7-Oxanorbornane and norbornane mimics of a distorted β-D- mannopyranoside: Synthesis and evaluation as β-mannosidase inhibitors

Helvetica Chimica Acta

Volumn 88, Issue 12, 2005, Pages 3151-3173

  Buser, Stephan ^a   Vasella, Andrea ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; ESTERIFICATION; PH EFFECTS; SYNTHESIS (CHEMICAL);

ANHYDRIDE; METHANOLYSIS; SULFONYL ACRYLATE 9;

AROMATIC HYDROCARBONS;

1 (AMINOMETHYL) 5 (HYDROXYMETHYL) 7 OXABICYCLO[2.2.1]HEPTANE 2,3 DIOL; 1 (BENZYLAMINO) 5 (HYDROXYMETHYL)BICYCLO[2.2.1]HEPTANE 2,3 DIOL; 3 (PHENYLSULFONYL)PROP 2 ENOIC ACID; 3A,4,7,7A TETRAHYDRO 4,7 METHANO 1H INDENE 2,5 DICARBOXYLIC ACID; 4,4,12,12 TETRAMETHYL 9 (PHTHALIMIDOMETHYL) 3,5,11,13,15 PENTAOXYTETRACYCLO[7.5.1.0.0]TETRADECANE; 7 [(BENZYLOXY)METHYL] 6 (PHENYLSULFONYL) 3,10 DIOXATRICYCLO[5.2.1.0 1,5]DEC 8 EN 4 ONE; 7 OXANORBORNANE; 9 (AMINOMETHYL) 4,4,12,12 TETRAMETHYL 3,5,11,13,15 PENTAOXYTETRACYCLO[7.5.1.0.0]TETRADECANE; 9 [(BENZYLOXY)METHYL] 4,4 DIMETHYL 3,5,12 TRIOXATRICYCLO[5.4.0.1 1,9]DODECANE 10,11 DIOL; [2,3 DIHYDROXY 5 (HYDROXYMETHYL)BICYCLO[2.2.1]HEPT 1 YL](HYDROXY)AMMONIUM CHLORIDE; [4 [(BENZYLOXY)METHYL] 6 (HYDROXYMETHYL) 5 (PHENYLSULFONYL) 7 OXABICYCLO[2.2.1]HEPT 2 EN 1 YL]METHANOL; [5 [(BENZYLOXY)METHYL]FURAN 2 YL]METHYL 3 (PHENYLSULFONYL)PROP 2 ENOATE; BENZYL [8 (HYDROXYMETHYL) 4,4 DIMETHYL 3,5 DIOXATRICYCLO[5.2.1.0 2,6]DEC 1 YL]CARBAMATE; BETA DEXTRO MANNOPYRANOSIDE; BETA MANNOSIDASE; BETA MANNOSIDASE INHIBITOR; MANNOSIDASE INHIBITOR; METHYL 1 (ACETOXYMETHYL) 4,4 DIMETHYL 3,5,10 TRIOXATRICYCLO[5.2.1.0 2,6]DECANE 8 CARBOXYLATE; METHYL 1 (HYDROXYMETHYL) 4,4 DIMETHYL 3,5,10 TRIOXATRICYCLO[5.2.1.0 2,6]DECANE 8 CARBOXYLATE; METHYL 1 (PHTHALIMIDOMETHYL) 4,4 DIMETHYL 3,5,10 TRIOXATRICYCLO[5.2.1.0 2,6]DECANE 8 CARBOXYLATE; METHYL 1 [[(BENZYLOXY)CARBONYL]AMINO] 4,4 DIMETHYL 3,5 DIOXATRICYCLO[5.2.1.0 2,6]DECANE 8 CARBOXYLATE; METHYL 1 [[[(TERT BUTOXY)CARBONYL]AMINO]METHYL] 4,4 DIMETHYL 3,5,10 TRIOXATRICYCLO[5.2.1.0 2,6]DECANE 8 CARBOXYLATE; NORBORNANE DERIVATIVE; TERT BUTYL 3,5 DIOXO 4 OXATRICYCLO[5.2.1.0 2,6]DEC 8 ENE 1 CARBOXYLATE; TERT BUTYL [[8 (HYDROXYMETHYL) 4,4 DIMETHYL 3,5,10 TRIOXATRICYCLO[5.2.1.0 2,6]DEC 1 YL]METHYL]CARBAMATE; UNCLASSIFIED DRUG;

ALCOHOLYSIS; ARTICLE; CONFORMATION; CURTIUS REARRANGEMENT; DEACETYLATION; DECARBOXYLATION; DEGRADATION; DIELS ALDER REACTION; DIHYDROXYLATION; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; GEOMETRY; METHANOLYSIS; MITSUNOBU REACTION; PH; PRIORITY JOURNAL; REDUCTION;

EID: 30144442449     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200590255     Document Type: Article

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