Three-dimensional quantitative structural activity relationship (3D-QSAR) studies of some 1,5-diarylpyrazoles: Analogue based design of selective cyclooxygenase-2 inhibitors

Molecules

Volumn 5, Issue 7, 2000, Pages 945-955

  Desiraju, Gautam R ^a   Gopalakrishnan, Bulusu ^b   Jetti, Ram K R ^a   Raveendra, Dayam ^c   Sarma, Jagarlapudi A R P ^c   Subramanya, Hosahalli S ^d  

^a UNIVERSITY OF HYDERABAD   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^d CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

3D QSAR; CoMFA; MFA; NSAID design; RSA; Selective COX 2 inhibitors

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; PYRAZOLE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG ACTIVITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; GENETIC ALGORITHM; MODEL; MOLECULAR FIELD ANALYSIS; PARTIAL LEAST SQUARE FIT; PREDICTION; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR SURFACE ANALYSIS; STRUCTURE ANALYSIS; VALIDATION PROCESS;

EID: 0000091651     PISSN: 14203049     EISSN: None     Source Type: Journal    
DOI: 10.3390/50700945     Document Type: Article

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