Failure of an endothelin antagonist to modify hypoperfusion after transient global ischaemia in the rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 3, 1996, Pages 490-499

  Patel, Toshal R ^a   McCulloch, James ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Autoradiography; Bosentan; Endothelin; Endothelin receptor antagonists; Forebrain ischaemia; Hydrogen clearance

Indexed keywords

BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; HYDROGEN; IODOPHENAZONE C 14;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN REGION; CAROTID ARTERY OBSTRUCTION; COMMON CAROTID ARTERY; CONTROLLED STUDY; HEMORRHAGIC HYPOTENSION; HYDROGEN CLEARANCE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029865103     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199605000-00016     Document Type: Article

References (61)

1. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S (1990) Cloning and expression of a cDNA encoding an endothelin receptor. Nature 348:730-2
2. Barone FC, Globus MY-T, Price WJ, White RF, Storer BL, Feuerstein GZ, Busto R, Ohlstein EH (1994) Endothelin levels increase in rat focal and global ischaemia, J Cereb Blood Flow Metab 14:337-42
3. Brunner F, du Toit E, Opie L (1992) Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts. J Mol Cell Cardiol 24:1291-305
4. Clozel M, Breu V, Gray GA, Kalina B, Loffler B-M, Burri K, Cassal J-M, Hirth G, Muller M, Neidhart W, Ramuz H (1994) Pharmacological characterisation of Bosentan. a new potent orally active non-peptide endothelin receptor antagonist. J Pharmacol Exp Ther 270:228-35
5. B receptor mediates vasodilatation and vasoconstriction in vivo. Biochem Biophys Res Commun 186:867-73
6. Coyle P, Jokelainen PT (1982) Dorsal cerebral arterial collaterals of the rat. Anat Rec 203:397-404
7. del Zoppo GJ (1994) Microvascular changes during cerebral ischaemia and reperfusion. Cerebrovasc Brain Metab Rev 6: 47-96
8. Dirnagl U, Niwa N, Sixt G, Villringer A (1994) Cortical hypoperfusion after global forebrain ischaemia in rats is not caused by microvascular plugging. Stroke 25:1028-38
9. Duverger D, Viossat I, Chapelat M, Chabrier P-E, Pirotsky E, Braquet P (1992) Focal ischaemia in the rat: measurement of brain tissue endothelin. Circ Metab Cerveau 9:85-93
10. Ehrenreich H, Kehrl J, Anderson R, Rieckmann P, Vitkovic L, Coligan J, Fauci A (1991) A vasoactive peptide, endothelin-3 is produced by and specifically binds to primary astrocytes Brain Res 538:54-8
11. Feger GI, Schilling L, Ehrenreich H, Wahl M (1994) Endothelin-induced contraction and relaxation of rat isolated basilar artery: effect of BQ-123. J Cereb Blood Flow Metab 14:845-51
12. A) antagonist is neuroprotective in gerbil transient forebrain ischaemia. Stroke 25:264
13. Frerichs KU, Siren AL, Feuerstein GZ, Hallenbeck JM (1992) The onset of post ischaemic hypoperfusion in rats is precipitous and may be controlled by local neurones. Stroke 23: 399-406
14. Fuxe K, Kurosawa N, Cintra A, Hallstrom A, Goiny M, Rosen L, Agnati LF, Ungerstedt U (1992) Involvement of local ischaemia in endothelin-1 induced lesions of the neostriatum of the anaesthetised rat. Exp Brain Res 88:131-9
15. Giuffrida R, Bellomo M, Polizzi G, Malatino LS (1990) Ischaemia-induced changes in the immunoreactivity for endothelin and other vasoactive peptides in the brain of the mongolian gerbil. J Cardiovasc Pharmacol 20(suppl 12):S41-4
16. Giuffrida R, Malatino LS (1992) Endothelin and transient cere- bral ischaemia: an immunohistochemical study in the Mongolian gerbil. Brain Dysfunction 5:192-9
17. Grogaard B, Schurer L, Gerdin B, Arfors KE (1989) Delayed hypoperfusion after incomplete forebrain ischaemia in the rat: the role of polymorphonuclear leucocytes. J Cereb Blood Flow Metab 9:500-5
18. Hossmann K-A, Lechtape-Gruter H, Hossmann V (1973) The role of cerebral blood flow for the recovery of the brain after prolonged ischaemia. Z Neurol 29:375-84
19. Kagstrom E, Smith M-L, Seisjo B (1983) Recirculation in the rat brain following incomplete ischaemia. J Cereb Blood Flow Metab 3:183-92
20. Kazda S, Garthoff B, Krause HP, Schlossmann K (1982) Cerebrovascular effects of the calcium channel antagonistic dihydropyridine derivative nimodipine in animal experiments Arzneimittell-Forschung 32:331-8
21. B receptor and nitric oxide in cats. Neurosci Lett 176:157-60
22. Kurihara H, Yoshizumi M, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Hamaoki M, Kato H, Yazaki Y (1989) Transforming growth factor-β stimulates the expression endothelin mRNA by vascular endotheiial cells. Biochem Biophys Res Commun 159:1435-1440
23. Lopez-Farre A, Gomez-Garre D, Bernabeu F, Lopez-Novoa JM (1991) A role for endothelin in the maintenance of post ischaemic renal failure in the rat. J Physiol 444:513-22
24. MacCumber M, Ross C, Snyder S (1990) Endothelin in brain: receptor, mitogenesis and biosynthesis in glial cells. Proc Natl Acad Sci USA 87:2359-63
25. Macrae IM, Robinson MJ, Graham DI, Reid JL, McCulloch J (1993) Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course and neuropathological consequences. J Cereb Blood Flow Metab 13:276-84
26. Malek A, Izumo S (1992) Physiological fluid shear stress causes the downregulation of ET-1 mRNA in bovine aortic endothelium. Am J Physiol 263:C389-96
27. Masaki T. Vane J, Vanhoutte PM (1994) International Union of Pharmacology: nomenclature of endothelin receptors. Pharmacol Rev 46:137-42
28. McAuley MA, Patel TR, Galbraith S, McCulloch J (1994) Endothelin and its pathophysiological role in the cerebral circulation. In: Pharmacology of Cerebral Ischaemia (Krieglstein J, Oberpichler-Schwenk H, eds), Stuttgart, Wissenschaftliche Verlagsgesellschaft, pp 511-24
29. Mchedlishvili G, Kuridze N (1984) The modular organisation of the pial arterial system in phylogeny. J Cereb Blood Flow Metab 4:391-6
30. Miller C, Lampard DG, Alexander K, Brown WA (1980) Local cerebral blood flow following transient cerebral ischaemia I. Onset of impaired reperfusion within the first hour following global ischaemia. Stroke 11:534-41
31. Moskowitz MA, Macfarlane R, Tasdemiroglu E, Wei EP, Kontos HA (1990) Neurogenic control of the cerebral circulation during global ischaemia. Stroke 21(suppl III):III168-71
32. Ohlstein EH, Nambi P, Douglas SA, Edwards RM, Gellai M, Lago A, Leber JD, Cousins RD, Gao A, Frazee JS, Peishoff CE, Bean JW, Eggleston DS, Elshourbagy NA, Kumar C, Lee JA, Yue T-L, Louden C, Brooks DP, Weinstock J, Feuerstein G, Poste G, Ruffolo RR, Gleason JG, Elliot JD (1994) SB209670, a rationally designed potent non peptide endothelin receptor antagonist. Proc Natl Acad Sci USA 91:8052-6
33. Patel TR, Galbraith S, McAuley MA, McCulloch J (1995) Cerebrovascular significance of endothelin receptor antagonism in focal ischaemia J Cereb Blood Flow Metab 15 (suppl 1):S140
34. Patel TR, McAuley MA, McCulloch J (1994) Effects on feline pial arterioles in situ of Bosentan. a non-peptide, endothelin receptor antagonist. Eur J Pharmacol 260:65-71
35. Paxinos G, Watson GC (1986) The rat brain in stereotaxic coordinates. Academic Press
36. Pulsinelli WA, Levy DE, Duffy TE (1982) Regional cerebral blood flow and glucose metabolism following transient ischaemia. Ann Neurol 11:499-509
37. Robinson MJ, Macrae IM, Todd M, Reid JL, McCulloch J (1990) Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat. Neurosci Lett 118:269-72
38. Robinson MJ, McCulloch J (1990) Contractile responses to endothelin in feline cortical vessels in situ. J Cereb Blood Flow Metab 10:265-89
39. Rubanyi GM, Polokoff MA (1994) Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev 46:325-415
40. Sagher O, Jin Y, Thai QA, Fergus A, Kassell NF, Lee KS (1994) Cerebral microvascular responses to endothelins: the role of ET(A) receptors. Brain Res 658:179-84
41. 14C) antipyrine. Am J Physiol 234:1759-66
42. Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T (1990) Cloning of cDNA encoding a non isopeptide selective subtype of the endothelin receptor. Nature 348:732-5
43. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation 89:1203-8
44. Sharkey J, Ritchie IM, Kelly PAT (1993) Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab 13:865-71
45. B receptor in vascular endothelium and smooth muscle. Biochem Biophys Res Commun 191:459-64
46. Smith M-L, Auer RN, Seisjo BK (1984) The density and distribution of ischaemic brain injury in the rat following 2-10 min of forebrain ischaemia. Acta Neuropathol (Berl) 64:319-32
47. Snyder JV, Nemoto EM, Carrol RG, Safar P (1975) Global ischaemia in dogs: intracranial pressures, brain blood flow and metabolism. Stroke 6:21-7
48. Steen PA, Newberg LA, Milde JH, Michenfelder JD (1984) Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischaemia in the dog. J Cereb Blood Flow Metab 4:82-7
49. Suzuki R, Masaoka H, Hirata Y, Marumo F, Isotani E, Hirakawa K (1992) The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid haemorrhage. J Neurosurg 77:96-100
50. Viossat I, Duverger D, Chapelat M, Pirotsky E, Chabrier PE, Braquet P (1993) Elevated tissue endothelin content during focal ischaemia in the rat. J Cardiovasc Pharmacol 22(suppl 8):S306-9
51. Wade JG, Amtrop O, Sorensen SC (1975) No-flow state following cerebral ischaemia. Role of increase in potassium concentration in brain interstitial fluid. Arch Neural 32:381-4
52. Wahl M, Schilling L (1993) Mediators inducing stasis in cerebral microvessels during ischaemia. In: Microcirculatory Stasis in the Brain (Tomita M ed), New York, Elsevier Science Publishers, pp 305-10
53. Warner TD, Allcock GH, Corder R, Vane JR (1993) Use of the endothelin antagonists BQ-123 and PD-142893 to reveal 3 endothelin receptors mediating smooth-muscle contraction and the release of EDRF. Br J Pharmacol 110:777-82
54. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A (1990) Endothelin in myocardial infarction. Nature 344:114
55. Willette RN, Ohlstein EH, Pullen M, Sauermelch CE, Cohen A, Nambi P (1992) Transient forebrain ischaemia alters acutely endothelin receptor density and immunoreactivity in gerbil brain. Life Sci 52:35-40
56. Yamashita K, Kataoka Y, Niwa M, Shigematsu K, Himeno A, Koizumi S, Taniyama K (1993) Increased production of endothelins in the hippocampus of stroke prone spontaneously hypertensive rats following transient forebrain ischaemia: histochemical evidence. Cell Mol Neurobiol 13:15-23
57. B receptor aggregate in rat hippocampus CA1 subfields following transient forebrain ischaemia. J Neurochem 63: 1042-51
58. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-15
59. 2 clearance measurement of blood flow: a review of techniques and polarographic principles. Stroke 11:552-64
60. Zimmerman RS, Maymind M, Barbee RW (1994) Endothelin blockade lowers total peripheral resistance in haemorrhagic shock recovery. Hypertension 23:205-10
61. Ziv I, Heminger G, Djaldetti R, Achiron A, Melamed E, Sokolovsky M (1992) Increased plasma endothelin-1 in acute ischaemic stroke. Stroke 23:1014-16