Genotoxicity and mutagenicity of melanoidins isolated from a roasted glucose-glycine model in human lymphocyte cultures, intestinal Caco-2 cells and in the Salmonella typhimurium strains TA98 and TA102 applying the AMES test

Food and Chemical Toxicology

Volumn 42, Issue 9, 2004, Pages 1487-1495

  Glösl, Sigrid ^a   Wagner, Karl Heinz ^a   Draxler, Astrid ^a   Kaniak, Marianne ^a   Lichtenecker, Sandra ^a   Sonnleitner, Astrid ^a   Somoza, Veronika ^b   Erbersdobler, Helmut ^c   Elmadfa, Ibrahim ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

AMES test; BrdU, 5 bromo 2 deoxyuridine; Caco 2 cells; DMEM, Dulbecco's Modified Eagle's Medium; Glucose glycine; HMW, water soluble high molecular weight fraction; Human lymphocyte cultures; Maillard reaction; Oxidative stress; Sister chromatid exchange

Indexed keywords

GLUCOSE; GLYCINE; MELANOIDIN DERIVATIVE; MUTAGENIC AGENT; UNCLASSIFIED DRUG;

ADULT; AMES TEST; ARTICLE; BACTERIAL STRAIN; CELL PROLIFERATION; CELL STRAIN CACO 2; CELL VIABILITY; CONTROLLED STUDY; COOKING; GENOTOXICITY; HUMAN; HUMAN CELL; INTESTINE CELL; LYMPHOCYTE CULTURE; MALE; MODEL; MOLECULAR WEIGHT; MUTAGENICITY; SALMONELLA TYPHIMURIUM; SISTER CHROMATID EXCHANGE;

ADULT; CACO-2 CELLS; CELL DIVISION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLYCINE; HUMANS; INTESTINE, SMALL; LYMPHOCYTES; MAILLARD REACTION; MALE; MUTAGENICITY TESTS; MUTAGENS; POLYMERS; SALMONELLA TYPHIMURIUM; SISTER CHROMATID EXCHANGE;

CICONIIFORMES; SALMONELLA TYPHIMURIUM;

EID: 3042609733     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2004.04.011     Document Type: Article

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