Use of natural plant exudates (Sanguis Draxonis) for sustained oral insulin delivery with dramatic reduction of glycemic effects in diabetic rats

Journal of Controlled Release

Volumn 97, Issue 3, 2004, Pages 467-475

  Zhenqing, Hou ^a   Zhenxi, Zhang ^a   Chuanxin, Zhang ^b   Mei, Huang ^c  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b XinTai People Hospital   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Drug delivery; Hypoglycemic; Nanocapsules; Oral; Sanguis Draxonis

Indexed keywords

DISEASE CONTROL; ENZYMES; INSULIN; ISOTOPES; PLANTS (BOTANY); SOLUTIONS;

INSULIN DELIVERY; ORAL ADMINISTRATION;

DRUG PRODUCTS;

GLUCOSE; INSULIN; IODINE 125; PLANT EXTRACT; PROTEINASE; SANGUIS DRAXONIS EXTRACT; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE TIME EFFECT RELATION; DRUG CAPSULE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; ENCAPSULATION; GLUCOSE BLOOD LEVEL; HEART; IN VITRO STUDY; INCUBATION TIME; ISOTOPE LABELING; KIDNEY; LIVER; LUNG; MALE; MODEL; NONHUMAN; ORGAN; PLANT; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SANGUIS DRAXONIS; SPLEEN; STORAGE TEMPERATURE; STREPTOZOCIN DIABETES; SUSTAINED DRUG RELEASE; TECHNIQUE; TEMPERATURE;

ADMINISTRATION, ORAL; ANIMALS; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DRACAENA; DRUGS, CHINESE HERBAL; GLYCEMIC INDEX; INSULIN; MALE; RATS; RATS, WISTAR;

EID: 3042602444     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.03.033     Document Type: Article

References (25)

1. Garino G.P., Mathiowitz E. Oral insulin delivery. Adv. Drug Deliv. Rev. 35:1999;249-257
2. Iwanaga K., Ono S., Narioka K., Morimoto K., Kakemi M., Yumashita S., Nanqo M., Oku N. Oral delivery of insulin by using surface coating liposomes. Improvement of stability of insulin in GI tract. Int. J. Pharm. 157:1997;73-80
3. Damgé C., Michel C., Aprahamian M., Couverur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes. 37:1988;246-251
4. Marschutz M.K., Caliceti P., Bernkop-Schnorch A. Design and in vivo evaluation of an oral delivery system for insulin. Pharm. Res. 17:2000;1468-1474
5. L. Bay, N.F. Wang, Modified amino acids for drug delivery, U.S. Patent 6180140 (2001).
6. Levien T.L., Baker D.E. Reviews of levomethadyl acetate and degradable starch microspheres. Hosp. Pharm. 28:1993;1214-1222
7. Feng P., Wang Y., Ma J.B., He B.L. Study on materials of oral delivery system for peptides and its controlled-release: controlled release of insulin from its Chitosan-Alginate microcapsule. Ion Exch. Adsorpt. 15:1999;64-70
8. Musabayane C.T., Munjeri O., Bwititi P., Osim E.E. Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin-diabetic rats. J. Endocrinol. 164:2000;1-6
9. Dorkoosh F.A., Verhoef J.C., Borchard G., Rafiee-Tehrani M., Verheijden J.H.M., Junginger H.E. Intestinal absorption of human insulin in pigs using delivery systems based on superporous hydrogel polymers. Int. J. Pharm. 247:2002;47-55
10. Mitsuko T., Yoko Y., Aki K., Yasuaki O., Yutaka M., Rie I. A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release. J. Control. Release. 79:2002;81-91
11. Gerardo P., Carino J.S., Jacob E.M. Nanosphere based oral insulin delivery. J. Control. Release. 65:2000;261-269
12. Touitou E., Rubinstein A. Targeted enteral delivery of insulin to rats. Int. J. Pharm. 30:1986;95-99
13. 2EDTA and sodium glycocholate on the intestinal absorption of insulin. Biol. Pharm. Bull. 16:1993;68-72
14. Saffran M., Suhesh G., Savariar C., Burnham J.C., Williams F., Nekers D.C. A new approach to the oral administration of insulin and other peptide drugs. Science. 233:1987;1081-1084
15. Zhou Z.H., Wang J.L., Yang C.R. Chemical constituents of Sanguis Draxonis made in China. Chin. Tradit. Herb. Drugs. 32:2001;484-486. (in Chinese)
16. Zhong L., Mi H.M. Review of pharmacological effects of the Sanguis Draxonis. J. Pharm. Pract. 20:2002;332-334. (in Chinese)
17. Wen D.X. Advances in studies on resin of Dracaena cochinchinensis. Chin. Tradit. Herb. Drugs. 32:2001;1053-1054. (in Chinese)
18. Zhang R.X., Wang J.R., Wu C.F., Jia Z.P., Kong L.Y. Effects of resina draconis on the levels of blood glucose, insulin and lipids in rats. Tradit. Chin. Drug Res. Clin. Pharm. 13:2002;23-26. (in Chinese)
19. Wang S.L., Su D.S., Gu X.Q., Zhang J.H. Release characteristics, absolute bioavailability and distribution of the Insulin microparticles (INS-MP) in mice. J. Shenyang Pharm. Univ. 17:2000;79-83. (in Chinese)
20. Damgé C., Vranckx H., Balschmidt P., Couvreur P. Poly (alkylcyanoacrylate) nanospheres for oral administration of insulin. J. Pharm. Sci. 86:1997;1403-1409
21. Zhang Q., Shen Z., Nagai T. Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanocapsules after pulmonary administration to normal rats. Int. J. Pharm. 218:2001;75-80
22. Chien Y.W. Human insulin: basic sciences to therapeutic uses. Drug Dev. Ind. Pharm. 22:1996;753-789
23. Aprahamian M., Damgé C., Michel C. Transmucosal passage of polyalkylcyanoacylate nanocapsules as a new drug carrier in the small intestine. Biol. Cell. 61:1987;69-76
24. Pappo J., Ermark T.H. Uptake and translocation of fluorescent latex particles by rabbit Peyer's Patch follicle epithelium: a quantitative model for M cell uptake. Clin. Exp. Immunol. 76:1989;144-148
25. Ermark T.H., Dougherty E.P., Bhagat H.R., Kabok Z., Pappo J. Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells. Cell Tissue Res. 279:1995;433-436