Pair-rule gene runt restricts orthodenticle expression to the presumptive head of the Drosophila embryo

Developmental Genetics

Volumn 23, Issue 1, 1998, Pages 35-44

  Tsai, Chih Cheng ^a,b   Kramer, Sunita G ^a   Gergen, J Peter ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Blastoderm embryo; Groucho; Head gap gene; Runt; Tailless; Terminal group; Transcription; VWRPY

Indexed keywords

GENE PRODUCT; REPRESSOR PROTEIN;

ALLELE; ARTICLE; BLASTODERM; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY PATTERNING; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, INSECT; HOMEODOMAIN PROTEINS; MUTATION; NUCLEAR PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

HEXAPODA;

EID: 0031868929     PISSN: 0192253X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6408(1998)23:1<35::AID-DVG4>3.0.CO;2-7     Document Type: Article

References (50)

1. Andreazzoli M, Pannese M, Bonicelli E (1997): Activating and repressing signals in head development: the role of Xotx1 and Xotx2. Development 124:1733-1743.
2. Aronson BD, Fisher AL, Blechman K, Caudy M, Gergen JP (1997): Groucho-dependent and -independent repression activities of Runt domain proteins. Mol Cell Biol 17:5581-5587.
3. Bronner G, Jäckle H (1991): Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo. Mech Dev 35:205-211.
4. Coffman JA, Kirchhamer CV, Harrington MG, Davidon EH (1996): SpRunt-1, a new member of the runt domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos. Dev Biol 174:43-54.
5. Cohen SM, Jurgens G (1990): Mediation of Drosophila head development by gap-like segmentation genes. Nature 346:482-485.
6. Daga A, Karlovich CA, Dumstrei K, Banerjee U (1996): Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes Dev 10:1194-1205.
7. Dalton D, Chadwick R, McGinnis W (1989): Expression and embryonic function of empty spiracles: A Drosophila homeobox gene with two patterning functions on the anterior-posterior axis of the embryo. Genes Dev 3:1940-1956.
8. DiNardo S, O'Farrell P (1987): Establishment and refinement of segmental pattern in the Drosophila embryo: Spatial control of engrailed expression by pair-rule genes. Genes Dev 1:1212-1225.
9. Driever W, Nüsslein-Volhard C (1988): A gradient of bicoid protein in the Drosophila embryo. Cell 54:83-93.
10. Ducy P, Zhang R, Geoffrey V, Ridall AL, Karsenty G (1997): Osf2/ Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747-754.
11. Duffy JB, Gergen JP (1991): The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal. Genes Dev 5:2176-2187.
12. Duffy JB, Kania MA, Gergen JP (1991): Expression and function of the Drosophila gene runt in early stages of neural development. Development 113:1223-1230.
13. Finkelstein R, Perrimon N (1990): The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature 346:485-488.
14. Gao Q, Wang Y, Finkelstein R (1996): orthodenticle regulation during embryonic head development in Drosophila. Mech Dev 56:3-15.
15. Gergen JP, Butler BA (1988): Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis. Genes Dev 2:1179-1193.
16. Hoch M, Jäckle H (1993): Transcriptional regulation and spatial patterning in Drosophila. Curr Opin Genet Dev 3:566-573.
17. Hülskamp M, Schroeder C, Pfeifle C, Jäckle H, Tautz D (1989): Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene. Nature 338:629-632.
18. Ingham PW, Gergen JP (1988): Interactions between the pair-rule genes runt, hairy, even-skipped and fushi tarazu generate a molecular pre-pattern in the Drosophila embryo. Development 104 (suppl., Mechanisms of Segmentation):51-60.
19. Irish V, Lehmann R, Akam M (1989): The Drosophila posterior group gene nanos functions by repressing hunchback activity. Nature 338:646-648.
20. Kagoshima H, Shigesada K, Satake M, Ito Y, Miyoshi H, Ohki M, Pepling M, Gergen JP (1993): The Runt-domain identifies a new family of heteromeric transcriptional regulators. Trends Genet 9:338-341.
21. Klingler M, Erdélyi M, Szabad J, Nüsslein-Volhard C (1988): Function of torso in determining the terminal anlagen of the Drosophila embryo. Nature 335:275-277.
22. Klingler M, Gergen JP (1993): Regulation of runt transcription by Drosophila segmentation genes. Mech Dev 43:3-19.
23. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T (1997): Targeted disruption of Cbfal results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
24. Kornberg TB, Tabata T (1993): Segmentation of the Drosophila embryo. Curr Opin Genet Dev 3:585-593.
25. Lehmann R, Nüsslein-Volhard C (1986): Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in Drosophila. Cell 47:141-152.
26. Lehmann R, Nüsslein-Volhard C (1987): hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo. Dev Biol 119:402-417.
27. Liaw G-J, Rudolph KM, Huang J-D, Dubnicoff T, Courey AJ, Lengyel JA (1995): The torso response element binds GAGA and NTF-1/ Elf-1, and regulates tailless by relief of repression. Genes Dev 9:3163-3176.
28. Lowe CJ, Wray GA (1997): Radical alterations in the role of homeobox genes during echinoderm evolution. Nature 389:718-721.
29. Manoukian AS, Krause HM (1993): Control of segmental asymmetry in Drosophila embryos. Development 118:785-796.
30. Mohler J, Eldon ED, Pirrotta V (1989): A novel spatial transcription pattern associated with the segmentation gene giant of Drosophila. EMBO J 8:1539-1548.
31. Nauber U, Pankratz MJ, Kienlin A, Seifert E, Klemm U, Jäckle H (1988): Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps. Nature 336:489-492.
32. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR (1996): AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-330.
33. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GWH, Beddington RSP, Mundlos S, Olsen BR, Selby PB, Owen MJ (1997): Cbfa1, a candidate gene for cleidocrardal dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771.
34. Pignoni F, Baldarelli RM, Steingrimsson E, Diaz RJ, Patapoutian A, Merriam JR, Lengyel JA (1990): The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62:151-163.
35. Pignoni F, Steingrimmson E, Lengyel JA (1992): bicoid and the terminal system activate tailless expression in the early Drosophila embryo. Development 115:239-251.
36. Riddihough G, Ish-Horowicz D (1991): Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap and pair-rule genes. Genes Dev 5:840-854.
37. Speck NA, Stacy T (1995): Anew transcription factor family associated with human leukemias. Crit Rev Eukaryot Gene Expr 5:337-364.
38. Stanojevic D, Small S, Levine M (1991): Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo. Science 254:1385-1387.
39. Stevens LM, Frohnhöfer HG, Klingler M, Nüsslein-Volhard C (1990): Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo. Nature 346:660-663.
40. St Johnston D, Nüsslein-Volhard C (1992): The origin of pattern and polarity in the Drosophila embryo. Cell 68:201-219.
41. Strecker TR, Kongsuwan K, Lengyel JA, Merriam JR (1986): tailless, a zygotic mutant affecting the anterior and posterior regions of the Drosophila embryo. Dev Biol 113:64-76.
42. Struhl G (1989): Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos. Nature 338:741-744.
43. Tautz D (1988): Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centers. Nature 332:281-284.
44. Tracey WD, Pepling ME, Horb ME, Thomsen GH, Gergen JP (1998): A Xenopus homologue of AML1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood. Development 125:1371-1380.
45. Tsai C, Gergen JP (1994): Gap gene properties of the pair-rule gene runt during Drosophila segmentation. Development 120:1671-1683.
46. Tsai C, Gergen JP (1995): Pair-rule expression of the Drosophila fushi tarazu gene: A nuclear receptor response element mediates the opposing regulatory effects of runt and hairy. Development 121:453-462.
47. Wada S, Katsuyama Y, Sato Y, Itoh C, Saiga H (1996): Hroth an orthodenticle-related homeobox gene of the ascidian, Halocynthia roretzi: Its expression and putative roles in axis formation during embryogenesis. Mech Dev 60:59-71.
48. Wang Q, Stacy T, Binder M, Marín-Padilla M, Sharpe AH, Speck NA (1996): Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444-3449.
49. Weigel D, Jürgens G, Klingler M, Jäckle H (1990): Two gap genes mediate terminal pattern information in Drosophila. Science 248: 495-498.
50. Wieschaus E, Nüsslein-Volhard C, Kluding H (1984): Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation. Dev Biol 104:172-186.