Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in rat plasma

Drug Metabolism and Disposition

Volumn 34, Issue 1, 2006, Pages 84-93

  Brightman, F A ^a   Leahy, D E ^a   Searle, G E ^a   Thomas, S ^a  

^a CYPROTEX DISCOVERY LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; ERYTHROMYCIN; ORGANIC COMPOUND; PENTAZOCINE; PHENYTOIN; XENOBIOTIC AGENT; ACECAINIDE; ALPRAZOLAM; BIPERIDEN; BUDESONIDE; DEXAMETHASONE; DOFETILIDE; VERAPAMIL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; COST EFFECTIVENESS ANALYSIS; DRUG BLOOD LEVEL; IN VIVO STUDY; MAMMAL; MEASUREMENT; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; STANDARDIZATION; VALIDATION PROCESS; COMPUTER MODEL; HUMAN; IN VITRO STUDY; INTERMETHOD COMPARISON; RATING SCALE; RISK ASSESSMENT;

ALGORITHMS; ANIMALS; AREA UNDER CURVE; CLOZAPINE; ERYTHROMYCIN; HALF-LIFE; INJECTIONS, INTRAVENOUS; METABOLIC CLEARANCE RATE; MODELS, ANIMAL; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; PENTAZOCINE; PHENYTOIN; RATS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; XENOBIOTICS; ACECAINIDE; BIPERIDEN; DEXAMETHASONE; HUMANS; SPECIES SPECIFICITY; VERAPAMIL;

ANIMALIA; MAMMALIA;

EID: 29944443496     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.004804     Document Type: Article

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