Intestinal absorption of human insulin in pigs using delivery systems based on superporous hydrogel polymers

International Journal of Pharmaceutics

Volumn 247, Issue 1-2, 2002, Pages 47-55

  Dorkoosh, F A ^a   Verhoef, J C ^a   Borchard, G ^a   Rafiee Tehrani, M ^a   Verheijden, J H M ^b   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Insulin; Intestinal peptide absorption; Pigs; SPH composite (SPHC); Superporous hydrogels (SPH)

Indexed keywords

GELATIN; GLUCOSE; INSULIN; PEPTIDE; POLYMER; SILICONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CANNULA; CARBOHYDRATE ANALYSIS; COMPOSITE MATERIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DUODENUM; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH STATUS; HYDROGEL; IN VIVO STUDY; INTESTINE ABSORPTION; JUGULAR VEIN; NONHUMAN; POROSITY; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYDROGELS; INSULIN; INTESTINAL ABSORPTION; POLYMERS; POROSITY; SWINE;

EID: 0037168238     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00361-7     Document Type: Article

References (26)

1. Aboubakar M., Couvreur P., Pinto-Alphandary H., Gouritin B., Lacour B., Farinotti R., Puisieux F., Vauthier C. Insulin-loaded nanocapsules for oral administration: in vitro and in vivo investigation. Drug Dev. Res. 49:2000;109-117.
2. Chen J., Park K. Synthesis and characterization of superporous hydrogel composites. J. Control. Rel. 65:2000;73-82.
3. Choudhari K.B., Labhasetwar V., Dorle A.K. Liposomes as a carrier for oral administration of insulin: effect of formulation factors. J. Microencap. 11:1994;319-325.
4. Couvreur P., Lenaerts V., Kante B., Roland M., Speiser P.P. Oral and parenteral administration of insulin associated to hydrolysable nanoparticles. Acta Pharm. Technol. 26:1980;220-222.
5. Damgé C., Michel C., Aprahamian M., Couvreur P., Devissaguet J.P. Nanocapsules as carriers for oral peptide delivery. J. Control. Rel. 13:1990;233-239.
6. Dorkoosh F.A., Brussee J., Verhoef J.C., Borchard G., Rafiee-Tehrani M., Junginger H.E. Preparation and NMR characterisation of superporous hydrogels (SPH) and SPH composites. Polymer. 41:2000;8213-8220.
7. Dorkoosh F.A., Verhoef J.C., Borchard G., Rafiee-Tehrani M., Junginger H.E. Development and characterization of a novel peroral peptide drug delivery system. J. Control. Rel. 71:2001;307-318.
8. Dorkoosh F.A., Borchard G., Rafiee-Tehrani M., Verhoef J.C., Junginger H.E. Evaluation of superporous hydrogel (SPH) and SPH composite in porcine intestine ex vivo: assessment of drug transport, morphology effect, and mechanical fixation to intestinal wall. Eur. J. Pharm. Biopharm. 53:2002;161-166.
9. Dorkoosh F.A., Verhoef J.C., Ambagts M.H.C., Rafiee-Tehrani M., Borchard G., Junginger H.E. Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin, octreotide and insulin. Eur. J. Pharm. Sci. 15:2002;433-439.
10. Dorkoosh, F.A., Setyaningsih, D., Borchard, G., Rafiee-Tehrani, M., Verhoef, J.C., Junginger, H.E., 2002c. Effects of superporous hydrogels on paracellular drug permeability and cytotoxicity studies in Caco-2 cell monolayers. Int. J. Pharm. 241, 35-45.
11. Dorkoosh, F.A., Verhoef, J.C., Rafiee-Tehrani, M., Verheijden, J.H.M., Borchard, G., Junginger, H.E., 2002d. Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers. Pharm. Res. 19, 1530-1534.
12. Fix J.A. Oral controlled release technology for peptides: status and future prospects. Pharm. Res. 13:1996;1760-1764.
13. Gibaldi M., Perrier D. Pharmacokinetics. Swarbrick J., Drugs and the Pharmaceutical Sciences. 1975;409-424 Marcel Dekker, New York.
14. Havel P.J., Taborsky G.J. The contribution of the autonomic nervous system to changes of glucagon and insulin secretion during hypoglycemic stress. Endocr. Rev. 10:1989;332-350.
15. Hosny E.A., Ghilzai N.M.K., Elmazar M.M. Promotion of oral insulin absorption in diabetic rabbits using pH-dependent coated capsules containing sodium cholate. Pharm. Acta Helv. 72:1997;203-207.
16. Houtzagers C.M.G.J., Berntzen P.A., Stap H., Heine R.J., Veen E.A. Absorption kinetics of short- and intermediate-acting insulins after jet injection with Medijector II. Diabetes Care. 11:1988;739-742.
17. Irsigler K., Kritz H., Hagmüller G., Franetzki M., Prestele K., Thurow H., Geisen K. Long-term continuous intraperitoneal insulin infusion with an implanted remote-controlled insulin infusion device. Diabetes. 30:1981;1072-1075.
18. Johnson T.J., Quigley E.M.M., Adrian T.E., Jin G.L., Rikkers L.F. Glucagon, stress, and portal hypertension: plasma glucagon levels and portal hypertension in relation to anesthesia and surgical stress. Dig. Dis. Sci. 40:1995;1816-1823.
19. Kisel M.A., Kulik L.N., Tsybovsky I.S., Vlasov A.P., Vorob'yov M.S., Kholodova E.A., Zabarovskaya Z.V. Liposomes with phophatidylethanol as a carrier for oral delivery of insulin: studies in the rat. Int. J. Pharm. 216:2001;105-114.
20. Michael S., Thöle M., Dillmann R., Fahr A., Drewe J., Fricker G. Improvement of intestinal peptide absorption by synthetic bile acid derivative, cholylsarcosine. Eur. J. Pharm. Sci. 10:2000;133-140.
21. Saffran M., Pansky B., Budd G.C., Williams F.E. Insulin and the gastrointestinal tract. J. Control. Rel. 46:1997;89-98.
22. Thanou M., Verhoef J.C., Verheijden J.H.M., Junginger H.E. Intestinal absorption of octreotide using trimethyl chitosan chloride: studies in pigs. Pharm. Res. 18:2001;823-828.
23. Tozaki H., Komoike J., Tada C., Maruyama T., Terabe A., Suzuki T., Yamamoto A., Muranishi S. Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. J. Pharm. Sci. 86:1997;1016-1021.
24. Tozaki H., Nishioka J., Komoike J., Okada N., Fujita T., Muranishi S., Kim S.I., Terashima H., Yamamoto A. Enhanced absorption of insulin and (Asu(1,7))eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery. J. Pharm. Sci. 90:2001;89-97.
25. Walters D.P., Smith P.A., Marteau T.M., Brimble A., Borthwick L.J. Experience with NovoPen, an injection device using cartridged insulin, for diabetic patients. Diabetic Med. 2:1985;496-497.
26. Ziv E., Kidron M., Raz I., Krausz M., Blatt Y., Rotman A., Bar-On H. Oral administration of insulin in solid form to nondiabetic and diabetic dogs. J. Pharm. Sci. 83:1994;792-794.