Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 4, 2006, Pages 1229-1235

  Choi, Suk June ^a   Park, Hyen Joo ^a   Lee, Sang Kook ^a   Kim, Sang Woong ^b   Han, Gyoonhee ^c   Choo, Hea Young Park ^a  

^a Ewha Womans University   (South Korea)

^b Leadgenex Inc Venture Town Dasan   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Benzothiazoles; Cytotoxicity; Solid phase synthesis; Topoisomerase II inhibitory activity

Indexed keywords

2 (2 (DIFLUOROMETHYLTHIO)PHENYL)BENZO[D]THIAZOLE; 2 (2 (ETHYLTHIO)PYRIDIN 3 YL)BENZO[D]THIAZOLE; 2 (2 CHLORO 4 NITROPHENYL)BENZO[D]THIAZOLE; 2 (2 CHLORO 5 NITROPHENYL)BENZO[D]THIAZOLE; 2 (2 CHLOROSTYRYL)BENZO[D]THIAZOLE; 2 (2 ETHOXYPHENYL)BENZO[D]THIAZOLE; 2 (2 FLUORO 5 (TRIFLUOROMETHYL)PHENYL)BENZO[D]THIAZOLE; 2 (2,6 DIMETHOXYPHENYL)BENZO[D]THIAZOLE; 2 (3 (CHLOROMETHYL)PHENYL)BENZO[D]THIAZOLE; 2 (3 (DIFLUOROMETHYLTHIO)PHENYL)BENZO[D]THIAZOLE; 2 (3 (TRIFLUOROMETHOXY)PHENYL)BENZO[D]THIAZOLE; 2 (3,4 DICHLOROPHENYL)BENZO[D]THIAZOLE; 2 (3,4 DIMETHOXYPHENYL)BENZO[D]THIAZOLE; 2 (3,4,5 TRIMETHOXYPHENYL)BENZO[D]THIAZOLE; 2 (3,5 DICHLOROPHENYL)BENZO[D]THIAZOLE; 2 (4 HEPTYLPHENYL)BENZO[D]THIAZOLE; 2 (4 METHYL 3 NITROPHENYL)BENZO[D]THIAZOLE; 2 (4 NITROPHENYL)BENZO[D]THIAZOLE; 2 (4 TERT BETYLPHENYL)BENZO[D]THIAZOLE; 2 4 TOLYLBENZO[D]THIAZOLE; 3 (BENZO[D]THIAZOL 2 YL) 4 CHLOROBENZENAMINE; 4 (BENZO[D]THIAZOL 2 YL) 3 CHLOROBENZENAMINE; 4 (BENZO[D]THIAZOL 2 YL) N,N DIMETHYLBENZENAMINE; 4 (BENZO[D]THIAZOL 2 YL)BENZONITRILE; 5 (BENZO[D]THIAZOL 2 YL) 2 METHYLBENZENAMINE; BENZOTHIAZOLE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ELLIPTICINE; ETOPOSIDE; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; SOLID PHASE SYNTHESIS; TUMOR CELL LINE;

BENZOTHIAZOLES; CATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 30344440109     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.051     Document Type: Article

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