메뉴 건너뛰기




Volumn 6, Issue 2, 2004, Pages 119-125

Novel therapies for pancreatic adenocarcinoma

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; BEVACIZUMAB; BORTEZOMIB; CELECOXIB; CETUXIMAB; CYCLOOXYGENASE 2 INHIBITOR; ENDOSTATIN; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ERLOTINIB; FUMAGILLOL CHLOROACETYLCARBAMATE; GEMCITABINE; IMMUNOGLOBULIN G ANTIBODY; LONAFARNIB; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; PELITINIB; PROTEASOME INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; ROFECOXIB; SUNITINIB; TANOMASTAT; TIPIFARNIB; TRASTUZUMAB; UNINDEXED DRUG; VANDETANIB; VATALANIB; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; COMPLEMENTARY RNA; CYSTEINE PROTEINASE; DEOXYCYTIDINE; DRUG DERIVATIVE; EPIDERMAL GROWTH FACTOR; HYDROXAMIC ACID; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; MULTIENZYME COMPLEX; PROTEASOME; PROTEIN TYROSINE KINASE;

EID: 3042628477     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-004-0038-x     Document Type: Review
Times cited : (15)

References (50)
  • 2
    • 0035841631 scopus 로고    scopus 로고
    • Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomized controlled trial
    • Neoptolemos JP, Dunn JA, Stocken DD, et al.: Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomized controlled trial. Lancet 2001, 358:1576-1585.
    • (2001) Lancet , vol.358 , pp. 1576-1585
    • Neoptolemos, J.P.1    Dunn, J.A.2    Stocken, D.D.3
  • 3
    • 0035841605 scopus 로고    scopus 로고
    • Continuing controversy over adjuvant therapy of pancreatic cancer
    • Abrams RA, Lillemoe KD, Plantadosi S: Continuing controversy over adjuvant therapy of pancreatic cancer. Lancet 2001, 358:1565-1566.
    • (2001) Lancet , vol.358 , pp. 1565-1566
    • Abrams, R.A.1    Lillemoe, K.D.2    Plantadosi, S.3
  • 4
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA, Moore MJ, Andersen J, et al.: Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997, 15:2403-2413.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 5
    • 0001869608 scopus 로고    scopus 로고
    • New developments in the treatment of patients with pancreatic cancer
    • Von Hoff D, Mahadevan D, Bearss D: New developments in the treatment of patients with pancreatic cancer. Clin Oncol Updates 2001, 4:1-15.
    • (2001) Clin. Oncol. Updates , vol.4 , pp. 1-15
    • Von Hoff, D.1    Mahadevan, D.2    Bearss, D.3
  • 6
    • 0028157921 scopus 로고
    • Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins
    • Lohr M, Trautmann B, Gottler M, et al.: Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins. Br J Cancer 1994, 69:144-151.
    • (1994) Br. J. Cancer , vol.69 , pp. 144-151
    • Lohr, M.1    Trautmann, B.2    Gottler, M.3
  • 7
    • 0028291737 scopus 로고
    • A matrix metalloproteinase expressed on the surface of invasive tumor cells
    • Sato H, Takino T, Okada Y, et al.: A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature 1994, 370:61-65.
    • (1994) Nature , vol.370 , pp. 61-65
    • Sato, H.1    Takino, T.2    Okada, Y.3
  • 8
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Bramhall SR, Rosemurgy A, Brown PD, et al.: Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol 2001, 19:3447-3455.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3
  • 9
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, et al.: A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002, 87(Suppl 2):61-167.
    • (2002) Br. J. Cancer , vol.87 , Issue.SUPPL. 2 , pp. 61-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 10
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 129566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Hamm J, Dancey J, et al.: Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 129566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003, 21:3296-3302.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3
  • 11
    • 0035425424 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition of pancreatic cancer: Matching mechanism of action to clinical trial design
    • Hess KR, Abbruzzese JL: Matrix metalloproteinase inhibition of pancreatic cancer: matching mechanism of action to clinical trial design. J Clin Oncol 2001, 19:3445-3446.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3445-3446
    • Hess, K.R.1    Abbruzzese, J.L.2
  • 12
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • Hruban RH, Van Mansfeld AD, Offerhaus GJ, et al.: K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993, 143:545-554.
    • (1993) Am. J. Pathol. , vol.143 , pp. 545-554
    • Hruban, R.H.1    Van Mansfeld, A.D.2    Offerhaus, G.J.3
  • 13
    • 0035908493 scopus 로고    scopus 로고
    • Blocking oncogenic ras signalling for cancer therapy
    • Adjei AA: Blocking oncogenic ras signalling for cancer therapy. J Natl Cancer Inst 2001, 93:1062-1074.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1062-1074
    • Adjei, A.A.1
  • 15
    • 0002989445 scopus 로고    scopus 로고
    • Randomized phase II study of SCH 66336 and gemcitabine in the treatment of metastatic adenocarcinoma of the pancreas
    • [abstract]
    • Lersch C, Van Cutsem E, Amado R, et al.: Randomized phase II study of SCH 66336 and gemcitabine in the treatment of metastatic adenocarcinoma of the pancreas [abstract]. Proc ASCO 2001, 20:608.
    • (2001) Proc. ASCO , vol.20 , pp. 608
    • Lersch, C.1    Van Cutsem, E.2    Amado, R.3
  • 16
    • 0001120709 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG)
    • [abstract]
    • Macdonald JS, Chansky K, Whitehead R, et al.: A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest Oncology Group (SWOG) [abstract]. Proc ASCO 2002, 21:548.
    • (2002) Proc. ASCO , vol.21 , pp. 548
    • Macdonald, J.S.1    Chansky, K.2    Whitehead, R.3
  • 17
    • 0038413837 scopus 로고    scopus 로고
    • Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma
    • Cohen SJ, Ho L, Ranganathan S, et al.: Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. J Clin Oncol 2003, 21:1301-1306.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1301-1306
    • Cohen, S.J.1    Ho, L.2    Ranganathan, S.3
  • 18
    • 0000324578 scopus 로고    scopus 로고
    • Phase III trial comparing gemcitabine + R115777 (Zarnestra) versus gemcitabine + placebo in advanced pancreatic cancer (PC)
    • [abstract]
    • Van Cutsem E, Karasek P, Oettle H, et al.: Phase III trial comparing gemcitabine + R115777 (Zarnestra) versus gemcitabine + placebo in advanced pancreatic cancer (PC) [abstract]. Proc ASCO 2002, 21:517.
    • (2002) Proc. ASCO , vol.21 , pp. 517
    • Van Cutsem, E.1    Karasek, P.2    Oettle, H.3
  • 19
    • 0037010076 scopus 로고    scopus 로고
    • Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia
    • Arteaga CL: Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin Oncol 2002, 29:3-9.
    • (2002) Semin. Oncol. , vol.29 , pp. 3-9
    • Arteaga, C.L.1
  • 20
    • 0030740155 scopus 로고    scopus 로고
    • Amphiregulin antisense oligonucleotide inhibits growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy
    • Funatomi H, Itakura J, Ishiwata T, et al.: Amphiregulin antisense oligonucleotide inhibits growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy. Int J Cancer 1997, 72:512-517.
    • (1997) Int. J. Cancer , vol.72 , pp. 512-517
    • Funatomi, H.1    Itakura, J.2    Ishiwata, T.3
  • 21
    • 0020933452 scopus 로고
    • Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
    • Sato JD, Kawamoto T, Le AD, et al.: Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1983, 1:511-529.
    • (1983) Mol. Biol. Med. , vol.1 , pp. 511-529
    • Sato, J.D.1    Kawamoto, T.2    Le, A.D.3
  • 22
    • 0034114769 scopus 로고    scopus 로고
    • BIockade of receptors for growth factors: An anticancer therapy: The fourth annual Joseph H. Burchenal American Association for Cancer Research Clinical Research Award Lecture
    • Mendelsohn J: BIockade of receptors for growth factors: an anticancer therapy: the fourth annual Joseph H. Burchenal American Association for Cancer Research Clinical Research Award Lecture. Clin Cancer Res 2000, 6:747-753.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 747-753
    • Mendelsohn, J.1
  • 23
    • 18844473781 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
    • Bruns CJ, Harbison MT, Davis DW, et al.: Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res 2000, 6:1936-1948.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1936-1948
    • Bruns, C.J.1    Harbison, M.T.2    Davis, D.W.3
  • 24
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns CJ, Solorzano CC, Harbison MT, et al.: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 2000, 60:2926-2935.
    • (2000) Cancer Res. , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3
  • 25
    • 0001391575 scopus 로고    scopus 로고
    • Phase II study of anti-epidermal growth factor receptor (EGFR) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer
    • [abstract]
    • Abbruzzese J, Rosenberg A, Xiong Q, et al.: Phase II study of anti-epidermal growth factor receptor (EGFR) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer [abstract]. Proc ASCO 2001, 20:518.
    • (2001) Proc. ASCO , vol.20 , pp. 518
    • Abbruzzese, J.1    Rosenberg, A.2    Xiong, Q.3
  • 26
    • 0000616471 scopus 로고    scopus 로고
    • Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER2/neu
    • [abstract]
    • Safran H, Ramanathan RK, Schwartz J, et al.: Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER2/neu [abstract]. Proc ASCO 2001, 20:517.
    • (2001) Proc. ASCO , vol.20 , pp. 517
    • Safran, H.1    Ramanathan, R.K.2    Schwartz, J.3
  • 27
    • 0000453534 scopus 로고    scopus 로고
    • EKB-569: A new irreversible inhibitor of epidermal growth factor receptor tyrosine kinase for the treatment of cancer
    • [abstract]
    • Greenberger LM, Discafani C, Wang YF, et al.: EKB-569: a new irreversible inhibitor of epidermal growth factor receptor tyrosine kinase for the treatment of cancer [abstract]. Clin Cancer Res 2000, 6:4544s.
    • (2000) Clin. Cancer Res. , vol.6
    • Greenberger, L.M.1    Discafani, C.2    Wang, Y.F.3
  • 28
    • 0345203994 scopus 로고    scopus 로고
    • Preliminary report of a phase 1 study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), given in combination with gemcitabine to patients with advanced pancreatic cancer
    • [abstract]
    • Morgan JA, Bukowski RM, Xiong H, et al.: Preliminary report of a phase 1 study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), given in combination with gemcitabine to patients with advanced pancreatic cancer [abstract]. Proc ASCO 2003, 22:788.
    • (2003) Proc. ASCO , vol.22 , pp. 788
    • Morgan, J.A.1    Bukowski, R.M.2    Xiong, H.3
  • 29
    • 0033199017 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs
    • Molina MA, Sitja-Arnau M, Lemoine MG, et al.: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res 1999, 59:4356-4362.
    • (1999) Cancer Res. , vol.59 , pp. 4356-4362
    • Molina, M.A.1    Sitja-Arnau, M.2    Lemoine, M.G.3
  • 30
    • 0033963927 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in human pancreatic adenocarcinomas
    • Yip-Schneider MT, Barnard DS, Billings SD, et al.: Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. Carcinogenesis 2000, 21:139-146.
    • (2000) Carcinogenesis , vol.21 , pp. 139-146
    • Yip-Schneider, M.T.1    Barnard, D.S.2    Billings, S.D.3
  • 31
    • 0034883045 scopus 로고    scopus 로고
    • Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells
    • Yip-Schneider MT, Sweeney CJ, Jung SH, et al.: Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther 2001, 298:976-985.
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 976-985
    • Yip-Schneider, M.T.1    Sweeney, C.J.2    Jung, S.H.3
  • 32
    • 0038718799 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3′-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac
    • Yip-Schneider MT, Wiesenauer CA, Schmidt CM: Inhibition of the phosphatidylinositol 3′-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac. J Gastrointest Surg 2003, 7:354-363.
    • (2003) J. Gastrointest. Surg. , vol.7 , pp. 354-363
    • Yip-Schneider, M.T.1    Wiesenauer, C.A.2    Schmidt, C.M.3
  • 33
    • 0034161878 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors
    • Masferrer JL, Leahy KM, Koki AT, et al.: Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res 2000, 60:1306-1311.
    • (2000) Cancer Res. , vol.60 , pp. 1306-1311
    • Masferrer, J.L.1    Leahy, K.M.2    Koki, A.T.3
  • 34
    • 0036468287 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    • Leahy KM, Ornberg RL, Wang Y, et al.: Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res 2002, 62:625-631.
    • (2002) Cancer Res. , vol.62 , pp. 625-631
    • Leahy, K.M.1    Ornberg, R.L.2    Wang, Y.3
  • 35
    • 0038561540 scopus 로고    scopus 로고
    • Parmacology study of celecoxib in combination with gemcitabine for advanced pancreatic cancer
    • [abstract]
    • Xiong HQ, Du M, Wolff RA, et al.: Parmacology study of celecoxib in combination with gemcitabine for advanced pancreatic cancer [abstract]. Proc ASCO 2002, 21:448.
    • (2002) Proc. ASCO , vol.21 , pp. 448
    • Xiong, H.Q.1    Du, M.2    Wolff, R.A.3
  • 36
    • 3142682141 scopus 로고    scopus 로고
    • Preliminary report of a phase II trial of gemcitabine combined with celecoxib for advanced pancreatic cancer
    • [abstract]
    • Smith SE, Burris HA, Loehrer PJ, et al.: Preliminary report of a phase II trial of gemcitabine combined with celecoxib for advanced pancreatic cancer [abstract]. Proc ASCO 2003, 22:1502.
    • (2003) Proc. ASCO , vol.22 , pp. 1502
    • Smith, S.E.1    Burris, H.A.2    Loehrer, P.J.3
  • 37
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 39
    • 1642393197 scopus 로고    scopus 로고
    • Bevacizumab (B) plus gemcitabine (G) in patients (pts) with advanced pancreatic cancer (PC)
    • [abstract]
    • Kindler HL, Ansari R, Lester E, et al.: Bevacizumab (B) plus gemcitabine (G) in patients (pts) with advanced pancreatic cancer (PC) [abstract]. Proc ASCO 2003, 22:1037.
    • (2003) Proc. ASCO , vol.22 , pp. 1037
    • Kindler, H.L.1    Ansari, R.2    Lester, E.3
  • 40
    • 0034885358 scopus 로고    scopus 로고
    • New insights into the role of nuclear factor B in cell growth regulation
    • Chen F, Castranova V, Shi X: New insights into the role of nuclear factor B in cell growth regulation. Am J Pathol 2001, 159:387-397.
    • (2001) Am. J. Pathol. , vol.159 , pp. 387-397
    • Chen, F.1    Castranova, V.2    Shi, X.3
  • 41
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor B ReIA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, et al.: The nuclear factor B ReIA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999, 59:119-127.
    • (1999) Clin. Cancer Res. , vol.59 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3
  • 42
    • 0001100607 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic phase 1 study of PS-341 and gemcitabine in patients with advanced solid tumors
    • [abstract]
    • Ryan DP, Elder JP, Winkelmann J, et al.: Pharmacokinetic and pharmacodynamic phase 1 study of PS-341 and gemcitabine in patients with advanced solid tumors [abstract]. Proc ASCO 2002, 21:379.
    • (2002) Proc. ASCO , vol.21 , pp. 379
    • Ryan, D.P.1    Elder, J.P.2    Winkelmann, J.3
  • 43
    • 0034213130 scopus 로고    scopus 로고
    • Closing the gastrin loop in pancreatic carcinoma: Coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma
    • Goeze JP, Nielsen FC, Burcharth F, et al.: Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 2000, 88:2487-2494.
    • (2000) Cancer , vol.88 , pp. 2487-2494
    • Goeze, J.P.1    Nielsen, F.C.2    Burcharth, F.3
  • 44
    • 0030020865 scopus 로고    scopus 로고
    • Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer
    • Watson SA, Michaeli D, Grimes S, et al.: Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res 1996, 56:880-885.
    • (1996) Cancer Res. , vol.56 , pp. 880-885
    • Watson, S.A.1    Michaeli, D.2    Grimes, S.3
  • 45
    • 0003225821 scopus 로고    scopus 로고
    • G17DT therapy may improve the survival of patients with advanced pancreatic carcinoma
    • [abstract]
    • Gilliam AD, Henwood M, Watson SA, et al.: G17DT therapy may improve the survival of patients with advanced pancreatic carcinoma [abstract]. Proc ASCO 2001, 20:533.
    • (2001) Proc. ASCO , vol.20 , pp. 533
    • Gilliam, A.D.1    Henwood, M.2    Watson, S.A.3
  • 47
    • 0026774939 scopus 로고
    • Selective inhibition of mutant H-ras MRNA expression by antisense oligonucleotides
    • Monia BP, Johnston DJ, Ecker DJ, et al.: Selective inhibition of mutant H-ras MRNA expression by antisense oligonucleotides. J Biol Chem 1992, 267:19954-19962.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19954-19962
    • Monia, B.P.1    Johnston, D.J.2    Ecker, D.J.3
  • 48
    • 0029903628 scopus 로고    scopus 로고
    • Antisense oligonucleotides demonstrate a dominant role of c-Ki-ras proteins in regulating the proliferation of diploid human fibroblasts
    • Chen G, Oh S, Monia BP, et al.: Antisense oligonucleotides demonstrate a dominant role of c-Ki-ras proteins in regulating the proliferation of diploid human fibroblasts. J Biol Chem 1996, 271:28259-28265.
    • (1996) J. Biol. Chem. , vol.271 , pp. 28259-28265
    • Chen, G.1    Oh, S.2    Monia, B.P.3
  • 49
    • 3142699763 scopus 로고    scopus 로고
    • Gemcitabine and ISIS-2504 for patients with pancreatic adenocarcinoma (ACA): A North Central Cancer Treatment Group (NCCTG) phase II study
    • [abstract]
    • Burch PA, Alberts SR, Schroeder MT, et al.: Gemcitabine and ISIS-2504 for patients with pancreatic adenocarcinoma (ACA): A North Central Cancer Treatment Group (NCCTG) phase II study [abstract]. Proc ASCO 2003, 22:1038.
    • (2003) Proc. ASCO , vol.22 , pp. 1038
    • Burch, P.A.1    Alberts, S.R.2    Schroeder, M.T.3
  • 50
    • 0037314610 scopus 로고    scopus 로고
    • A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
    • Hecht JR, Bedford R, Abbruzzese JL, et al.: A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res 2003, 9:555-561.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 555-561
    • Hecht, J.R.1    Bedford, R.2    Abbruzzese, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.