Endothelins and the role of endothelin antagonists in the management of posttraumatic vasospasm

Current Pharmaceutical Design

Volumn 10, Issue 18, 2004, Pages 2185-2192

  Armstead, W M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Brain injury; Cerebral circulation; Endothelin; K+ channels; Newborn; Oxygen free radicals

Indexed keywords

27 O [3 [2 (3 CARBOXYACRYLOYLAMINO) 5 HYDROXYPHENYL]ACRYLOYLOXY]MYRICERONE; ANTISENSE OLIGODEOXYNUCLEOTIDE; BQ 610; CYCLIC AMP; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR; INDOMETACIN; MONOCLONAL ANTIBODY; NOCICEPTIN; OPIATE; PHOSPHORAMIDON; POTASSIUM CHANNEL; POTASSIUM ION; PROSTAGLANDIN; PROTEIN KINASE C; R 061179B; UNCLASSIFIED DRUG; VASOPRESSIN;

AGING; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN VASOSPASM; CEREBROSPINAL FLUID; HEMODYNAMICS; HYPOTENSION; IMMUNOREACTIVITY; MOLECULAR INTERACTION; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RECEPTOR BINDING; REVIEW; SPECIES DIFFERENCE; SUBARACHNOID HEMORRHAGE;

ANIMALS; BRAIN INJURIES; ENDOTHELINS; HUMANS; RECEPTORS, ENDOTHELIN; VASOSPASM, INTRACRANIAL;

EID: 3042591642     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043384178     Document Type: Review

References (128)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kabayashi M, Mitsui Y, et al. A novel potent vasoconstrictor peptide produced by the vascular endothelial cells. Nature 1988; 332: 411-13.
2. Zimmerman M, Volker S. Endothelin and subarachnoid hemorrhage: An overview. Neurosurgery 1998; 43: 863-76.
3. Salom J, Torregrosa G, Alborch E. Endothelins and the cerebral circulation. Cerebrovascular and Brain Metabolism Reviews 1995; 7: 131.
4. Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, et al. Enclothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 1990; 172: 1741-48.
5. Ehrenreich H, Kehrl JH, Anderson W, Rieckmann P, Vitkovic L, Coligan JE, et al. A vasoactive peptide, endothelin-3, is produced by and specifically binds to primary astrocytes. Brain Res 1991; 538: 54-8.
6. Lee ME, de la Monte SM, Ng SC, Bloch DB, Quertemous T. Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest 1990; 86: 141-7.
7. Schini VB, Hendrickson H, Heublein DM. Thrombin enhances the release of endothelin from porcine aortic endotheliai cells. Eur J Pharmacol 1989; 165: 333-4.
8. Kasuya H, Weir BKA, White DM, Stefanson K. Mechanism of oxyhemoglobin-induced release of endothelin-1 from cultured vascular endothelial cells and smooth muscle cells. J Neurosurg 1993; 79: 892-8.
9. Yoshizumi M, Takaku F, Yanagisawa M, Masaki T, Yazaki Y. Interleukin 1 increased tile production of endothelin-1 by cultured endothelial cells. Biochem Biophys Res Commun 1990; 166: 324-9.
10. Yangisawa M, Masaki T. Molecular biology and biochemistry of the endothelins. Trends Pharmacol Sci 1989; 10: 374-8.
11. Boulanger C, Luscher TF. Release of endothelin from porcine aorta. Inhibition by endothelium derived nitric oxide. J Clin Invest 1990; 85: 587-90.
12. Bacic F, Uematsu S, McCarron RM, Spatz M. Secretion of immunoreactive endothelin-1 by capillary and microvascular endothelium of human brain. Neurochem Res 1992; 17: 699-702.
13. Ehrenheich H, Anderson RW, Ogino Y, Rieckmann P, Costa T, Wood GP, et al. Selective autoregulation of endothelins in primary astrocyte cultures: Endothelin receptor mediated potentiation of endothelin-1 secretion. New Biol 1911; 2: 135-41.
14. Giaid A, Gibson SJ, Ibrahim NBN, Legon S, Bloom SR, Yanagisawa M, et al. Endothelin-1: an endothelial derived peptide is expressed in neurons of the human spinal cord and dorsal root ganglia. Proc Natl Acad Sci USA 1989; 7364-38.
15. Randall MD, Douglas SA, Hiley CR. Vascular activities of endothelin-1 and some alanyl-substituted analogues in resistance beds of the rat. Br J Pharmacol 199; 98: 685-99.
16. Davenport AP, O'Reilly G, Molenaar P, Maguire JJ, Kuc RE, Sharkey A. Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in-situ hybridization and subtype selective ligands BQ123 and BQ3020: evidence for expression of ET-B receptors in human vascular smooth muscle. J Cardiovasc Pharmacol 1993; 22: 22-5.
17. B receptor mediates both vasodilatation and vasoconstriction in vivo. Biochem Biophys Res Commnun 1992; 186: 867-73.
18. B receptor-mediated constriction in the rabbit basilar artery. European Journal of Pharmacology 1988; 350: R7-9.
19. Williams DI, Jr, Jones KL, Pettibone DJ, Lis EV, Clineschmidt BV. Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes. Biochem Biophys Res Commun 1991; 175: 556-561.
20. 125. BQ-3020, reveals the localization of endothelin ET-B receptors. Eur J Pharmacol 1993; 235: 95-100.
21. Fukuroda T, Nishikibe M, Ohta Y, Ihara M, Yano M, Ishikawa K, et al. Analysis of response to endothelin in isolated porcine blood vessels by using a novel endothelin antagonist, BQ123. Life Sci 1992; 107:12.
22. Ishikawa K, Ihara M, Noguchi K, Mase T, Mino N, Saeki T, et al. Biochemical and pharmacological profile ofa potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci USA 1994; 91: 4892-96.
23. Faraci FM. Effects of endothelin and vasopressin on cerebral blood vessels. Am J Physiol 1989; 257: 1177-803.
24. Mima T, Yanagisawa M, Shigeno T, Saito A, Goto K, Takakura K, et al. Endothelin acts in feline and canine cerebral arteries from the adventitial side. Stroke 1989; 20: 1553-56.
25. Kobayashi H, Hayashi M, Kobayashi S, Kabuto M, Handa Y, Kawano H, et al. Cerebral vasospasm and vasoconstriction caused by endothelin. Neurosurgery 1991; 28: 673-8.
26. Willette RN, Sauermelch CF. Albuminal effects of endothelin in cerebral microvasculature assessed by laser-Doppler flometry. Am J Physiol 1990; 259: H1688-93.
27. Armstead WM, Mirro R, Leffler CW, Busija DW. Influence of endothelin on piglet cerebral microcirculation. Am J Physiol 1989; 257: H707-10.
28. Armstead WM. Role of endothelin in pial artery vasoconstriction and altered responses to vasopressin following brain injury. J Neurosurg 1996; 85: 901-7.
29. Salone JB, Torregrosa G, Alborch E. Endothelin and the cerebral circulation. Cerebral and Brain Metab Rev. 1995; 7:131-52.
30. Hardebo JE, Kahistrom J, Oamon C, Salford LG. Endothelin is a potent constrictor of human intracranial arteries and veins. Blood Vessels 1989; 26: 249-253.
31. Fukuda S, Taga K, Shimoji K. High sensitivity of porcine cerebral arteries to endothelin. Experientia 1991; 47: 475-7.
32. Weir B. The pathophysiology of cerebral vasospasm. BJ Neurosurg 1995; 9: 375:390.
33. Yamaji T, Joshita H, Istribashi M, Takaku F, Ohno H, Suzuki N, et al. Endothelin family in human plasma and cerebrospinal fluid. Clinical Endocrinol Metab 1990; 71: 1611:15.
34. Hirata Y, Matsanaga T, Ando K, Funukawa T, Tsukagoshi H, Marumo F. Presence of endothelin-1-like immunioreactivity in human cerebrospinal fluid. Biochem Biophys Res Commun 1990; 166: 1274-78.
35. Susuki H, Sato S, Susuki Y, Takekoshi K, Ishihare N, Shimota S. Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage. Acta Neurol Scand 1990; 81: 553-4.
36. Kraus G, Bucholz R, Yoon K, Knupfer M, Smith K. Cerebrospinal fluid endothelin-1 and endothelin-3 levels in normal and neurosurgical patients: A clinical study and literature review. Surg Neurol 1991; 35: 20-9.
37. Suzuki H, Soto S, Suzuki Y, Tsuchiya T, Lino I, Yamanaka T, et al. Endothelin immunoreactivity in cerebrospinal fluid of patient with subarachnoid hemorrhage. Ann Medicine 1990; 233-6.
38. Fujimosi A, Yamagisawa M, Saito A, Goto K, Masaki T, Mima T, et al. Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid hemorrhage. Lancet 1990; 336-633.
39. Suzuki R, Masaoka H, Hirata Y, Marumo F, Isotani E, HiraKawa K. The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neuosurg 1992; 77: 96-100.
40. Seifert V, Loffler BM, Zimmerman M, Roax S, Stoke D. Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation ith cerebral vasospasm, delayed ischemic neurologic deficits and volume of hematoma. J Neurosurg 1995; 82: 55-62.
41. Barone FC, Globus MYT, Price WJ, White RF, Storer BL, Feuerstein GZ, et al Endothelin levels increase in rat focal and global ischemia. J Art Blood Flow Metob 1994;14: 337-342.
42. Willette RN, Ohlstein EH, Pullen M, Sauermelch CF, Chen A, Nambi P. Transient forebrain ischemia alters acutely receptor density and immunoreactivity in gerbil brain. Life Sci 1992; 52: 35-40.
43. Yamaura I, Tani E, Malda Y, Minarmi N, Shindo H, Endothelin-1 of canine basilar artery. J Neurosurg 1992; 76: 99-105.
44. MacArthur H, Warner TD, Wood EG, Corder R, Vane JR. Endotheli-1 released from cells in culture is elevated both acutely and chronically by short periods of mechanical stretch. Biochem Biophys Res Commun 1994; 200: 395-400.
45. Elton TS, Oparil S, Taylor GR, Hicks PH, Yang RH, Jin H, et al. Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am J Physiol 1992; 236: R1260-64.
46. Kurihara H, Yoghizumi M, Sugiyoma T, Takaku F, Yamagisawa M, Mogaki T, et al. Transforming growth factor - B stimulates expression of endothelin mRNA by vascular endothelial cells. Biochem Bi-phys Res Commun 1989; 159: 1435-40.
47. Matsumura Y, Ikegawa R, Suzuki Y, Takaoka M, Uchida T, Kido H, et al. Phosphoramidon prevents cerebral vasospasm following subarachnoid hemorrhage in dogs; the relationship to endothelin-1 levels in the cerebrospinal fluid. Life Sci 1991; 49: 841-8.
48. Onoda K, Shigeki O, Ogihara K, Shiota T, Asari S, Ohmoto, et al. Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligo DNA in a rat experimental vasospasm model. J Neurosurg 1996; 85: 846-852.
49. Cosentino F, McMahon EG, Carter JS, Katusic ZS. Effect of endothelin-A-receptor antagonist BQ 123 and phosphoramidon on cerebral vasospasm. J Cardio Vasc Pharmacol 993; 22: 332-5.
50. Clozel M, Watanabe H. BQ-123, a peptidic endothelin receptor antagonist prevents the early cerebral vasospasm following subarachnoid hemorrhages after intracisternal but not intravenous injection. Life Sci 1993; 52: 825-34.
51. Itoh S, Sasaki T, Asai A, Kuchino Y. Prevention of delayed vasospasm by an endothelin ETA receptor antagonist. BQ 123: Change of ETA receptor mRNA expressions in a canine subarachnoid hemorrhage model. J Neurosurg 1994; 81: 759-764.
52. Matsuo Y, Mihara S, Ninomoya M, Fajirmoto M. Protective effect of endothelium type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats. Stroke 2001; 32: 2143-8.
53. Dawson DA, Sagano H, McCarron RM, HalenGreek JM, Spatz M. Endothelin receptor antagonist preserves microvascular perfusion and reduces ischemic brain damage following permanent focal ischemia. Neurochem Res 1999; 24: 1499-505.
54. Lehmberg J, Putz C, Furst M, Beck J, Baethmann A, Uhl E. Impact of the endothelin-A receptor antagonist BQ-610 on microcirculation in global cerebral ischemia and reperfusion. Brain Res 2003; 961: 277-86.
55. Shigeno T, Clozel M, Sakai S, Saito A, Goto K. The effect of bosentan, a new potent endothelin receptor antagonist on the pathogenesis of cerebral vasospasm. Neurosurg 1995; 37: 87-91.
56. Patel T, McCulloch J. Failure of an endothelin antagonist to modify hypoperfusion after transient global ischemia in he rat. J Cereb Blood Flow Metab 1996; 16: 490-9.
57. B receptors in rats. Stroke 2002; 33: 2311-6.
58. Zuccarello M, Boccaletti R, Romano A, Rapoport RM. Endothelin B receptor antagonists attenuate subarachnoid hemorrhage induced cerebral vasospasm. Stroke 1998; 1924-9.
59. Chuquet J, Benchemare K, Toutain J, Mackenzie ET, Roussel S, Touzani O. Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat. Stroke 2002; 33: 3019-25.
60. Siren AL, Lewszuk P, Hasselblatt M, Dembowski C, Schilling L, Ehrenreich H. Endothelin-B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo. Brain Res 2002; 942: 144-9.
61. Alabadi JA, Torregrosa G, Miranda FJ, Salom JB, Centeno JM, Alborch E. Impairment of the modulatory role of nitric oxide on the endothelin-1-elicited contraction of cerebral arteries: a pathogenic factor in cerebral vasospasm after subarachnoid hemorrhage? Neurosurg 1997; 41: 245-53.
62. Beath W, Kasprzak H, Kotschy M, Wozniak B, Kulwas A, Saiegock M. Endothelin in the plasma and cerebrospinal fluid of patients after head injury. Neurol Neuro chirugica Polska 2001; 35: 125-9.
63. Herne H, Kasuya Y, Sakurai T, Yarnada G, Suzuki N, Nasaki T, et al. Role of endothelin-1 in astrocytic responses after acute brain damage. J Neurosci Res 1997; 47: 590-602.
64. Siren AL, Knerlich F, Schilling L, Kamcowski-Kruck H, Hahn A, Ehrenreich H. Differential glial and vascular expression of endothelins and their receptors in cat brain after neurotrauma. Neurochem Res 2000; 25: 957-969.
65. Gerlach L, Siren AL, Knerlich F, Feger G, Fricke A, Barth M, et al. Delayed loss of ETB receptor-mediated vasorelaxation after cold lesion of the rat parietal cortex. J Cereb Blood Flow Metals 1998; 18: 1357-64.
66. Barone FC, Ohlstein FH, Hunter AJ, Campbell CA, Hadingham SH, Parsons AA, et al. Selective antagonism of endothelin A receptors improves outcome in both head trauma and focal stroke in rat. J Cardiovasc Pharmacol 2000; 36: S357-S361.
67. Duhaime AC, Raghupathi R. Age-specific therapy for traumatic injury of the immature brain: experimental approaches. Exp Toxic Pathol 1999; 51: 172-7.
68. Dickerson JWT, Dobbing J. Prenatal and postnatal growth and development of the central nervous system of the pig. Proc R Soc Lond 1967; 166: 384-95.
69. Buckley NM. Maturation of circulatory system in three mammalian models of human development. Comp Biochem Physiol 1986; 83: 107.
70. Pampiglione G. Some aspects of development of cerebral function in mammals. Proc R Soc Lond 1971; 64: 429-35.
71. Duhaime AC, Gennarelli LM, Broadman C. Neuroprotection by dextromethorphan in acute subdural hematoma in rat. J Neurotrauma 1995; 13: 79-84.
72. Shaver E, Duhaime AC, Curtis M, Gennarelli LM, Barrett R. Experimental acute subdural hematoma in infant piglets. Pediatr Neurosurg 1996; 25: 123-9.
73. Tepas JJ III, Dokler ML. Critical care of the injured child. Semin Pediatr Surg 1995; 4: 120-7.
74. Wei EP, Eietrich WH, Puvlishock JT, Navari RM, Kontos HA. Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ Res 1980; 46: 37-47.
75. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soars H, et al. Traumatic brain injury in the rat: Characterization of a lateral fluid percussion model. Neuroscience 1989; 28: 233-44.
76. Adelson PD, Dixon CE, Robicaud P, Kochanek PM. Motor and cognitive functional deficits following diffuse traumatic brain injury in the immature rat. J Neurotrauma 1997; 14: 99-108.
77. Smith SL, Andous PK, Gleason DG, Hall ED. Infant rat model of the shaken baby syndrome: Preliminary characterization and evidence for the role of free radicals in cortical hemorrhaging and progressive neuronal degeneration. J Neurotrauma 1998; 15: 693-705.
78. Prins ML, Lee SM, Cheng CLY, Becker DP, Hova DA. Fluid percussion brain injury in the developing and adult rat: A comparative study of mortality, morphology intracranial pressure and mean arterial blood pressure. Dev Brain Res 1996; 95: 272-82.
79. Armstead WM, Kurth CD. Different cerebral hemodynamic responses following fluid percussion brain injury in the newborn and juvenile pig. J Neurotrauma 1994; 11: 487-97.
80. Dobbing J. The later development of the brain and its vulnerability. In: Davis JA, Dobbing J. Eds. Scientific Foundations of Pediatrics. London: Heineman Medical 1981; pp 744-59.
81. Armstead WM. Role of endothelin in pial artery vasoconstriction and altered responses to vasopressin following brain injury. J Neurosurgery 1996; 85: 901-7.
82. Armstead WM. Role of opioids in the physiologic and pathophysiologic control of the cerebral circulation. Proc Soc Exp Biol Med 1997; 214: 210-21.
83. Faraci FM, Heistad DB. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev 1998; 78: 53-97.
84. Nelson MT, Pollak JB, Worley JF, Standen NB. Calcium channels, potassium channels and voltage dependence of arterial smooth muscle tone. Am J Physiol 1990; 259: C3-18.
85. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995; 268: C799-C822.
86. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34: 216-22.
87. Luerssen TG, Klauber MR, Marshall LL. Outcome from head injury related patient's age: a longitudinal prospective study of adult and pediatric head injury. J Neurosurg 68; 408: 409-16.
88. DeWitt DS, Prough DS, Taylor CL, Whitley JM, Deal DD, Vines SM. Regional cerebrovascular responses to progressive hypotension after traumatic brain injury in cats. Am J Phsyiol 1992; 263: H1276-84.
89. Lewelt W, Jenkins LW, Miller JD. Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain. J Neurosurg 1980; 53: 500-11.
90. Leffler CW, Busija DW. Prostanoids and pial arteriolar diameter in hypotensive newborn pigs. Am J Physiol 1987; 252: H687-H691.
91. Leffler CW, Busija DW, Beasley DG, Fletcher AM. Maintenance of cerebral circulation during hemorrhagic hypotension in newborn pigs: role of prostanoids. Circ Res 1986; 59: 562-7.
92. ca channel activation. Brain Res 1999; 815: 158-164.
93. + channel function in altered cerebral hemodynamics following brain injury. Brain Res 1997; 768: 177-84.
94. + channel function in piglet cerebral arteries. Stroke 1997; 29: 2273-80.
95. + channel function after brain injury. Am J Physiol 1997; 273: H2639-47.
96. Kasemsri T, Armstead WM. Endothelin production links superoxide generation to altered opioid-induced pial artery vasodilatin after brain injury in pigs. Stroke 1997; 28: 190-7.
97. + channel function after brain injury. Stroke 1999; 30: 153-9.
98. + channel function impairment after brain injury. J Neurotrauma 2001; 18: 1039-48.
99. + channels. Am J Physiol 1995; 269: H997-H1002.
100. + channels and cAMP in opioid-induced pial artery dilation. Brain Res 1997; 747: 252-8.
101. Armstead WM. Role of endothelin-1 in age dependent cerebrovascular hypotensive responses after brain injury. Am J Physiol 1999; 274: H1884-94.
102. Watson DB, Busto R, Goldberg WJ, Santiso M, Yoshida S, Ginsberg MD. Lipid peroxidation in vivo induced by reversible global ischemia in rat brain. J Neurochem 1984; 41: 268-74.
103. Leffler CW, Busija DW, Armstead WM. Activated oxygen and arachidonate effects on newborn cerebral arterioles. Am J Physiol 1990; 259: H1230-38.
104. Wei EP, Christman W, Kontos HA, Povlishock JT. Effects of oxygen radicals on cerebral arterioles. Am J Physiol 1985; 248: H156-67.
105. Wei EP, Kontos HA, Christman VC, DeWitt DS, Povlishock JT. Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension. Cir Res 1985; 57: 781-7.
106. Beckman JS. Peroxynitrite versus hydoxyl radical: the role of nitric oxide in superoxide-dependent cerebral injury. Ann NY Acad Sci 1994; 738: 69-75.
107. Lipton SA, Choi YB, Pan ZH. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso compounds. Nature 1993; 364: 626-32.
108. Laher I, Zhang J. Protein kinase C and cerebral vasospasm. J Cereb Blood Flow Metab 2001; 21: 887-06.
109. ea channel cerebrovasodilation. Am J Physiol 2003; 285: R149-R154.
110. Hicks RR, Martin VB, Zhang L, Seroogy KB. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp Neurol 1999; 160: 469-78.
111. Oyesiku NM, Evans CO, Houston S, Darrell RS, Smith JS, Fulop ZL, et al. Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brian. Brain 1999; 833: 161-72.
112. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and independent mechanisms. Science 1999; 286: 1358-62.
113. Otani N, Mawashiro H, Fukui S, Nomura N, Shima K. Temporal and spatial profile of phosphorylated mitogen-activated protein kinase pathways after lateral fluid percussion injury in the cortex of the rat brain. J Neurotrauma 2002; 19: 1587-96.
114. ca channel impairment after brain injury. Brain Res 2002; 943: 276-82.
115. Higashijima T, Burnier J, Ross EM. Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. J Biol Chem 1990; 265: 14176-86.
116. Klinker JA, Hageluken A, Grunbaum L, Heilmann I, Nurnberg B, Harhammer R, et al. Mastoparan may activate GTP hydrolysis by G-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase. Biochem J 1994; 305: 377-83.
117. Klinker JE, Laugwitz L-L, Hageluken A, Seifert R. Activation of GTP formation and high affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action. Biochem Pharmacol 1996; 51: 217-23.
118. Armstead WM. Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury. Brain Res 2003; 971: 154-60.
119. Komaru T, Tanikawa T, Surimura A, Kumagai T, Sato K, Kanatsuka H. Mechanisms of coronary microvascular dilation induced by the activation of pertussis toxin sensitive G proteins are vessel size dependent. Cir Res 1997; 80: 1-10.
120. ca channels. Brain Res 2002; 957: 369-72.
121. Armstead WM. ET-1 contributes to age dependent G protein impairment after brain injury. J Neurotrauma 2003; 20: 105-10.
122. Armstead WM. Age dependent endothelin contribution to NOC/oFQ induced impairment of NMDA cerebrovasodilation after brain injury. Peptides 2001; 22: 39-46.
123. Armstead WM. Role of nociceptin/orphanin FQ in the physiologic and pathologic control of the cerebral circulation. Exp Biol and Med 2002; 227: 957-68.
124. Philip S, Armstead WM. Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation. Brain Res 2003; 979: 98-103.
125. Armstead WM. PTK, ERK, and p38 MAPK contribute to impaired NMDA vasodilation after brain injury. Eur J Pharmacol 2003; 474: 249-54.
126. Horani MH, Mooradian AD. Effect of diabetes on the blood brain barrier. Curr Pharm Design 2003; 9(10): 833-40.
127. Morbidelli L, Donnini S, Ziche M. Role of nitric oxide in the modulation of angiogenesis. Curr Pharm Design 2003; 9(7): 521-30.
128. Taddei S, Ghiadoni L, Virdis A, Versari D, Salvetti A. Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies. Curr Pharm Design 2003; 9(29): 2385-402.