Molecular characterization of uterine clear cell carcinoma

Modern Pathology

Volumn 17, Issue 5, 2004, Pages 530-537

  An, Hee Jung ^a   Logani, Sanjay ^b   Isacson, Christina ^c   Ellenson, Lora H ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b EMORY UNIVERSITY HOSPITAL   (United States)

^c VIRGINIA MASON MEDICAL CENTER   (United States)

Author keywords

Microsatellite instability; p53 mutation; PTEN mutation; Uterine clear cell carcinoma

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ARTICLE; CANCER CLASSIFICATION; CANCER GROWTH; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; CLINICAL FEATURE; CORRELATION ANALYSIS; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CARCINOMA; FEMALE; GENE; GENE MUTATION; GENETIC HETEROGENEITY; GROWTH REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSATELLITE INSTABILITY; MIXED SEROUS CARCINOMA; MOLECULAR BIOLOGY; MOLECULAR GENETICS; PATHOGENESIS; PRIORITY JOURNAL; PTEN GENE; UTERUS CARCINOMA;

ADENOCARCINOMA, CLEAR CELL; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 2; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MICROSATELLITE REPEATS; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEIN P53; UTERINE NEOPLASMS;

EID: 3042721642     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800057     Document Type: Article

References (29)

1. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-17.
2. Koul A, Willen R, Bendahl PO, et al. Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis. Cancer 2002;94: 2369-2379.
3. Lax SF, Kendall B, Tashiro H, et al. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 2000;88:814-824.
4. Sherman ME. Theories of endometrial carcinogenesis: a multidisciplinary approach. Mod Pathol 2000;13: 295-308.
5. Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997;57:3935-3940.
6. Catasus L, Machin P, Matias-Guiu X, et al. Microsatellite instability in endometrial carcinomas: clinicopathologic correlations in a series of 42 cases. Hum Pathol 1998;29:1160-1164.
7. Burks RT, Kessis TD, Cho KR, et al. Microsatellite instability in endometrial carcinoma. Oncogene 1994;9:1163-1166.
8. Duggan BD, Felix JC, Muderspach LI, et al. Microsatellite instability in sporadic endometrial carcinoma. J Natl Cancer Inst 1994;86:1216-1221.
9. Sherman ME, Bur ME, Kurman RJ. p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorigenesis. Hum Pathol 1995; 26:1268-1274.
10. Moll UM, Chalas E, Auguste M, et al. Uterine papillary serous carcinoma evolves via a p53-driven pathway. Hum Pathol 1996;27:1295-1300.
11. Lax SF, Pizer ES, Ronnett BM, et al. Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression. Hum Pathol 1998;29: 551-558.
12. Giri PG, Schneider V, Belgrad R. Clear cell carcinoma of the endometrium: an uncommon entity with a favorable prognosis. Int J Radiat Oncol Biol Phys 1981;7:1383-1387.
13. Cirisano Jr FD, Robboy SJ, Dodge RK, et al. The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma. Gynecol Oncol 2000;77:55-65.
14. Kurman RJ, Scully RE. Clear cell carcinoma of the endometrium: an analysis of 21 cases. Cancer 1976;37:872-882.
15. Bafna UD, Tasneem R. Long-term survival of an advanced stage clear cell carcinoma of the endometrium occurring in a young woman. J Obstet Gynaecol 2002;22:451-452.
16. Carcangiu ML, Chambers JT. Early pathologic stage clear cell carcinoma and uterine papillary serous carcinoma of the endometrium: comparison of clinicopathologic features and survival. Int J Gynecol Pathol 1995;14:30-38.
17. Abeler VM, Kjorstad KE. Clear cell carcinoma of the endometrium: a histopathological and clinical study of 97 cases. Gynecol Oncol 1991;40: 207-217.
18. Silverberg SG, De Giorgi LS. Clear cell carcinoma of the endometrium. Clinical, pathologic, and ultrastructural findings. Cancer 1973;31:1127-1140.
19. Sakuragi N, Hareyama H, Todo Y, et al. Prognostic significance of serous and clear cell adenocarcinoma in surgically staged endometrial carcinoma. Acta Obstet Gynecol Scand 2000;79:311-316.
20. Photopulos GJ, Carney CN, Edelman DA, et al. Clear cell carcinoma of the endometrium. Cancer 1979;43:1448-1456.
21. Malpica A, Tornos C, Burke TW, et al. Low-stage clear-cell carcinoma of the endometrium. Am J Surg Pathol 1995;19:769-774.
22. Kanbour-Shakir A, Tobon H. Primary clear cell carcinoma of the endometrium: a clinicopathologic study of 20 cases. Int J Gynecol Pathol 1991;10:67-78.
23. Christopherson WM, Alberhasky RC, Connelly PJ. Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma. Cancer 1982;49:1511-1523.
24. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-1947.
25. Levine RL, Cargile CB, Blazes MS, et al. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer Res 1998;58: 3254-3258.
26. Yaginuma Y, Yamashita T, Ishiya T, et al. Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. Mol Carcinogen 2000;27: 110-116.
27. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
28. Tashiro H, Lax SF, Gaudin PB, et al. Microsatellite instability is uncommon in uterine serous carcinoma. Am J Pathol 1997;150:75-79.
29. Risinger JI, Berchuck A, Kohler MF, et al. Genetic instability of microsatellites in endometrial carcinoma. Cancer Res 1993;53:5100-5103.