Blockade of the serotonin and norepinephrine uptake processes by duloxetine: In vitro and in vivo studies in the rat brain

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 1, 1996, Pages 278-286

  Kasamo, Kimihiro ^a   Blier, Pierre ^a   De Montigny, Claude ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DESIPRAMINE; DULOXETINE; IDAZOXAN; NORADRENALIN; NORADRENALIN BITARTRATE; PAROXETINE; QUISQUALIC ACID; SEROTONIN; SEROTONIN CREATININE SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOPAMINE UPTAKE; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; DRUG MECHANISM; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SEROTONIN UPTAKE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BRAIN; IONTOPHORESIS; LOCUS COERULEUS; MALE; NOREPINEPHRINE; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; THIOPHENES;

EID: 0030424363     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. ADELL, A. AND ARTIGAS, F.: Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. Naunyn-Schmiedberg's Arch. Pharmacol. 343: 237-244, 1991.
2. AGHAJANIAN, G. K.: Feedback regulation of central monoaminergic neurons: Evidence from single-cell recording studies. In Essays in Neurochemistry and Neuropharmacology, ed. by M. B. H. Youdim, W. Lovenberg, D. F. Sharman and J. R. Lagnando, pp. 1-32, Wiley, New York, 1978.
3. BARKER, E. L. AND BLAKELY, R. D.: Norepinephrine and serotonin transporters: Molecular targets of antidepressant drugs. In Psychopharmacology: The Fourth Generation of Progress, ed. by F. E. Bloom and D. J. Kupfer, pp. 321-333, Raven Press, New York, 1995.
4. BJÖRKLUND, M. L., BAUMGARTEN, H. G. AND RENSCH, A.: 5,7-Dihydroxytryptamine: Improvement of its selectivity for serotonin neurons in the CNS by pretreatment with desipramine. J. Neurochem. 24: 833-835, 1975.
5. BLIER, P. AND DE MONTIGNY, C.: Current advances and trends in the treatment of depression. Trends Pharmacol. Sci. 15: 220-226, 1994.
6. BLIER, P., DE MONTIGNY, C. AND TARDIF, D.: Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system: Single-cells studies in the rat. Psychopharmacology 84: 242-249, 1984.
7. 1A receptors without altering 5-HT autoreceptor sensitivity: An electropysiological study in the rat brain. Synapse 1: 225-232, 1987.
8. BLIER, P., LISTA, A. AND DE MONTIGNY, C.: Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. J. Pharmacol. Exp. Ther. 265: 7-15, 1993.
9. BLIER, P., STEINBERG, S., CHAPUT, Y. AND DE MONTIGNY, C.: Electrophysiological assessment of putative antagonists of 5-HT receptors: A single-cell study in the rat dorsal raphe nucleus. Can. J. Physiol. Pharmacol. 67: 98-105, 1989.
10. BOYER, W. F. AND FEIGHNER, J. P.: The efficacy of selective serotonin re-uptake inhibitors in depression. In Selective Serotonin Re-uptake Inhibitors, ed. by J. P. Feighner and W. F. Boyer, pp. 89-108, John Wiley & Sons, Chichester, 1991.
11. CHAFUT, Y., DE MONTIGNY, C. AND BLIER, P.: Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain. Naunyn-Schmiedberg's Arch. Pharmacol. 333: 342-348, 1986.
12. COPPEN, A. J. AND DOOGAN, D. P.: Serotonin and its place in the pathogenesis of depression. J. Clin. Psychiatry 49: S4-S11, 1988.
13. DELGADO, P. L., CHARNEY, D. S., PRICE, L. H., AGHAJANIAN, G. K., LANDIS, H. AND HENINGER, G. R.: Serotonin function and the mechanism of antidepressant action. Arch. Gen. Psychiatry 47: 411-418, 1990.
14. DE MONTIGNY, C., WANG, R. Y., READER, T. A. AND AGHAJANIAN, G. K: Monoaminergic denervation of the rat hippocampus: Microiontophoretic studies on pre- and post synaptic supersensitivity to norepinephrine and serotonin. Brain Res. 200: 363-376, 1980.
15. DE MONTIGNY, C., BLIER, P., CAILLÉ, G. AND KOUASSI, E.: Pre- and postsynaptic effects of zimelidine and norzimelidine on the serotonergic system: Single cell studies in the rat. Acta Psychiatr. Scand. 63: S79-S80, 1981.
16. 2-adrenoceptors. Br. J. Pharmacol. 78: 489-505, 1983.
17. ENGLEMAN, E. A , PERRY, K. W., MAYLE, D. A. AND WONG, D. T.: Simultaneous increases of extracellular monoamines in microdyalysates from hypothalamus of conscious rats by duloxetine, a dual serotonin and norepinephrine uptake inhibitor. Neuropsychopharmacology 12: 287-296, 1995.
18. 2-adrenoceptors on rat central neurons. Eur. J. Pharmacol. 105: 265-272, 1984.
19. FULLER, R. W., SUSAN, K., HEMRICK-LUECKE AND SNODDY, H. D.: Effects of duloxetine, an antidepressant drug candidate, on concentrations of monoamines and their metabolites in rats and mice. J. Pharmacol. Exp. Ther. 269: 132-136, 1994.
20. GRAVEL, P. AND DE MONTIGNY, C.: Noradrenergic denervation prevents sensitization of rat forebrain neurons to tricyclic antidepressant treatment. Synapse 1: 133-139, 1987.
21. HAIGLER, H. J. AND AGHAJANIAN, G. K.: Lysergic acid diethylamide and serotonin: A comparison of effects on serotonergic neurons and neurons receiving a serotonergic input. J. Pharmacol. Exp. Ther. 188: 688-699, 1974.
22. KANDEL, E. R. AND SPENCER W. A.: Electrophysiology of hippocampal neurons. II. After potentials and repetitive firing. J. Neurophysiol. 24: 243-259, 1961.
23. KIHARA, T. AND IKEDA, M.: Effects of duloxetine, a new serotonin and norepinephrine uptake inhibitor, on extracellular monoamine levels in rat frontal cortex. J. Pharmacol. Exp. Ther. 272: 177-183, 1995.
24. MCRAE-DEOUEURCE, A., BEROD, A , MERMET, A., KELLER, A., CHOUVET, G., JOH, T. H. AND PUJOL, J. F.: Alterations in tyrosine hydroxylase activity elicited by raphe nuclei lesions in the rat locus coeruleus: Evidence for the involvement of serotonin afferents. Brain Res. 235: 285-301, 1982.
25. MELTZER, H. Y. AND LOWY, M. T.: The serotonin hypothesis of depression. In Psychopharmacology: The Third Generation of Progress, ed. by H. Y. Meltzer, pp. 513-526, Raven Press, New York, 1987.
26. NELSON, J. C., MAZURE, C. M., BOWERS, M. B. AND JATLOW, P I.: A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression. Arch. Gen. Psychiatry 48: 303-307, 1991.
27. OLESKEVICH, S. AND DESCARRIES, L.: Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience 34: 19-13, 1990.
28. PAZOS, A. AND PALACIOS, J. M.: Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346: 205-203, 1985.
29. PICKEL, V. M., JOH, T. H. AND REIS D. J.: A serotonergic innervation of noradrenergic neurons in nucleus locus coeruleus: Demonstration by immunocytochemical localization of the transmitter specific enzymes tyrosine and tryptophan hydroxylase. Brain Res. 131: 197-214, 1977.
30. PIÑEYRO, G., BLIER, P., DENNIS, T. AND DE MONTIGNY, C.: Desensitization of the neuronal 5- HT carrier following its long-term blockade. J. Neurosci. 14: 3036-3047, 1994.
31. RANCK, J. B., JR.: Studies of single neurons in dorsal hippocampal formation and septum in unrestrained rats. I. Behavioral and firing repertoires. Exp. Neurol. 41: 461-531, 1973.
32. RUTTER J. J. AND AUERBACH S. B.: Acute uptake inhibition increases extracellular serotonin in the rat forebrain. J. Pharmacol. Exp. Ther. 265: 1319-1324.
33. SCUVÉE-MOREAU, J. J. AND DRESSE, A. E.: Effect of various antidepressant drugs on the spontaneous firing rate of locus coeruleus and dorsal raphe neurons of the rat. Eur. J. Pharmacol. 57: 219-225, 1979.
34. SEGAL, M.: Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on responses to noxious stimuli. J. Physiol. (Lond.) 286: 401-415, 1979.
35. SETH, R., JENNINGS, A. L., BINDMAN, J., PHILLIPS, J. AND BERGMANN, K.: Combination treatment with noradrenaline and serotonin reuptake inhibitors in resistant depression. Br. J. Psychiatry 161: 562-565, 1992.
36. 1A selective agonists. Eur. J. Pharmacol. 128: 295-298, 1986.
37. 1B agonists. Synapse 1: 3-9, 1987.
38. SVENSSON, T. H. AND USDIN, E.: Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: α-receptor mediation Science 202: 1089-1091, 1978.
39. TOLLEFSON, G. D., TOMPSON, R. G., HEILIGENSTEIN, J. H., JAMES, S., WONG, D. T., FARIES, D. E. AND HYSLOP, D. L.: Is the potent, dual uptake inhibition of norepinephrine and serotonin by LY248686 (duloxetine) associated with a more rapid and robust antidepressant response? Am. Coll. Neuropsychopharmacol. 32: 23, 1993.
40. VERGÉ, D., DAVAL, G., PATEY, A., GOZLAN, H., EL MESTIKAWY, S. AND HAMON, M.: Presynaptic 5-HT autoreceptor on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur. J. Pharmacol. 113: 463-464, 1985.
41. 1A binding sites on serotonin-containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochem. Int. 7: 1061-1072, 1985.
42. WONG, D. T., BYMASTER, F. P., MAYLE, D. A., REID, L. R., KURSHINSKI, J. H. AND ROBERTSON, D. W.: LY248686, a new inhibitor of serotonin and norepinephrine uptake. Neuropsychopharmacology 8: 23-33, 1993.