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Volumn 44, Issue 20, 2001, Pages 3223-3230

Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: A comparative molecular field analysis

(5) Chavatte, P a Yous, S a Marot, C b Baurin, N b Lesieur, D a

a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille (France)

b UNIVERSITÉ D'ORLÉANS (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ANTIINFLAMMATORY AGENT; BENZENE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; CYCLOPENTENE DERIVATIVE; IMIDAZOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PYRAZOLE DERIVATIVE; PYRROLE DERIVATIVE; SPIROHEPTADIENE DERIVATIVE; SPIROHEPTENE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME STRUCTURE; INFLAMMATION; LIPOPHILICITY; QUANTITATIVE ASSAY; STRUCTURE ACTIVITY RELATION;

BENZENE DERIVATIVES; BINDING SITES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYCLOPENTANES; IMIDAZOLES; ISOENZYMES; ISOXAZOLES; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPIRO COMPOUNDS; THIOPHENES;

EID: 0035960062 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm0101343 Document Type: Article

Times cited : (118)

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