A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node - Ablated, His bundle-paced dog

Journal of Pharmacological and Toxicological Methods

Volumn 53, Issue 1, 2006, Pages 1-10

  Nolan, Emily R ^a   Feng, Meihua Rose ^a   Koup, Jeffrey R ^a   Liu, Jing ^a   Turluck, Daniel ^a   Zhang, Yiqun ^a   Paulissen, Jerome B ^a   Olivier, N Bari ^b   Miller, Teresa ^a   Bailie, Marc B ^a  

^a PFIZER INC   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cardiovascular; Dog; His bundle pacing; Methods; Pharmacokinetic pharmacodynamic modeling; QT interval; Repolarization

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; CISAPRIDE; TERFENADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL HEART PACEMAKER; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; HEART ATRIOVENTRICULAR NODE; HEART PACING; HEART RATE; HEART REPOLARIZATION; HIS BUNDLE; IC 50; IN VIVO STUDY; MALE; NONHUMAN; QRS COMPLEX; QT PROLONGATION; RADIOFREQUENCY ABLATION; SENSITIVITY ANALYSIS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIOVENTRICULAR NODE; BUNDLE OF HIS; CARDIAC PACING, ARTIFICIAL; CATHETER ABLATION; CISAPRIDE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; GASTROINTESTINAL AGENTS; HISTAMINE H1 ANTAGONISTS; ION CHANNELS; LONG QT SYNDROME; MALE; MODELS, ANIMAL; MODELS, BIOLOGICAL; PIPERIDINES; PYRIDINES; TERFENADINE;

ANIMALIA; CANIS FAMILIARIS;

EID: 30144433108     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.02.003     Document Type: Article

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