메뉴 건너뛰기




Volumn 36, Issue 7, 2000, Pages 925-931

Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair proteins hMSH2 and hMLH1

Author keywords

hMLH1; hMSH2; Human gastric carcinoma cell lines; Microsatellite instability; MNNG tolerance

Indexed keywords

ALKYLATING AGENT; METHYLNITRONITROSOGUANIDINE; PROTEIN;

EID: 0034095091     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00025-3     Document Type: Article
Times cited : (29)

References (39)
  • 1
    • 0027742295 scopus 로고
    • The human mutator gene homologue MSH2 and its association with hereditary nonpolyposis colon cancer
    • Fishel R., Lescoe M.K., Rao M.R.et al. The human mutator gene homologue MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 75:1993;1027-1038.
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.3
  • 2
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer
    • Bronner C.E., Baker S.M., Morrison P.T.et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer. Nature. 368:1994;258-261.
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3
  • 3
    • 9544241423 scopus 로고    scopus 로고
    • Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer
    • Han H.-J., Yuan Y., Ku J.-L.et al. Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer. J. Natl. Cancer Inst. 88:1996;1317-1319.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1317-1319
    • Han, H.-J.1    Yuan, Y.2    Ku, J.-L.3
  • 4
    • 0027933070 scopus 로고
    • Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
    • Nicolaides N.C., Papadopoulos N., Liu B.et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature. 371:1994;75-80.
    • (1994) Nature , vol.371 , pp. 75-80
    • Nicolaides, N.C.1    Papadopoulos, N.2    Liu, B.3
  • 5
    • 0030870631 scopus 로고    scopus 로고
    • Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred
    • Akiyama Y., Sato H., Yamada T.et al. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res. 57:1997;3920-3923.
    • (1997) Cancer Res. , vol.57 , pp. 3920-3923
    • Akiyama, Y.1    Sato, H.2    Yamada, T.3
  • 6
    • 0032942361 scopus 로고    scopus 로고
    • Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer
    • Shin K.-H., Ku J.-L., Park J.-G. Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. J. Hum. Genet. 44:1999;18-21.
    • (1999) J. Hum. Genet. , vol.44 , pp. 18-21
    • Shin, K.-H.1    Ku, J.-L.2    Park, J.-G.3
  • 7
    • 0030739106 scopus 로고    scopus 로고
    • Molecular basis of HNPCC: Mutations of MMR genes
    • Papadopoulos N., Lindblom A. Molecular basis of HNPCC. mutations of MMR genes Hum. Mutat. 10:1997;89-99.
    • (1997) Hum. Mutat. , vol.10 , pp. 89-99
    • Papadopoulos, N.1    Lindblom, A.2
  • 8
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • Modrich P., Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65:1996;101-133.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 9
    • 0028867842 scopus 로고
    • Mismatch repair: Mechanisms and relationship to cancer susceptibility
    • Kolodner R.D. Mismatch repair. mechanisms and relationship to cancer susceptibility Trends Biochem. Sci. 20:1995;397-401.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 397-401
    • Kolodner, R.D.1
  • 10
    • 0028785603 scopus 로고
    • Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer
    • Parsons R., Myeroff L., Liu B.et al. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res. 55:1995;5548-5550.
    • (1995) Cancer Res. , vol.55 , pp. 5548-5550
    • Parsons, R.1    Myeroff, L.2    Liu, B.3
  • 11
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N., Yamamoto H., Ionov Y.et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science. 275:1997;967-969.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3
  • 12
    • 14444287748 scopus 로고    scopus 로고
    • The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum
    • Ouyang H., Shiwaku H.O., Hagiwara H.et al. The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum. Cancer Res. 57:1997;1851-1854.
    • (1997) Cancer Res. , vol.57 , pp. 1851-1854
    • Ouyang, H.1    Shiwaku, H.O.2    Hagiwara, H.3
  • 13
    • 0029783835 scopus 로고    scopus 로고
    • Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair
    • Risinger J.I., Umar A., Boyd J., Berchuck A., Kunkel T.A., Barrett J.C. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nature Genet. 14:1996;102-105.
    • (1996) Nature Genet. , vol.14 , pp. 102-105
    • Risinger, J.I.1    Umar, A.2    Boyd, J.3    Berchuck, A.4    Kunkel, T.A.5    Barrett, J.C.6
  • 14
    • 16944361874 scopus 로고    scopus 로고
    • Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas
    • Yin J., Kong D., Wang S.et al. Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. Hum. Mutat. 10:1997;474-478.
    • (1997) Hum. Mutat. , vol.10 , pp. 474-478
    • Yin, J.1    Kong, D.2    Wang, S.3
  • 15
    • 0028350601 scopus 로고
    • Mutation of a mutL homologue in hereditary colon cancer
    • Papadopoulos N., Nicolaides N.C., Wei Y.F.et al. Mutation of a mutL homologue in hereditary colon cancer. Science. 263:1994;1625-1629.
    • (1994) Science , vol.263 , pp. 1625-1629
    • Papadopoulos, N.1    Nicolaides, N.C.2    Wei, Y.F.3
  • 16
    • 0028301255 scopus 로고
    • Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability
    • Umar A., Boyer J.C., Thomasm D.C.et al. Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J. Biol. Chem. 269:1994;14367-14370.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14367-14370
    • Umar, A.1    Boyer, J.C.2    Thomasm, D.C.3
  • 17
    • 0028877162 scopus 로고
    • Microsatellite instability in gynecological sarcomas and hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity
    • Risinger J.I., Umar A., Boyer J.C.et al. Microsatellite instability in gynecological sarcomas and hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. Cancer Res. 55:1995;5664-5669.
    • (1995) Cancer Res. , vol.55 , pp. 5664-5669
    • Risinger, J.I.1    Umar, A.2    Boyer, J.C.3
  • 18
    • 0028859671 scopus 로고
    • Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
    • Liu B., Nicolaides N.C., Markowitz S.et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet. 9:1995;48-55.
    • (1995) Nature Genet. , vol.9 , pp. 48-55
    • Liu, B.1    Nicolaides, N.C.2    Markowitz, S.3
  • 20
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
    • Koi M., Umar A., Chauhan D.P.et al. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54:1994;4308-4312.
    • (1994) Cancer Res. , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3
  • 21
    • 0031658679 scopus 로고    scopus 로고
    • Absence or decreased levels of the hMLH1 protein in human gastric carcinoma cell lines: Implication of hMLH1 in alkylation tolerance
    • Shin K.-H., Yang Y.-M., Park J.-G. Absence or decreased levels of the hMLH1 protein in human gastric carcinoma cell lines. implication of hMLH1 in alkylation tolerance J. Cancer Res. Clin. Oncol. 124:1998;421-426.
    • (1998) J. Cancer Res. Clin. Oncol. , vol.124 , pp. 421-426
    • Shin, K.-H.1    Yang, Y.-M.2    Park, J.-G.3
  • 22
    • 0027292234 scopus 로고
    • An alkylation-tolerance, mutator human cell line is deficient in strand-specific mismatch repair
    • Kat A., Thilly W.G., Fang W., Longley M.J., Li G.M., Modrich P. An alkylation-tolerance, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA. 90:1993;6424-6428.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6424-6428
    • Kat, A.1    Thilly, W.G.2    Fang, W.3    Longley, M.J.4    Li, G.M.5    Modrich, P.6
  • 23
    • 0030479125 scopus 로고    scopus 로고
    • Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea
    • Liu L., Markowitz S., Gerson S.L. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res. 56:1996;5375-5379.
    • (1996) Cancer Res. , vol.56 , pp. 5375-5379
    • Liu, L.1    Markowitz, S.2    Gerson, S.L.3
  • 24
  • 25
    • 0030834332 scopus 로고    scopus 로고
    • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
    • Friedman H.S., Johnson S.P., Dong Q.et al. Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. Cancer Res. 57:1997;2933-2936.
    • (1997) Cancer Res. , vol.57 , pp. 2933-2936
    • Friedman, H.S.1    Johnson, S.P.2    Dong, Q.3
  • 26
    • 0028533694 scopus 로고
    • DNA damage tolerance, mismatch repair and genome instability
    • Karran P., Bignami M. DNA damage tolerance, mismatch repair and genome instability. BioEssays. 16:1995;833-839.
    • (1995) BioEssays , vol.16 , pp. 833-839
    • Karran, P.1    Bignami, M.2
  • 27
    • 0025321564 scopus 로고
    • Characteristics of cell lines established human gastric carcinoma
    • Park J.-G., Frucht H., LaRocca R.V.et al. Characteristics of cell lines established human gastric carcinoma. Cancer Res. 50:1990;2773-2780.
    • (1990) Cancer Res. , vol.50 , pp. 2773-2780
    • Park, J.-G.1    Frucht, H.2    Larocca, R.V.3
  • 28
    • 0031038107 scopus 로고    scopus 로고
    • Establishment and characterization of human gastric carcinoma cell lines
    • Park J.-G., Yang H.-K., Kim W.H.et al. Establishment and characterization of human gastric carcinoma cell lines. Int. J. Cancer. 70:1997;443-449.
    • (1997) Int. J. Cancer , vol.70 , pp. 443-449
    • Park, J.-G.1    Yang, H.-K.2    Kim, W.H.3
  • 29
    • 0028556486 scopus 로고
    • Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β
    • Park K., Kim S.-J., Bang Y.-J.et al. Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells. correlation with sensitivity to growth inhibition by TGF-β Proc. Natl. Acad. Sci. USA. 91:1994;8772-8776.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8772-8776
    • Park, K.1    Kim, S.-J.2    Bang, Y.-J.3
  • 30
    • 0028785602 scopus 로고
    • A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability
    • Myeroff L.L., Parsons R., Kim S.-J.et al. A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res. 55:1995;5545-5547.
    • (1995) Cancer Res. , vol.55 , pp. 5545-5547
    • Myeroff, L.L.1    Parsons, R.2    Kim, S.-J.3
  • 31
    • 0003903343 scopus 로고
    • Molecular Cloning: A Laboratory Manual
    • Cold Spring Harbor, New York: Cold Spring Harbor Laboratory
    • Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning. A Laboratory Manual 2nd edn. 1989;Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
    • (1989) 2nd Edn.
    • Sambrook, J.1    Fritsch, E.F.2    Maniatis, T.3
  • 32
    • 0028223139 scopus 로고
    • Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal oral keratinocytes
    • Shin K.-H., Min B.-M., Cherrick H.M., Park N.-H. Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal oral keratinocytes. Mol. Carcinogenesis. 9:1994;76-86.
    • (1994) Mol. Carcinogenesis , vol.9 , pp. 76-86
    • Shin, K.-H.1    Min, B.-M.2    Cherrick, H.M.3    Park, N.-H.4
  • 33
    • 0025808242 scopus 로고
    • Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
    • Lassar A.B., Davis R.L., Wright W.E.et al. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell. 66:1991;305-315.
    • (1991) Cell , vol.66 , pp. 305-315
    • Lassar, A.B.1    Davis, R.L.2    Wright, W.E.3
  • 34
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane M.F., Loda M., Gaida G.M.et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57:1997;808-811.
    • (1997) Cancer Res. , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3
  • 35
    • 0031015728 scopus 로고    scopus 로고
    • BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines
    • Hoang J.-M., Cottu P.H., Thuille B., Salmon R.J., Thomas G., Hamelin R. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res. 57:1997;300-303.
    • (1997) Cancer Res. , vol.57 , pp. 300-303
    • Hoang, J.-M.1    Cottu, P.H.2    Thuille, B.3    Salmon, R.J.4    Thomas, G.5    Hamelin, R.6
  • 36
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman J.G., Umar A., Polyak K.et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. 95:1998;6870-6875.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3
  • 37
    • 84991420792 scopus 로고    scopus 로고
    • Proficiency of mismatch repair activity can be retained in spite of low expression levels of the hMLH1 gene in the HCT116 colon cancer cell line
    • Chauhan D.P., Yang Q.H., Marra G.et al. Proficiency of mismatch repair activity can be retained in spite of low expression levels of the hMLH1 gene in the HCT116 colon cancer cell line. Gastroenterology. 45(4SS):1996;A502.
    • (1996) Gastroenterology , vol.45 , Issue.4 , pp. 502
    • Chauhan, D.P.1    Yang, Q.H.2    Marra, G.3
  • 38
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • Fink D., Aebi S., Howell S.B. The role of DNA mismatch repair in drug resistance. Clin. Cancer Res. 4:1998;1-6.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1-6
    • Fink, D.1    Aebi, S.2    Howell, S.B.3
  • 39
    • 0031843622 scopus 로고    scopus 로고
    • Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents
    • Dosch J., Christmann M., Kaina B. Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents. Carcinogenesis. 19:1998;567-573.
    • (1998) Carcinogenesis , vol.19 , pp. 567-573
    • Dosch, J.1    Christmann, M.2    Kaina, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.