Different mechanisms influencing permeation of PDGF-AA and PDGF-BB across the blood-brain barrier

Journal of Neurochemistry

Volumn 87, Issue 1, 2003, Pages 7-12

  Kastin, Abba J ^a,b   Akerstrom, Victoria ^a   Hackler, Laszlo ^a   Pan, Weihong ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; Capillary electrophoresis; HPLC; Hydrogen bonding; Platelet derived growth factor; Protein binding

Indexed keywords

ALBUMIN TC 99M; IODINE 125; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR BB;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CAPILLARY ELECTROPHORESIS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; LIPOPHILICITY; MALE; MOUSE; NEUROMODULATION; NEUROTROPISM; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CEREBROVASCULAR CIRCULATION; ELECTROPHORESIS, CAPILLARY; HYDROGEN BONDING; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; MALE; MICE; OCTANOLS; PLATELET-DERIVED GROWTH FACTOR;

ANIMALIA;

EID: 0141866671     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01933.x     Document Type: Article

References (19)

1. Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T. and Matsuzawa Y. (2002) Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105, 2893-2898.
2. Chikhale E. G., Burton P. S. and Borchardt R. T. (1995) The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism. J. Pharmacol. Exp Ther 273, 298-303.
3. Jean I., Allamargot C., Barthelaix-Pouplard A. and Fressinaud C. (2002) Axonal lesions and PDGF-enhanced remyelination in the rat corpus callosum after lysilecithin demyelination. Neuroreport 13, 627-631.
4. Kastin A. J. and Akerstrom V. (1999a) Entry of CART into brain is rapid but not inhibited by excess CART or leptin. Am. J. Physiol. 277, E901-E904.
5. Kastin A. J. and Akerstrom V. (1999b) Nonsaturable entry of neuropeptide Y into the brain. Am. J. Physiol. 276, E479-E482.
6. Kastin A. J. and Akerstrom V. (2000) Mahogany (1377-1428) enters brain by a saturable transport system. J. Pharmacol. Exp. Ther. 294, 633-636.
7. Kastin A. J., Akerstrom V. and Hackler L. (2000a) Agouti-related protein (83-132) aggregates and crosses the blood-brain barrier slowly. Metabolism 49, 1444-1448.
8. 19-Melanin-concentrating hormone and the blood-brain barrier: role of protein binding. J. Neurochem. 74, 385-391.
9. Kastin A. J., Akerstrom V. and Hackler L. (2001a) Food deprivation decreases blood galanin-like peptide and its rapid entry into the brain. Neuroendocrinology 74, 423-432.
10. Kastin A. J., Akerstrom V., Hackler L. and Pan W. (2001b) Adrenomedullin and the blood-brain barrier. Hormones Metab. Res. 33, 19-25.
11. Kastin A. J., Akerstrom V. and Pan W. (2001c) Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22, 2127-2136.
12. Kastin A. J., Akerstrom V. and Pan W. (2002) Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Molec. Neurosci. 18, 7-14.
13. Krupinski J., Issa R., Bujny T., Slevin M., Kumar P., Kumar S. and Kaluza J. (1997) A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans. Stroke 28, 564-573.
14. Maness L. M., Kastin A. J., Farrell C. L. and Banks W. A. (1998) Fate of leptin after intracerebroventricular injection into mouse brain. Endocrinology 139, 4556-4562.
15. Pela I. R., Ferreira M. E. S., Melo M. C. C., Silva C. A. A., Coelho M. M. and Valenzuela C. F. (2000) Evidence that platelet-derived growth factor may be a novel endogenous pyrogen in the central nervous system. Am. J. Physiol. 278, R1275-R1281.
16. Plata-Salaman C. R. (1988) Food intake suppression by growth factors and platelet peptides by direct action in the central nervous system. Neurosci. Lett. 94, 161-166.
17. Sasaki K., Oomura Y., Suzuki K., Muto T., Hanai K., Tooyama I., Kimura H. and Yanaihara N. (1991) Effects of fibroblast growth factors and platelet-derived growth factor on food intake in rats. Brain Res. Bull. 27, 327-332.
18. Smits A., Hermansson M., Nister M., Kamushina I., Heldin C. H., Westermark B. and Funa K. (1989) Rat brain capillary endothelial cells express functional PDGF B-type receptors. Growth Factors 2, 1-8.
19. Valenzuela C. F., Kazlauskas A. and Weiner J. L. (1997) Roles of platelet-derived growth factor in the developing and mature nervous systems. Brain Res. Rev. 24, 77-89.