Blood-brain barrier permeability of novel [D-Arg2]dermorphin (1-4) analogs: Transport property is related to the slow onset of antinociceptive activity in the central nervous system

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 1, 2004, Pages 177-184

  Deguchi, Yoshiharu ^a   Naito, Yu ^b   Ohtsuki, Sumio ^c,f   Miyakawa, Yusaku ^b   Morimoto, Kazuhiro ^b   Hosoya, Ken Ichi ^e,f   Sakurada, Shinobu ^d   Terasaki, Tetsuya ^c,f  

^a TEIKYO UNIVERSITY   (Japan)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF TOYAMA   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; DANSYLCADAVERINE; DERMORPHIN DERIVATIVE; IODINE 125; MU OPIATE RECEPTOR AGONIST; NALPHA AMIDINOTYROSYL DEXTRO ARGINYLPHENYLALANYL BETA ALANINE; NALPHA AMIDINOTYROSYL DEXTRO ARGINYLPHENYLALANYLMETHIONYL BETA ALANINE; POLYCATION; POLYLYSINE; PROTAMINE; TYROSYL DEXTRO ARGINYLPHENYLALANYL BETA ALANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BLOOD BRAIN BARRIER; CELL CULTURE; CENTRAL NERVOUS SYSTEM; DRUG STRUCTURE; ENDOCYTOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; DRUG INTERACTIONS; ENDOCYTOSIS; IODINE RADIOISOTOPES; MICE; MORPHINE; OLIGOPEPTIDES; OPIOID PEPTIDES; PERMEABILITY; RADIOLIGAND ASSAY; TEMPERATURE;

EID: 3042685990     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.064006     Document Type: Article

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