Novel mechanism of Vitamin E protection against cyclosporine A cytotoxicity in cultured rat hepatocytes

Biochemical Pharmacology

Volumn 64, Issue 2, 2002, Pages 267-276

  Andrés, David ^a   Cascales, María ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Catalase; CsA; CuZnSOD; MnSOD; ROS; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOSPORIN A; GLUTATHIONE PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; INCUBATION TIME; LIPID PEROXIDATION; LIVER CELL CULTURE; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CYCLOSPORINE; DRUG INTERACTIONS; ENZYME INHIBITORS; HEPATOCYTES; MALE; PROTECTIVE AGENTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; VITAMIN E;

EID: 0037099381     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01112-7     Document Type: Article

References (38)

1. Immunosuppressive therapy
2. In vivo pharmacological effects of cyclosporin and some analoges
3. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK 506 complexes
4. The actions of cyclosporin A and FK 506 suggest a novel step in the activation of T Lymphocytes
5. Inhibition of drug metabolism in rat and human liver microsomes by FK506 and cyclosporin
6. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A
7. Cyclosporin metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporin-metabolizing enzyme explains interactions of cyclosporin with other drugs
8. Metabolism of cyclosporin
9. Studies of cyclosporin and metabolite toxicity in renal and hepatocyte culture systems
10. Cyclosporine A hepatotoxicity: Effect of prolonged treatment with cyclosporine on biliary lipid secretion in the rat
11. Cyclosporin-induced renal disfunction in experimental animals and humans
12. Role of glutathione in cyclosporin A in vitro hepatotoxicity
13. Cyclosporin A-induced oxidative stress in rat hepatocytes
14. Changes in antioxidant defence systems induced by cyclosporine A in cultures of hepatocytes from 2- and 12-month-old rats
15. HSP70 induction by cyclosporine A in cultured rat hepatocytes: Effect of vitamin E succinate
16. Biological antioxidant protection against lipid peroxidation damage
17. Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide
18. Isolation of hepatocytes by collagenase perfusion
19. Enzyme leakage as an indicator of cytotoxicity in cultured cells
20. Lactate dehydrogenase. UV-methods with pyruvate and NADH
21. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
22. Acceleration of nucleic acid hybridization rate by polyethylene glycol
23. Inhibitors of oxidative stress mimic the ability of follicle stimulating hormone to suppress apoptosis in cultures of rat ovarian follicles
24. Hydrogen-peroxide: Hydrogen-peroxide oxidoreductase (EC 1.11.1.6)
25. Superoxide dismutase, catalase and glutathione peroxidase in experimental and human brain tumors
26. An improved coupled test procedure for glutathione peroxidase in blood
27. Rapid and sensitive method for the quantification of microgram amounts of protein utilising the principle of protein-dye binding
28. Immunosuppression
29. Hepatotoxicity of intravenous cyclosporine A in patients with acute ulcerative colitis on total parenteral nutrition
30. The balance between Cu/Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress
31. Determination of the kinetic parameters for the "suicide substrate" inactivation of bovine liver catalase by hydrogen peroxide
32. Expression of genes coding for antioxidant enzymes and heat shock proteins is altered in primary cultures of rat hepatocytes
33. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondria-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase
34. Influence of cyclosporine A on the respiration of isolated rat kidney mitochondria
35. Inhibited efficiency of kidney mitochondria isolated from rats treated with cyclosporine A
36. Action of cyclosporine on mitochondrial calcium fluxes
37. Generation of oxygen free radicals during the metabolism of cyclosporine A: A cause-effect relationship with metabolism inhibition
38. Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity