In vitro dual effect of arsenic trioxide on hemopoiesis: Inhibition of erythropoiesis and stimulation of megakaryocytic maturation

Blood Cells, Molecules, and Diseases

Volumn 36, Issue 1, 2006, Pages 59-76

  Saulle, Ernestina ^a   Riccioni, Roberta ^a   Pelosi, Elvira ^a   Stafness, Marit ^a   Mariani, Gualtiero ^a   De Tuglie, Giampiero ^a   Peschle, Cesare ^a   Testa, Ugo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Arsenic; Erythropoiesis; Hemopoiesis; Megakaryocytes; Transcription factors

Indexed keywords

ARSENIC TRIOXIDE; GLYCOPHORIN A; PROTEIN BCL XL; STAT5 PROTEIN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG INHIBITION; ERYTHROPOIESIS; GENE EXPRESSION; GENE TARGETING; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; PRIORITY JOURNAL; STEM CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; BCL-X PROTEIN; CELL DIFFERENTIATION; CELL SURVIVAL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GLYCOPHORIN; HEMATOPOIETIC STEM CELLS; HUMANS; K562 CELLS; MAP KINASE SIGNALING SYSTEM; MEGAKARYOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OXIDES; TRANSCRIPTION FACTORS;

EID: 30344482583     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2005.10.005     Document Type: Article

References (53)

1. H.D. Sun, L. Ma, X.-C. Hu, T.-D. Zhang, and I. Ai-Lin Treated 32 cases of acute promyelocytic leukemia Chin. J. Integr. Chin. West. Med. 12 1992 170 172
2. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients Blood 89 1997 3354 3360
3. C. Niu, H. Yan, H.P. Sun, J.X. Liu, Gu.Q. Cao, S. Waxman, Z. Chen, S.J. Chen, Z.X. Shen, and Z.Y. Wang Treatment of the novo and relapsed acute promyelocytic leukemia patients with arsenic trioxide Blood 92 Suppl. 1 1998 678
4. C. Niu, H. Yan, T. Yu, H.P. Sun, J.-X. Liu, X.S. Li, W. Wu, F.Q. Zhang, Y. Chen, L. Zhou, J.-M. Li, X.Y. Zeng, R.R. Ou Yang, M.-M. Yuan, M.-Y. Ren, F.Y. Gu, Q. Cao, B.-W. Gu, X.Y. Su, G.-Q. Chen, S.-M. Xiong, T.D. Zhang, S. Waxman, Z.Y. Wang, Z. Chen, J. Hu, Z.X. Shen, and S.J. Chen Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients Blood 94 1999 3315 3324
5. S.L. Soignet, P. Maslak, Z.-G. Wang, S. Jhanwar, E. Calleja, L.J. Dardashti, D. Corso, A. DeBlasio, J. Gabrilove, D.A. Scheinberg, P.P. Pandolfi, and R.P. Warrell Jr. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide N. Engl. J. Med. 339 1998 1341 1348
6. S.L. Soignet, S.R. Frankel, D. Douer, M.S. Tallman, H. Kantarjian, E. Calleja, R.M. Stone, M. Kalaycio, D.A. Scheinberg, P. Steinherz, E.L. Sievers, S. Coutre', S. Dahlberg, R. Ellison, and R.P. Warrell Jr. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia J. Clin. Oncol. 19 2001 3852 3860
7. 3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia Proc. Natl. Acad Sci. U. S. A. 101 2004 5328 5335
8. D. Douer, and M.S. Tallman Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies J. Clin. Oncol. 23 2005 2396 2410
9. W.H. Miller, H.M. Schipper, J.S. Lee, J. Singer, and S. Waxman Mechanisms of action of arsenic trioxide Cancer Res. 62 2002 3893 3903
10. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RARα/PML proteins Blood 88 1996 1052 1061
11. W. Shao, M. Fanelli, F. Ferrara, R. Riccioni, A. Rosenauer, K. Davison, W.W. Lamph, S. Waxman, P.G. Pelicci, F. Lo Coco, G. Avvisati, U. Testa, C. Peschle, C. Gambacorti-Passerini, C. Nervi, and W.H. Miller Jr. Arsenic trioxide as an inducer of apoptosis and loss of PML/RARα protein in acute promyelocytic leukemia cells J. Natl. Cancer Inst. 90 1998 124 133
12. J. Zhu, M.H. Koken, F. Quignon, M.K. Chelbi-Alix, L. Degos, Z.Y. Wang, Z. Chen, and H. de The' Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia Proc. Natl. Acad. Sci. U. S. A. 94 1997 3978 3983
13. C. Perkins, N. Caryn, L. Kim, Guofu Fang, N. Kapil, and L. Bhalla Arsenic induces apoptosis of multidrug-resistant human myeloid leukemic cells that express Bcr-abl or overexpress MDR, MRP, Bcl-2, or Bcl-Xl Blood 95 2000 1014 1021
14. G.J. Roboz, S. Dias, G. Lam, W.J. Lane, S.L. Soignet, R.P. Warrell Jr., and S. Rafii Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis Blood 96 2000 1525 1531
15. P. La Rosée, K. Johnson, M.E. O'Dwyer, and B.J. Druker In vitro studies of the combination of imatinib mesylate (Gleevec) and arsenic trioxide (Trisenox) in chronic myelogenous leukemia Exp. Hematol. 30 2000 729 737
16. P. La Rosèe, K. Johnson, A.S. Corbin, E.P. Stoffregen, E.M. Moseson, S. Willis, M. Mauro, J.V. Melo, M.W. Deininger, and B.J. Druker In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines Blood 103 2004 208 217
17. M. Lu, J. Levin, E. Sulpice, A. Sequeira-Le Grand, M. Alemany, J.P. Caen, and Z.C. Han Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines Exp. Hematol. 27 1999 845 852
18. 3) on human megakaryocytic leukemia cell lines with a comparison to the effect on other cell lineages Leuk. Lymphoma 38 2000 151 163
19. D.D. Westhoff, R.J. Samaha, and A. Barnes Jr. Arsenic intoxication as a cause of megaloblastic anemia Blood 45 1975 241 246
20. J.R. Feussner, J.D. Shelburne, S. Bredehoeft, and H.J. Choen Arsenic-induced bone marrow toxicity: ultrastructural and electron-probe analysis Blood 53 1979 820 827
21. J. Dai, R.S. Weinberg, S. Waxman, and Y. Jing Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system Blood 93 1999 268 277
22. N.M. Sposi, L.I. Zon, A. Carè, M. Valtieri, U. Testa, M. Gabbianelli, G. Mariani, L. Bottero, C. Mather, S.H. Orkin, and C. Peschle Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors Proc. Natl. Acad. Sci. U. S. A. 89 1992 6353 6357
23. R. Guerriero, U. Testa, M. Gabbianelli, G. Mattia, E. Montesoro, G. Macioce, A. Pace, B. Ziegler, H.J. Hassan, and C. Peschle Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture Blood 86 1995 3336 3725
24. J.F. Buckman, H. Hernandez, G.J. Kress, T.V. Votyakova, S. Pal, and I.J. Reynolda MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants J. Neurosci. Methods 104 2001 165 176
25. I. Nicoletti, G. Migliorati, M.C. Pagliacci, F. Grignani, and C. Riccardi A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry J. Immunol. Methods 139 1991 271 279
26. A. Tabilio, J.P. Rosa, U. Testa, N. Kieffer, A.T. Nurden, M.C. Del Canizo, J. Breton-Gorius, and W. Vainchenker Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL) EMBO J. 3 1995 453 459
27. + cells are correlated with different levels of platelet release Blood 99 2002 888 897
28. 3 enhances selective cytotoxic effect of STI-571 against Brc-Abl-positive acute leukemia cells Leukemia 15 2001 772 778
29. P. Lunghi, A. Costanzo, M. Levrero, and A. Bonati Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53 AIP1 apoptotic pathway in leukemia cells Blood 104 2004 519 525
30. R. De Maria, A. Zeuner, A. Eramo, C. Domenichelli, D. Bonci, F. Grignani, S.M. Srinivasula, E.S. Alnemri, U. Testa, and C. Peschle Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1 Nature 401 1999 489 493
31. A. Zeuner, A. Eramo, U. Testa, N. Felli, E. Pelosi, G. Mariani, S.M. Srinivasula, E.S. Alnemri, G. Condorelli, C. Peschle, and R. De Maria Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1 Cell Death Differ. 10 2003 905 913
32. H.Y. Cheng, P. Li, M. David, T.E. Smithgall, L. Feng, and M.W. Lieberman Arsenic inhibition of the JAK-STAT pathway Oncogene 23 2004 3603 3612
33. Y. Qian, V. Castranova, and X. Shi New perspectives in arsenic-induced cell signal transduction J. Inorg. Biochem. 96 2003 271 278
34. J.A. Ribeil, Y. Zermati, J. Kersual, M. Dussiot, F. Audat, C. Pouzet, F. Valensi, B. Varet, E. Solary, C. Garrido, and O. Hermine Hsp70 is a new major regulator of erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1 Annual Meeting of American Society of Hematology 2004 Abstr n. 581
35. U. Testa Apoptotic mechanisms in the control of erythropoiesis Leukemia 18 2004 1176 1199
36. J.L. Spivak The anaemia of cancer: death by a thousand cuts Nat. Rev., Cancer 5 2005 543 555
37. - mice due to decreased survival of early erythroblasts Blood 98 2001 3261 3273
38. J.J. Schuringa, K.Y. Chung, G. Morrone, and M.A.S. Moore Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation J. Exp. Med. 200 2004 623 635
39. V. Moucadel, and S.N. Constantinescu Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors J. Biol. Chem. 280 2005 13364 13374
40. C. Scholz, T. Wieder, L. Starck, F. Essmann, K. Schulze-Osthoff, B. Doeken, and P.T. Daniel Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway Oncogene 24 2005 1904 1913
41. C. Scholz, A. Richter, M. Lehmann, K. Schulze-Osthoff, B. Dorken, and P.T. Daniel Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway Oncogene 24 2005 7031 7042
42. Y.H. Kim, E.J. Park, S.T. Han, J.W. Park, and T.K. Kwon Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells Life Sci. 77 2005 2783 2793
43. J.G. Drachman, P. Rojnuckarin, and K. Kaushansky Thrombopoietin signal transduction: studies from cell lines and primary cells Methods 17 1999 238 249
44. S. Fichelson, J.M. Freyssinier, F. Picard, M. Fontenay-Roupie, M. Guesnu, M. Cherai, S. Gisselbrecht, and F. Porteu Megakaryocyte growth and development-factor induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hemopoietic progenitors Blood 94 1999 1601 1613
45. P. Rojnuckarin, J.G. Dracham, and K. Kaushansky Thrombopoietin-induced activation of the MAPK pathway in normal megakaryocytes: roles in endomitosis Blood 94 1999 1273 1282
46. A.S. Melemed, J.W. Ryder, and T.A. Vik Activation of the mitogen-activated protein kinase pathway is involved in and is sufficient for megakaryocytic differentiation of CMK cells Blood 90 1997 3452 3470
47. A.M. Whalen, S.C. Galasinki, P.S. Shapiro, T.S. Nahreini, and N.G. Ann Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase Mol. Cell. Biol. 17 1997 1947 1958
48. T. Smervaille, D.C. Linch, and A. Khwaja Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors Br. J. Haematol. 120 2003 876 886
49. P. Secchiero, E. Melloni, M. Heikinheimo, S. Mannisto, R. Di Pietro, A. Iacone, and G. Zauli TRAIL regulates normal erythroid maturation through an ERK-dependent pathway Blood 103 2004 517 522
50. Y. Zhang, and H.F. Lodish Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors Blood 104 2004 1679 1687
51. P. Ikonomi, C.E. Rivera, M. Riordan, G. Washington, A.N. Schechter, and C.T. Noguchi Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation Exp. Hematol. 28 2000 1423 1431
52. A.N. Chang, A.B. Cantor, Y. Fujiwara, M.B. Lodish, S. Droho, J.D. Crispino, and S.H. Orkin GATA-factor dependence of the multiple zinc-finger protein FOG-1 for its essential role in megakaryopoiesis Proc. Natl. Acad. Sci. U. S. A. 99 2002 9237 9242
53. K. Shinjo, A. Takeshita, N. Sahara, M. Kobayashi, S. Nakamura, K. Shigeno, K. Naito, M. Maekawa, K. Ohnishi, and R. Ohno Delayed recovery of normal hematopoiesis in arsenic trioxide treatment of acute promyelocytic leukaemia: a comparison to all-trans retinoic acid treatment Int. Med. 44 2005 814 828