메뉴 건너뛰기




Volumn 5, Issue 2, 2004, Pages 71-81

The role of aldosterone and aldosterone-receptor antagonists in heart failure

Author keywords

Aldosterone; Aldosterone receptor antagonist; Congestive heart failure; Eplerenone; Spironolactone

Indexed keywords

ALDOSTERONE; ALDOSTERONE ANTAGONIST; ALDOSTERONE RECEPTOR; ANGIOTENSIN; ANGIOTENSIN I; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAPTOPRIL; COLLAGEN; DIGITALIS; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; EPLERENONE; LISINOPRIL; LOOP DIURETIC AGENT; MESSENGER RNA; NEUROHORMONE; PLACEBO; POTASSIUM SPARING DIURETIC AGENT; RENIN; SODIUM; SPIRONOLACTONE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 3042616446     PISSN: 15306550     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (18)

References (69)
  • 1
    • 0033621141 scopus 로고    scopus 로고
    • Mechanisms and models in heart failure: A combinatorial approach
    • Mann DL. Mechanisms and models in heart failure: a combinatorial approach. Circulation. 1999;100:999-1008.
    • (1999) Circulation , vol.100 , pp. 999-1008
    • Mann, D.L.1
  • 2
    • 0025088737 scopus 로고
    • Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality
    • For the CONSENSUS Trial Study Group
    • Swedberg K, Eneroth F, Kjekshus J, Wilhelmsen L, for the CONSENSUS Trial Study Group. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. Circulation. 1990;82:1730-1736.
    • (1990) Circulation , vol.82 , pp. 1730-1736
    • Swedberg, K.1    Eneroth, F.2    Kjekshus, J.3    Wilhelmsen, L.4
  • 3
    • 0034426755 scopus 로고    scopus 로고
    • Role of beta-blockers in congestive heart failure
    • Khan NU, Movahed A. Role of beta-blockers in congestive heart failure. Congest Heart Fail. 2000;6:299-312.
    • (2000) Congest Heart Fail , vol.6 , pp. 299-312
    • Khan, N.U.1    Movahed, A.2
  • 4
    • 0019967321 scopus 로고
    • Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscle
    • Weber MA, Purdy RE. Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscle. Life Sci. 1982;30:2009-2017.
    • (1982) Life Sci. , vol.30 , pp. 2009-2017
    • Weber, M.A.1    Purdy, R.E.2
  • 5
    • 0030870613 scopus 로고    scopus 로고
    • Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients
    • MacFayden RJ, Barr CS, Struthers AD. Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients. Cardiovasc Res. 1997;35:30-34.
    • (1997) Cardiovasc Res. , vol.35 , pp. 30-34
    • MacFayden, R.J.1    Barr, C.S.2    Struthers, A.D.3
  • 6
    • 0032410815 scopus 로고    scopus 로고
    • Aldosterone blunts the baroreflex response in man
    • Yee KM, Struthers AD. Aldosterone blunts the baroreflex response in man. Clin Sci. 1998;95:687-692.
    • (1998) Clin Sci. , vol.95 , pp. 687-692
    • Yee, K.M.1    Struthers, A.D.2
  • 7
    • 0032169994 scopus 로고    scopus 로고
    • Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients
    • Duprez DA, DeBuyzere ML, Rietzschel ER, et al. Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients. Eur Heart J. 1998;19:1371-1376.
    • (1998) Eur. Heart J. , vol.19 , pp. 1371-1376
    • Duprez, D.A.1    DeBuyzere, M.L.2    Rietzschel, E.R.3
  • 8
    • 0028912882 scopus 로고
    • Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells: A potential link between the renin-angiotensin system and thrombosis
    • Vaughan DE, Lazos SA, Tong K. Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells: a potential link between the renin-angiotensin system and thrombosis. J Clin Invest. 1995;95:995-1001.
    • (1995) J. Clin. Invest. , vol.95 , pp. 995-1001
    • Vaughan, D.E.1    Lazos, S.A.2    Tong, K.3
  • 9
    • 0032588244 scopus 로고    scopus 로고
    • Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: Role in aldosterone-salt induced fibrosis
    • Robert V, Heymes C, Silvestre JS, et al. Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt induced fibrosis. Hypertension. 1999;33:981-986.
    • (1999) Hypertension , vol.33 , pp. 981-986
    • Robert, V.1    Heymes, C.2    Silvestre, J.S.3
  • 10
    • 0343554659 scopus 로고    scopus 로고
    • Monitoring fibrillar collagen turnover in hypertensive heart disease
    • Diez J, Laviades C. Monitoring fibrillar collagen turnover in hypertensive heart disease. Cardiovasc Res. 1997;35:202-205.
    • (1997) Cardiovasc. Res. , vol.35 , pp. 202-205
    • Diez, J.1    Laviades, C.2
  • 11
    • 0028097678 scopus 로고
    • QT dispersion and sudden unexpected death in chronic heart failure
    • Barr CS, Naas A, Freeman M, et al. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 1994;343:327-329.
    • (1994) Lancet , vol.343 , pp. 327-329
    • Barr, C.S.1    Naas, A.2    Freeman, M.3
  • 12
    • 0030096265 scopus 로고    scopus 로고
    • Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure
    • Struthers AD. Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure. J Card Fail. 1996;2:47-54.
    • (1996) J. Card. Fail. , vol.2 , pp. 47-54
    • Struthers, A.D.1
  • 13
    • 0035369667 scopus 로고    scopus 로고
    • Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD Genotype
    • Cicoira M, Zanolla L, Rossi A, et al. Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD Genotype. J Am Coll Cardiol. 2001;37:1808-1812.
    • (2001) J. Am. Coll. Cardiol. , vol.37 , pp. 1808-1812
    • Cicoira, M.1    Zanolla, L.2    Rossi, A.3
  • 14
    • 0028229413 scopus 로고
    • Cardiac renin and angiotensins: Uptake from plasma versus in situ synthesis
    • Danser AH, Van Kats JP, Admiraal PJ, et al. Cardiac renin and angiotensins: uptake from plasma versus in situ synthesis. Hypertension. 1994;24:37-48.
    • (1994) Hypertension , vol.24 , pp. 37-48
    • Danser, A.H.1    Van Kats, J.P.2    Admiraal, P.J.3
  • 15
    • 0035830440 scopus 로고    scopus 로고
    • Aldosterone production is activated in failing ventricle in humans
    • Mizuno Y, Yoshimura M, Yasue H, et al. Aldosterone production is activated in failing ventricle in humans. Circulation. 2001;103:72-77.
    • (2001) Circulation , vol.103 , pp. 72-77
    • Mizuno, Y.1    Yoshimura, M.2    Yasue, H.3
  • 16
    • 0034585311 scopus 로고    scopus 로고
    • Transforming growth factor-beta(1) induces angiotensin-converting enzyme synthesis in rat cardiac fibroblasts during their differentiation to myofibroblasts
    • Petrov VV, Fagard RH, Lijnen PJ. Transforming growth factor-beta(1) induces angiotensin-converting enzyme synthesis in rat cardiac fibroblasts during their differentiation to myofibroblasts. J Renin Angiotensin Aldosterone Syst. 2000;1:342-352.
    • (2000) J. Renin. Angiotensin Aldosterone Syst. , vol.1 , pp. 342-352
    • Petrov, V.V.1    Fagard, R.H.2    Lijnen, P.J.3
  • 17
    • 0032570807 scopus 로고    scopus 로고
    • Myocardial production of aldosterone and corticosterone in the rat: Physiological regulation
    • Silvestre JS, Robert V, Heymes C, et al. Myocardial production of aldosterone and corticosterone in the rat: physiological regulation. J Biol Chem. 1998;273:4883-4891.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4883-4891
    • Silvestre, J.S.1    Robert, V.2    Heymes, C.3
  • 18
    • 0027381252 scopus 로고
    • Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain
    • Mellon SH, Deschepper CF. Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 1993;629:283-292.
    • (1993) Brain Res. , vol.629 , pp. 283-292
    • Mellon, S.H.1    Deschepper, C.F.2
  • 19
    • 0027997406 scopus 로고
    • Vascular aldosterone: Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells
    • Hatakeyama H, Miyamori I, Fujita T, et al. Vascular aldosterone: biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem. 1994;269:24316-24320.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24316-24320
    • Hatakeyama, H.1    Miyamori, I.2    Fujita, T.3
  • 20
    • 0027529918 scopus 로고
    • Angiotensin-converting enzyme inhibition does not suppress plasma angiotensin II increase during exercise in humans
    • Aldigier JC, Huang H, Dalmay F, et al. Angiotensin-converting enzyme inhibition does not suppress plasma angiotensin II increase during exercise in humans. J Cardiovasc Pharmacol. 1993;21:289-295.
    • (1993) J. Cardiovasc. Pharmacol. , vol.21 , pp. 289-295
    • Aldigier, J.C.1    Huang, H.2    Dalmay, F.3
  • 21
    • 0029083297 scopus 로고
    • Angiotensin-converting enzyme in the human heart: Effect of the deletion/insertion polymorphism
    • Danser AH, Schalekamp MA, Bax WA, et al. Angiotensin-converting enzyme in the human heart: effect of the deletion/insertion polymorphism. Circulation. 1995;92:1387-1388.
    • (1995) Circulation , vol.92 , pp. 1387-1388
    • Danser, A.H.1    Schalekamp, M.A.2    Bax, W.A.3
  • 22
    • 0030198578 scopus 로고    scopus 로고
    • The DD genotype of the angiotensin-converting enzyme gene is associated with increased mortality in idiopathic heart failure
    • Anderson B, Sylven C. The DD genotype of the angiotensin-converting enzyme gene is associated with increased mortality in idiopathic heart failure. J Am Coll Cardiol. 1996;28:162-167.
    • (1996) J. Am. Coll. Cardiol. , vol.28 , pp. 162-167
    • Anderson, B.1    Sylven, C.2
  • 23
    • 0030901037 scopus 로고    scopus 로고
    • Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion
    • Okubo S, Niimura F, Nishimura H, et al. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. J Clin Invest. 1997;99:855-860.
    • (1997) J. Clin. Invest. , vol.99 , pp. 855-860
    • Okubo, S.1    Niimura, F.2    Nishimura, H.3
  • 24
    • 0027457072 scopus 로고
    • Aldosterone and antialdosterone therapy in congestive heart failure
    • Weber KT, Villarreal D. Aldosterone and antialdosterone therapy in congestive heart failure. Am J Cardiol. 1993;71:3A-11A.
    • (1993) Am. J. Cardiol. , vol.71
    • Weber, K.T.1    Villarreal, D.2
  • 25
    • 0031045937 scopus 로고    scopus 로고
    • Association between circulating components of the renin angiotensin aldosterone system and left ventricular mass
    • Schunkert H, Hense HW, Danser J, et al. Association between circulating components of the renin angiotensin aldosterone system and left ventricular mass. Br Heart J. 1997;77:24-31.
    • (1997) Br. Heart. J. , vol.77 , pp. 24-31
    • Schunkert, H.1    Hense, H.W.2    Danser, J.3
  • 26
    • 0030918425 scopus 로고    scopus 로고
    • Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states
    • Zennaro MC, Farman N, Bonbalet JP, Lombes M. Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states. J Clin Endocrinol Metab. 1997;82:1345-1352.
    • (1997) J. Clin. Endocrinol Metab. , vol.82 , pp. 1345-1352
    • Zennaro, M.C.1    Farman, N.2    Bonbalet, J.P.3    Lombes, M.4
  • 27
    • 0028275578 scopus 로고
    • Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone
    • Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol. 1994;26:809-820.
    • (1994) J. Mol. Cell. Cardiol. , vol.26 , pp. 809-820
    • Brilla, C.G.1    Zhou, G.2    Matsubara, L.3    Weber, K.T.4
  • 28
    • 0028840698 scopus 로고
    • Biochemical determinants of aldosterone-induced cardiac fibrosis in rats
    • Robert V, Silvestre JS, Charlemagne D, et al. Biochemical determinants of aldosterone-induced cardiac fibrosis in rats. Hypertension. 1995;26:971-978.
    • (1995) Hypertension , vol.26 , pp. 971-978
    • Robert, V.1    Silvestre, J.S.2    Charlemagne, D.3
  • 29
    • 0035818917 scopus 로고    scopus 로고
    • Aldosterone in congestive heart failure
    • Weber KT. Aldosterone in congestive heart failure. N Engl J Med. 2001;345:1689-1697.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1689-1697
    • Weber, K.T.1
  • 30
    • 0026692172 scopus 로고
    • Aldosterone regulation of gene transcription leading to control of ion transport
    • Horisberger JD, Rossier BC. Aldosterone regulation of gene transcription leading to control of ion transport. Hypertension. 1992;19:221-227.
    • (1992) Hypertension , vol.19 , pp. 221-227
    • Horisberger, J.D.1    Rossier, B.C.2
  • 31
    • 0028360454 scopus 로고
    • Increased cardiac type I and III collagen mRNA in aldosterone-salt hypertension
    • Robert V. Van Thiem N, Cheav SL, et al. Increased cardiac type I and III collagen mRNA in aldosterone-salt hypertension. Hypertension. 1994;24:30-36.
    • (1994) Hypertension , vol.24 , pp. 30-36
    • Robert, V.1    Van Thiem, N.2    Cheav, S.L.3
  • 32
    • 0037180412 scopus 로고    scopus 로고
    • Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: Effects of eplerenone
    • Lacolley P, Labat C, Pujol A, et al. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone. Circulation. 2002;106:2848-2853.
    • (2002) Circulation , vol.106 , pp. 2848-2853
    • Lacolley, P.1    Labat, C.2    Pujol, A.3
  • 33
    • 0028786493 scopus 로고
    • The aminoterminal propeptide of type III procollagen provides new information on prognosis after acute myocardial infarction
    • Host NB, Jensen LT, Bendixen PM, et al. The aminoterminal propeptide of type III procollagen provides new information on prognosis after acute myocardial infarction. Am J Cardiol. 1995;76:869-873.
    • (1995) Am. J. Cardiol. , vol.76 , pp. 869-873
    • Host, N.B.1    Jensen, L.T.2    Bendixen, P.M.3
  • 34
    • 0024410697 scopus 로고
    • Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle
    • Jalil JE, Doering CW, Janicki JS, et al. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res. 1989;64:1041-1050.
    • (1989) Circ. Res. , vol.64 , pp. 1041-1050
    • Jalil, J.E.1    Doering, C.W.2    Janicki, J.S.3
  • 35
    • 0023882927 scopus 로고
    • Microvascular changes in the heart during chronic arterial hypertension
    • Laine GA. Microvascular changes in the heart during chronic arterial hypertension. Circ Res. 1988;62:953-960.
    • (1988) Circ Res. , vol.62 , pp. 953-960
    • Laine, G.A.1
  • 36
    • 0028202098 scopus 로고
    • Colocalization of myocardial fibrosis and inflammatory cells in rats
    • Hinglais N, Heudes D, Nicoletti A, et al. Colocalization of myocardial fibrosis and inflammatory cells in rats. Lab Invest. 1994;70:286-294.
    • (1994) Lab. Invest. , vol.70 , pp. 286-294
    • Hinglais, N.1    Heudes, D.2    Nicoletti, A.3
  • 37
    • 0036182871 scopus 로고    scopus 로고
    • Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts
    • Petrov VV, Fagard RH, Lijnen PJ. Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension. 2002;39:258-263.
    • (2002) Hypertension , vol.39 , pp. 258-263
    • Petrov, V.V.1    Fagard, R.H.2    Lijnen, P.J.3
  • 38
    • 0030249501 scopus 로고    scopus 로고
    • Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-beta1
    • Sigel AV, Centrella M, Eghbali-Webb M. Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-beta1. J Mol Cell Cardiol. 1996;28:1921-1929.
    • (1996) J. Mol. Cell. Cardiol. , vol.28 , pp. 1921-1929
    • Sigel, A.V.1    Centrella, M.2    Eghbali-Webb, M.3
  • 39
    • 0000685149 scopus 로고    scopus 로고
    • Aldosterone regulates collagen output of rat cardiac fibroblasts by up-regulation of endothelin receptors
    • Fullerton MJ, Funder JW. Aldosterone regulates collagen output of rat cardiac fibroblasts by up-regulation of endothelin receptors. Endocrinol Soc Proc. 1998;93:511.
    • (1998) Endocrinol. Soc. Proc. , vol.93 , pp. 511
    • Fullerton, M.J.1    Funder, J.W.2
  • 40
    • 0030587794 scopus 로고    scopus 로고
    • Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure
    • The RALES Investigators. (the Randomized Aldactone Evaluation Study [RALES])
    • The RALES Investigators. Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study [RALES]). Am J Cardiol. 1996;78:902-907.
    • (1996) Am. J. Cardiol. , vol.78 , pp. 902-907
  • 41
    • 0000729469 scopus 로고    scopus 로고
    • Diuretics
    • Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. 9th ed. New York, NY: McGraw-Hill Book Co
    • Jackson EK. Diuretics. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill Book Co; 1996:706-711.
    • (1996) Goodman & Gilman's The Pharmacological Basis of Therapeutics , pp. 706-711
    • Jackson, E.K.1
  • 42
    • 0007990613 scopus 로고
    • The effects of a mineralocorticoid antagonist on myocardial MIBG uptake in congestive heart failure
    • Barr CS, Hanson J, Kennedy N, et al. The effects of a mineralocorticoid antagonist on myocardial MIBG uptake in congestive heart failure. Circulation. 1993;88:I256.
    • (1993) Circulation , vol.88
    • Barr, C.S.1    Hanson, J.2    Kennedy, N.3
  • 43
    • 0037116558 scopus 로고    scopus 로고
    • Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction: Role of vascular superoxide anion formation and endothelial nitric oxide synthase expression
    • Bauersachs J, Heck M, Fraccarollo D, et al. Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction: role of vascular superoxide anion formation and endothelial nitric oxide synthase expression. J Am Coll Cardiol. 2002;39:351-358.
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 351-358
    • Bauersachs, J.1    Heck, M.2    Fraccarollo, D.3
  • 44
    • 0027499223 scopus 로고
    • Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension
    • Brilla CG, Matsubara LS, Weber KT. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension. Am J Cardiol. 1993;71:12A-16A.
    • (1993) Am. J. Cardiol. , vol.71
    • Brilla, C.G.1    Matsubara, L.S.2    Weber, K.T.3
  • 45
    • 0027227646 scopus 로고
    • Anti-aldosterone treatment and prevention of myocardial fibrosis in primary and secondary hyperaldosteronism
    • Brilla CG, Matsubara LS, Weber KT Anti-aldosterone treatment and prevention of myocardial fibrosis in primary and secondary hyperaldosteronism. J Mol Cell Cardiol. 1993;25:563-575.
    • (1993) J. Mol. Cell. Cardiol. , vol.25 , pp. 563-575
    • Brilla, C.G.1    Matsubara, L.S.2    Weber, K.T.3
  • 46
    • 0035131479 scopus 로고    scopus 로고
    • Prevention of aortic and cardiac fibrosis by sphonolactone in old normotensive rats
    • Lacolley F, Safar ME, Lucet B, et al. Prevention of aortic and cardiac fibrosis by sphonolactone in old normotensive rats. J Am Coll Cardiol. 2001;37:662-667.
    • (2001) J. Am. Coll. Cardiol. , vol.37 , pp. 662-667
    • Lacolley, F.1    Safar, M.E.2    Lucet, B.3
  • 47
    • 0028890773 scopus 로고
    • Neointimal thickening after balloon denudation is enhanced by aldosterone and inhibited by spironolactone, and aldosterone antagonist
    • Van Belle E, Banters C, Wernert N, et al. Neointimal thickening after balloon denudation is enhanced by aldosterone and inhibited by spironolactone, and aldosterone antagonist. Cardiovasc Res. 1995;29:27-32.
    • (1995) Cardiovasc Res. , vol.29 , pp. 27-32
    • Van Belle, E.1    Banters, C.2    Wernert, N.3
  • 48
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure
    • For the Rales investigators
    • Zannad F, Alla F, Dousset B, et al, for the Rales investigators. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure. Circulation. 2000;102:2700-2706.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3
  • 49
    • 0034636189 scopus 로고    scopus 로고
    • Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease
    • Querejeta R, Varo N, Lopez B, et al. Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease. Circulation. 2000;101:1729-1735.
    • (2000) Circulation , vol.101 , pp. 1729-1735
    • Querejeta, R.1    Varo, N.2    Lopez, B.3
  • 50
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators
    • The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293-302.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 293-302
  • 51
    • 0027513313 scopus 로고
    • Captopril and spironolactone therapy for refractory congestive heart failure
    • Dahlstrom U, Karlsson E. Captopril and spironolactone therapy for refractory congestive heart failure. Am J Cardiol. 1993;71:29A-33A.
    • (1993) Am. J. Cardiol , vol.71
    • Dahlstrom, U.1    Karlsson, E.2
  • 53
    • 0035370038 scopus 로고    scopus 로고
    • Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure
    • Yee K-M, Pringle SD, Struthers AD. Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure. J Am Coll Cardiol. 2001;37:1800-1807.
    • (2001) J. Am Coll. Cardiol. , vol.37 , pp. 1800-1807
    • Yee, K.-M.1    Pringle, S.D.2    Struthers, A.D.3
  • 54
    • 17544392987 scopus 로고    scopus 로고
    • Effects of spironolactone on heart rate variability and left ventricular systolic function in severe ischemic heart failure
    • Korkmaz ME, Muderrisoglu H, Ulucam M, Ozin B. Effects of spironolactone on heart rate variability and left ventricular systolic function in severe ischemic heart failure. Am J Cardiol. 2000;86:649-653.
    • (2000) Am. J. Cardiol. , vol.86 , pp. 649-653
    • Korkmaz, M.E.1    Muderrisoglu, H.2    Ulucam, M.3    Ozin, B.4
  • 55
    • 0034332845 scopus 로고    scopus 로고
    • High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure
    • Maeda K, Tsutamoto T, Wada A, et al. High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure. J Am Coll Cardiol. 2000;36:1587-1593.
    • (2000) J. Am. Coll. Cardiol. , vol.36 , pp. 1587-1593
    • Maeda, K.1    Tsutamoto, T.2    Wada, A.3
  • 56
    • 0037032257 scopus 로고    scopus 로고
    • Beneficial neurohormonal profile of spironolactone in severe congestive heart failure
    • For the Belgian RALES investigators
    • Rousseau MF, Gurne O, Duprez D, et al, for the Belgian RALES investigators. Beneficial neurohormonal profile of spironolactone in severe congestive heart failure. J Am Coll Cardiol. 2002;40:1596-1601.
    • (2002) J. Am. Coll. Cardiol. , vol.40 , pp. 1596-1601
    • Rousseau, M.F.1    Gurne, O.2    Duprez, D.3
  • 57
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • For the Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, et al, for the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709-717.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 58
    • 0030049090 scopus 로고    scopus 로고
    • Early reduction of neurohormonal factors plays a key role in mediating the efficiency of beta-blocker therapy for congestive heart failure
    • Yoshikawa T, Handa S, Anzai T, et al. Early reduction of neurohormonal factors plays a key role in mediating the efficiency of beta-blocker therapy for congestive heart failure. Am Heart J. 1996;131:329-336.
    • (1996) Am. Heart. J. , vol.131 , pp. 329-336
    • Yoshikawa, T.1    Handa, S.2    Anzai, T.3
  • 59
    • 0035957262 scopus 로고    scopus 로고
    • Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    • McNamara DM, Holubkov R, Janosko K, et al. Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. Circulation. 2001;103:1644-1648.
    • (2001) Circulation , vol.103 , pp. 1644-1648
    • McNamara, D.M.1    Holubkov, R.2    Janosko, K.3
  • 60
    • 0035870772 scopus 로고    scopus 로고
    • Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: An analysis of 25 cases
    • Schepkens H, Vanholder R, Billouw JM, Lameire N. Life-threatening hyperkalemia during combined therapy with angiotensin-converting enzyme inhibitors and spironolactone: an analysis of 25 cases. Am J Med. 2001;110:438-441.
    • (2001) Am. J. Med. , vol.110 , pp. 438-441
    • Schepkens, H.1    Vanholder, R.2    Billouw, J.M.3    Lameire, N.4
  • 61
    • 0030799686 scopus 로고    scopus 로고
    • Hyperkalemia in the elderly: Drugs exacerbate impaired potassium homeostasis
    • Perazella MA, Mahnensmith RL. Hyperkalemia in the elderly: drugs exacerbate impaired potassium homeostasis. J Gen Intern Med. 1997;12:646-656.
    • (1997) J. Gen. Intern. Med. , vol.12 , pp. 646-656
    • Perazella, M.A.1    Mahnensmith, R.L.2
  • 62
    • 3042576308 scopus 로고    scopus 로고
    • The authors reply
    • For The Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Perez A, for The Randomized Aldactone Evaluation Study Investigators. The authors reply. N Engl J Med. 2000;342:133-134.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 133-134
    • Pitt, B.1    Perez, A.2
  • 63
    • 0016687047 scopus 로고
    • Antiandrogenic effects of spironolactones: Mechanism of action
    • Corvol P, Michaud A, Menard J, et al. Antiandrogenic effects of spironolactones: mechanism of action. Endocrinology. 1975;97:52-58.
    • (1975) Endocrinology , vol.97 , pp. 52-58
    • Corvol, P.1    Michaud, A.2    Menard, J.3
  • 64
    • 0036786124 scopus 로고    scopus 로고
    • Eplerenone: A novel selective aldosterone blocker
    • Zillich AJ, Carter BL. Eplerenone: a novel selective aldosterone blocker. Ann Pharmacother. 2002;36:1567-1576.
    • (2002) Ann. Pharmacother. , vol.36 , pp. 1567-1576
    • Zillich, A.J.1    Carter, B.L.2
  • 65
    • 0003100633 scopus 로고    scopus 로고
    • Effects of the selective mineralocorticoid receptor antagonist, eplerenone, in a model of aldosterone-induced hypertension and cardiac fibrosis
    • Frierdich G, Schuh J, Brown M, et al. Effects of the selective mineralocorticoid receptor antagonist, eplerenone, in a model of aldosterone-induced hypertension and cardiac fibrosis. Am J Hypertens. 1998;11:94A.
    • (1998) Am. J. Hypertens. , vol.11
    • Frierdich, G.1    Schuh, J.2    Brown, M.3
  • 66
    • 0037016007 scopus 로고    scopus 로고
    • Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure
    • Suzuki G, Morita H, Mishima T, et al. Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure. Circulation. 2002;106:2967-2972.
    • (2002) Circulation , vol.106 , pp. 2967-2972
    • Suzuki, G.1    Morita, H.2    Mishima, T.3
  • 67
    • 0001450875 scopus 로고    scopus 로고
    • Eplerenone, a novel selective aldosterone receptor antagonist (SARA): Dose-finding study in patients with heart failure
    • Pitt B, Roniker B. Eplerenone, a novel selective aldosterone receptor antagonist (SARA): dose-finding study in patients with heart failure. J Am Coll Cardiol. 1999;33:S188A-S189A.
    • (1999) J. Am. Coll. Cardiol. , vol.33
    • Pitt, B.1    Roniker, B.2
  • 68
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • For the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators
    • Pitt B, Remme W, Zannad F, et al, for the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309-1321.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 69
    • 0033592418 scopus 로고    scopus 로고
    • Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction
    • Cooper HA, Dries DL, Davis CE, et al. Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction. Circulation. 1999;100:1311-1315.
    • (1999) Circulation , vol.100 , pp. 1311-1315
    • Cooper, H.A.1    Dries, D.L.2    Davis, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.