Quantitative relationship between myocardial concentration of tacrolimus and QT prolongation in guinea pigs: Pharmacokinetic/pharmacodynamic model incorporating a site of adverse effect

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 6, 2001, Pages 533-554

  Minematsu, T ^a   Ohtani, H ^b   Yamada, Y ^a   Sawada, Y ^b   Sato, H ^c   Iga, T ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

Author keywords

Guinea pigs; Pharmacokinetic pharmacodynamic modeling; QT prolongation; Quinidine; Tacrolimus

Indexed keywords

TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARTMENT MODEL; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; GUINEA PIG; HEART MUSCLE; HEART VENTRICLE; LONG QT SYNDROME; MALE; NONHUMAN; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; QT INTERVAL;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRAVENOUS; LONG QT SYNDROME; MALE; MYOCARDIUM; TACROLIMUS; TISSUE DISTRIBUTION;

EID: 0035732087     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014460404352     Document Type: Article

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