Activation of refractory T cell responses against hepatitis C virus core protein by ablation of interfering hydrophobic domains

Molecular Therapy

Volumn 13, Issue 2, 2006, Pages 338-346

  Andersson, Helen A ^a,b,d   Singh, Rana A K ^a,b   Barry, Michael A ^a,b,c  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Rice University   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cellular immunity; Core protein; Genetic immunization; HCV; Hydrophobicity; Proteasome; Ubiquitin; Vaccine

Indexed keywords

CD8 ANTIGEN; CORE PROTEIN; HEPATITIS C VACCINE; PROTEASOME;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; ENDOPLASMIC RETICULUM; FEMALE; GENE DELETION; GENETIC CONSERVATION; GENOME ANALYSIS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNE RESPONSE; MAMMAL CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMID; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS GENOME;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HELA CELLS; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIGENS; HUMANS; HYDROPHOBICITY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; VACCINES, DNA; VIRAL CORE PROTEINS;

ANIMALIA; HEPATITIS C VIRUS; MAMMALIA;

EID: 30344484261     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.09.005     Document Type: Article

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