Endothelin impairs ATP-sensitive K+ channel function after brain injury

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 273, Issue 6 42-6, 1997, Pages

  Kasemsri, T ^a   Armstead, W M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Cerebral circulation; Cyclic nucleotides; Newborn; Nitric oxide

Indexed keywords

8 BROMO CYCLIC GMP; CALCITONIN GENE RELATED PEPTIDE; CROMAKALIM; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; N ACETYL S NITROSOPENICILLAMINE; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

ANIMAL MODEL; ARTICLE; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN INJURY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

EID: 0031425131     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.273.6.h2639     Document Type: Article

References (17)

1. + channel function in piglet cerebral arteries. Stroke. In press.
2. + channels in NO- and hypoxia-induced pial artery vasodilation. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1785-H1790, 1997.
3. Armstead, W. M. Influence of brain injury on vasopressin-induced pial artery vasodilation: role of Superoxide anion. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1272-H1278, 1996.
4. + channels in cGMP-mediated pial artery vasodilation. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H423-H426, 1996.
5. Armstead, W. M. Role of endothelin in pial artery vasoconstriction and altered responses to vasopressin following brain injury. J. Neurosurg. 85: 901-907, 1996.
6. Armstead, W. M. Relationship between opioids and activation of phospholipase C and protein kinase C in brain injury induced pial artery vasoconstriction. Brain Res. 689: 183-188, 1995.
7. Armstead, W. M., and C. D. Kurth. Different cerebral hemodyamic responses following fluid percussion brain injury in the newborn and juvenile pig. J. Neurotrauma 11: 487-497, 1994.
8. Armstead, W. M., R. Mirro, C. W. Leffler, and D. W. Busija. Influence of endothelin on piglet cerebral microcirculation. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H707-H710, 1989.
9. + channels and nitric oxide on pial arterioles in piglets. J. Cereb. Blood Flow Metab. 16: 1158-1164, 1996.
10. + channel function in cerebral arterioles in piglets. Stroke 27: 1874-1881, 1996.
11. + current in freshly dispersed cerebral arterial muscle cells. Pflügers Arch. 418: 292-296, 1991.
12. Edvinsson, L., R. Ekman, I. Jansen, J. McCulloch, and R. Uddman. Calcitonin gene related peptide and cerebral blood vessels: distribution and vasomotor effects. J. Cereb. Blood Flow Metab. 7: 720-728, 1987.
13. Ferrer, M., A. Encabo, J. Marin, C. Peiro, J. Redondo, M. R. de Sagarra, and G. Balfagon. Comparison of the vasoconstrictor responses induced by endothelin and phorbol 12,13-dibutyrate in bovine cerebral arteries. Brain Res. 599: 186-196, 1992.
14. Gennarelli, T. A. Animate models of human head injury. J. Neurotrauma 11: 357-368, 1994.
15. Greenberg, D., J. Chan, and H. Sampson. Endothelin and the nervous system. Neurology 42: 25-31, 1992.
16. Hosli, E., and I. Hosli. Autoradiographic evidence for endothelin receptors on astrocytes in cultures of rat cerebellum, brainstem, and spinal cord. Neurosci. Lett. 129: 55-58, 1991.
17. Inoue, A., M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto, and T. Masaki. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA 86: 2863-2867, 1989.