Mechanisms for the inhibition of genital vascular responses by antidepressants in a female rabbit model

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 1, 2004, Pages 141-149

  Angulo, Javier ^a   Cuevas, Pedro ^b   Cuevas, Begoña ^b   Gupta, Sandeep ^c   De Tejada, Iñigo Sáenz ^a,d  

^a Fund Invest/Desarrollo Androl   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c FOREST RESEARCH INSTITUTE   (United States)

^d NONE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; ARGININE; DULOXETINE; ESCITALOPRAM; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; NORADRENALIN UPTAKE INHIBITOR; PAROXETINE; PHENTOLAMINE MESYLATE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; VENLAFAXINE;

ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CLITORIS; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE GENITAL SYSTEM; MALE; NERVE STIMULATION; NONHUMAN; PELVIC NERVE; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RABBIT; VAGINA;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS; ARGININE; BLOOD VESSELS; CITALOPRAM; CYCLOHEXANOLS; DRUG INTERACTIONS; FEMALE; NITRIC OXIDE; NOREPINEPHRINE; PAROXETINE; PHENTOLAMINE; RABBITS; REGIONAL BLOOD FLOW; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; THIOPHENES; VAGINA; VASODILATION;

EID: 3042690300     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.063362     Document Type: Article

References (44)

1. Angulo J, Cuevas P, Cuevas B, Bischoff E, and Sáenz de Tejada I (2003) Vardenafil enhances clitoral and vaginal blood flow responses to pelvic nerve stimulation in female dogs. Int J Impot Res 15:137-141.
2. Angulo J, Cuevas P, Fernandez A, Gabancho S, and Sáenz de Tejada I (2001a) Combination ofphentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle. Urology 57: 585-589.
3. Angulo J, Peiro C, Sanchez-Ferrer CF, Gabancho S, Cuevas P, Gupta S, and Sáenz de Tejada I (2001b) Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production and neuronal NO synthase expression in rat corpus cavernosum tissue. Br J Pharmacol 134:1190-1194.
4. Arias F, Padin JJ, Rivas MT, and Sanchez A (2000) Sexual dysfunctions induced by serotonin reuptake inhibitors. Atención Primaria 26:389-394.
5. Berman JR, Adhikari SP, and Goldstein I (2000) Anatomy and physiology of female sexual function and dysfunction. Classification, evaluation and treatment options. Eur Urol 38:20-29.
6. Berman JR, Berman LA, Werbin TJ, Flaherty EE, Leahy NM, and Goldstein I (1999) Clinical evaluation of female sexual function: effects of age and estrogen status on subjective and physiologic sexual responses. Int J Impot Res 11 (Suppl 1):S31-S38.
7. Burnett AL, Calvin DC, Silver RI, Peppas DS, and Docimo SG (1997) Immunohistochemical description of nitric oxide synthase isoforms in human clitoris. J Urol 158:75-78.
8. Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, and Wong DT (2001) Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human seretonin receptor subtypes and other neuronal receptors. Neuropsychopharmacology 25:871-880.
9. Cellek S and Moncada S (1998) Nitrergic neurotransmission mediates the nonadrenergic responses in the clitoral corpus cavernosum of the rabbit. Br J Pharmacol 125:1627-1629.
10. Chalon SA, Granier LA, Vandenhende FR, Bieck PR, Bymaster FP, Joliat MJ, Hirth C, and Potter WZ (2003) Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study. Neuropsychopharmacology 28:1685-1693.
11. Detke MJ, Lu Y, Goldstein DJ, McNamara RK, and Demitrack MA (2002) Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression. J Psychiat Res 36:383-390.
12. Detke MJ, Wang F, Mallinckrodt CH, Tran PV, and Delgado PL (2003) Comparison of sexual functioning in patients receiving duloxetine or paroxetine: acute and long-term data. Poster presented at the 156th Annual Meeting of the American Psychiatric Association, 2003 May 17-22, San Francisco, CA. Abstract NR477.
13. Ereshefsky L (1996) Drug-drug interactions involving antidepressants: focus on venlafaxine. J Clin Psychopharmacol 16 (Suppl 2):37S-50S.
14. Finkel MS, Laghrissi-Thode F, Pollock BG, and Rong J (1996) Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull 32:653-658.
15. Giuliano F, Allard J, Compagnie S, Alexandre L, Droupy S, and Bernabe J (2001) Vaginal physiological changes in a model of sexual arousal in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 281:R140-R149.
16. Greenblatt DJ, von Moltke LL, Harmatz JS, and Shader RI (1998) Drug interactions with newer antidepressants: role of human cytochrome P450. J Clin Psychiatry 59 (Suppl 15):19-27.
17. Harvey AT, Rudolph RL, and Preskorn SH (2000) Evidence of the dual mechanisms of action of venlafaxine. Arch Gen Psychiatry 57:503-509.
18. Hovorka J, Herman E, and Nemcova II (2000) Treatment of interictal depression with citalopram in patients with epilepsy. Epilepsy Behav 1:444-447.
19. Hoyle CH, Stones RW, Robson T, Whitley K, and Burnstock G (1996) Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. J Anat 188:633-664.
20. Hull EM, Lorrain DS, Du J, Matuszewich L, Lumley LA, Putnam SK, and Moses J (1999) Hormone-neurotransmitter interactions in the control of sexual behavior. Behav Brain Res 105:105-116.
21. Kasamo K, Blier P, and De Montigny C (1996) Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J Pharmacol Exp Ther 277:278-286.
22. Kennedy SH, Eisfeld BS, Dickens SE, Bacchiochi JR, and Bagby RM (2000) Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline and venlafaxine. J Clin Psychiatry 61:276-281.
23. Kim NN, Min K, Huang YH, Goldstein I, and Traish AM (2002) Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina. Life Sci 71:2909-2920.
24. Kim SW, Jeong SJ, Munarriz R, Kim NN, Goldstein I, and Traish AM (2003) Role of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow. Int J Impot Res 15:355-361.
25. Labbate LA, Grimes J, Hines A, Oleshanky MA, and Arana GW (1998) Sexual dysfunction induced by serotonin reuptake antidepressants. J Sex Marital Ther 24:3-12.
26. Lepola UM, Loft H, and Reines EH (2003) Escitalopram (10-20 mg/day) is effective and well tolerated in a placebo-controlled study in depression in primary care. Int Clin Psychopharmacol 18:211-217.
27. Mendels J, Kiev A, and Fabre LF (1999) Double-blind comparison of citalopram and placebo in depressed outpatients with melancholia. Depress Anxiety 9:54-60.
28. Meston CM and Worcel M (2002) The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav 31:323-332.
29. Mork A, Kreilgaard M, and Sanchez C (2003) The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats. Neuropharmacology 45:167-173.
30. Morris JL and Gibbins IL (1992) Co-transmission and Neuromodulation, in Autonomic Neuroeffector Mechanisms (Burnstock G and Hoyle CHV eds) pp 33-120, Harwood Academic Publishers, Chur, Switzerland.
31. 2C receptors in regulation of female rat paced mating behavior. Behav Brain Res 149:151-157.
32. Norton PA, Zinner NR, Yalcin I, and Bump RC for the Duloxetine Urinary Incontinence Study Group (2002) Duloxetine versus placebo in the treatment of stress urinary incontinence. Am J Obstet Gynecol 187:40-48.
33. Owens MJ, Knight DL, and Nemeroff CB (2001) Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50:345-350.
34. Owens MJ, Morgan WN, Plott SJ, and Nemeroff CB (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
35. Preskorn SH (1993) Recent pharmacologic advances in antidepressant therapy for the elderly. Am J Med 94:2S-12S.
36. Rosen RC, Phillips NA, Gendrano NC 3rd, and Ferguson DM (1999) Oral phentolamine and female sexual arousal disorder: a pilot study. J Sex Marital Ther 25:137-144.
37. Rothschild AJ (1995) Selective serotonin reuptake inhibitor-induced sexual dysfunction: efficacy of a drug holiday. Am J Psychiatry 152:1514-1516.
38. Sanchez C, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, and Wiborg O (2003) Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology 167:353-362.
39. Skinner MH, Kuan HY, Pan A, Sathirakul K, Knadler MP, Gonzales CR, Yeo KP, Reddy S, Lim M, Ayan-Oshodi M, et al. (2003) Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers. Clin Pharmacol Ther 73:170-177.
40. Sommer F, Caspers HP, Esders K, Klotz T, and Engelmann U (2001) Measurement of vaginal and minor labial oxygen tension for the evaluation of female sexual function. J Urol 165:1181-1184.
41. von Moltke LL, Greenblatt DJ, Giancarlo GM, Granda BW, Harmatz JS, and Shader RI (2001) Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects and comparison to R-citalopram. Drug Metab Dispos 29:1102-1109.
42. Wang PS, Gilman SE, Guardino M, Christiana JM, Morselli PL, Michelson K, and Kessler RC (2000) Initiation of and adherence to treatment for mental disorders: examination of patient advocate group members in 11 countries. Med Care 38:926-936.
43. Zajecka J, Mitchell S, and Fawcett J (1997) Treatment-emergent changes in sexual function with selective serotonin reuptake inhibitors as measured with the Rush Sexual Inventory. Psychopharmacol Bull 33:755-760.
44. Ziessen T, Moncada S, and Cellek S (2002) Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. Br J Pharmacol 135:546-554.