Privileged scaffolds for blocking protein-protein interactions: 1,4-Disubstituted naphthalene antagonists of transcription factor complex HOX-PBX/DNA

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 15, 2004, Pages 3875-3879

  Ji, Tao ^a   Lee, Madison ^b   Pruitt, Steven C ^b   Hangauer, David G ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

BRN; HOX; PBX; Protein protein interaction antagonists; Transcription factor complex antagonists

Indexed keywords

DNA; NAPHTHALENE DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXB1; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG SYNTHESIS; DRUG TARGETING; INHIBITION KINETICS; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

CRYSTALLOGRAPHY, X-RAY; DNA; DNA-BINDING PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; KINETICS; MODELS, MOLECULAR; NAPHTHALENES; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 3042598803     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.068     Document Type: Article

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