type: Article

References (45)

1. ENDLICH K, KRIZ W, WITZGALL R: Update in podocyte biology. Curr Opin Nephrol Hypertens 10:331-340, 2001
2. KERJASCHKI D: Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 108:1583-1587, 2001
3. PAVENSTÄDT H, KRIZ W, KRETZLER M: Cell biology of the glomerular podocyte. Physiol Rev 83:253-307, 2003
4. HOLZMAN LB, ST. JOHN PL, KOVARI IA, et al: Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56:1481-1491, 1999
5. KESTILA M, LENKKERI U, MANNIKKO M, et al: Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1:575-582, 1998
6. INOUE T, YAOITA E, KURIHARA H, et al: FAT is a component of glomerular slit diaphragms. Kidney Int 59:1003-1012, 2001
7. REISER J, KRIZ W, KRETZLER M, MUNDEL P: The glomerular slit diaphragm is a modified adherens junction. J Am Soc Nephrol 11:1-8, 2000
8. BOUTE N, GRIBOUVAL O, ROSELLI S, et al: NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24:349-354, 2000
9. SHIH NY, LI J, KARPITSKII V, et al: Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science 286:312-315, 1999
10. SCHNABEL E, ANDERSON JM, FARQUHAR MG: The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol 111:1255-1263, 1990
11. BARLETTA GM, KOVARI IA, VERMA RK, et al: Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. J Biol Chem 278:19266-19271, 2003
12. PUTAALA H, SOININEN R, KILPELAINEN P, et al: The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10:1-8, 2001
13. RANTANEN M, PALMEN T, PATARI A, et al: Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions. J Am Soc Nephrol 13:1586-1594, 2002
14. MUNDEL P, HEID HW, MUNDEL TM, et al: Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 139:193-204, 1997
15. MUNDEL P, REISER J, BORJA AZ, et al: Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236:248-258, 1997
16. SHIH NY, LI J, COTRAN R, et al: CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol 159:2303-2308, 2001
17. YAN K, KHOSHNOODI J, RUOTSALAINEN V, TRYGGVASON K: N-linked glycosylation is critical for the plasma membrane localization of nephrin. J Am Soc Nephrol 13:1385-1389, 2002
18. DOUBLIER S, ROUTSALAINEN V, SALVIDIO G, et al: Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 158:1723-1731, 2001
19. SALEEM MA, O'HARE MJ, REISER J, et al: A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13:630-638, 2002
20. SALEEM MA, NI L, WITHERDEN I, et al: Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol 161:1459-1466, 2002
21. b-tsA58 transgenic mouse. Proc Natl Acad Sci USA 88:5096-5100, 1991
22. ENDLICH N, KRESS KR, REISER J, et al: Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 12:413-422, 2001
23. MUNDLOS S, PELLETIER J, DARVEAU A, et al: Nuclear localiziation of the protein encoded by the Wilm's tumor gene WT1 in embryonic and adult tissues. Development 119:1329-1341, 1993
24. YAOITA E, KURIHARA H, SAKAI T, et al: Phenotypic modulation of parietal epithelial cells of Bowman's capsule in culture. Cell Tissue Res 304:339-349, 2001
25. MOELLER MJ, SANDEN SK, SOOFI A, et al: Two gene fragments that direct podocyte-specific expression in transgenic mice. J Am Soc Nephrol 13:1561-1567, 2002
26. AHOLA H, WANG SX, LUIMULA P, et al: Cloning and expression of the rat nephrin homolog. Am J Pathol 155:907-913, 1999
27. CHEN H, LUN Y, OVCHINNIKOV D, et al: Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet 19:51-55, 1998
28. KURIHARA H, ANDERSON JM, FARQUHAR MG: Diversity among tight junctions in rat kidney: Glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1. Proc Natl Acad Sci USA 89:7075-7079, 1992
29. BREITENEDER-GELEFF S, MATSUI K, SOLEIMAN A, et al: Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am J Pathol 151:1141-1152, 1997
30. KERJASCHKI D, SHARKEY DJ, FARQUHAR MG: Identification and characterization of podocalyxin - The major sialoprotein of the renal glomerular epithelial cell. J Cell Biol 98:1591-1596, 1984
31. RODEWALD R, KARNOVSKY MJ: Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 60:423-433, 1972
32. MUNDEL P, KRIZ W: Structure and function of podocytes: an update. Anat Embryol (Berlin) 192:385-397, 1995
33. WELSCH T, ENDLICH N, KRIZ W, ENDLICH K: CD2AP and p130Cas localize to different F-actin structures in podocytes. Am J Physiol Renal Physiol 281:F769-F777, 2001
34. TRYGGVASON K, WARTIOVAARA J: Molecular basis of glomerular permselectivity. Curr Opin Nephrol Hypertens 10:543-549, 2001
35. DUSTIN ML, OLSZOWY MW, HOLDORF AD, et al: A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 94:667-677, 1998
36. PALMEN T, LEHTONEN S, ORA A, et al: Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line. J Am Soc Nephrol 13:1766-1772, 2002
37. URUNO T, LIU J, ZHANG P, et al: Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol 3:259-266, 2001
38. SCHAFER DA, WELCH MD, MACHESKY LM, et al: Visualization and molecular analysis of actin assembly in living cells. J Cell Biol 143:1919-1930, 1998
39. KAKSONEN M, PENG HB, RAUVALA H: Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles. J Cell Sci 113:4421-4426, 2000
40. SCHAFER DA, D'SOUZA-SCHOREY C, COOPER JA: Actin assembly at membranes controlled by ARF6. Traffic 1:896-907, 2000
41. WEAVER AM, KARGINOV AV, KINLEY AW, et al: Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol 11:370-374, 2001
42. KERJASCHKI D: Polycation-induced dislocation of slit diaphragms and formation of cell junctions in rat kidney glomeruli: the effects of low temperature, divalent cations, colchicine, and cytochalasin B. Lab Invest 39:430-440, 1978
43. PATRIE KM, DRESCHER AJ, WELIHINDA A, et al: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. J Biol Chem 277:30183-30190, 2002
44. PATRIE KM, DRESCHER AJ, GOYAL M, et al: The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. J Am Soc Nephrol 12:667-677, 2001
45. BEALL B, CHALOVICH JM: Fesselin, a synaptopodin-like protein, stimulates actin nucleation and polymerization. Biochemistry 40:14252-14259, 2001