Future prospects for toxicokinetics: Prediction of drug disposition and adverse effects in humans from in vitro measurements of drug metabolism, transport and binding

Journal of Toxicological Sciences

Volumn 23, Issue SUPPL. 4, 1998, Pages 647-652

  Sugiyama, Yuichi ^a   Ito, Kiyomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLXANTHINE; 1,3 DIMETHYLURIC ACID; 3 METHYLXANTHINE; ALPHA HYDROXYMETOPROLOL; ALPRAZOLAM; CYTOCHROME P450; DEALKYLVERAPAMIL; DIAZEPAM; FLUOROURACIL; IMIPRAMINE; LIDOCAINE; LOXTIDINE; MEXILETINE; NORVERAPAMIL; PHENACETIN; PLASMA PROTEIN; QUINIDINE; SORIVUDINE; TOLBUTAMIDE; WARFARIN;

AREA UNDER THE CURVE; CONFERENCE PAPER; DRUG BINDING; DRUG DISPOSITION; DRUG METABOLISM; DRUG TRANSPORT; HUMAN; KIDNEY CLEARANCE; NONHUMAN; PREDICTION; STEADY STATE;

EID: 0031762067     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.23.supplementiv_647     Document Type: Conference Paper

References (9)

1. Fuse, E., Kobayashi, T., Inaba, M. and Sugiyama, Y. (1995): Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in humans: integration of pharmacokinetics with pharmacodynamics and toxicodynamics.Cancer Treatment Reviews, 21, 133-157 (1995).
2. Ito, K., Asakura, A., Yamada, Y., Nakamura, K., Sawada, Y. and Iga, T.(1997): Prediction of the therapeutic dose for benzodiazepine anxiolytics based on receptor occupancy theory. Biopharm. Drug Dispos., 18, 293-303 (1997).
3. Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H. and Sugiyama, Y. (1996): Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics. Biopharm. Drug Disposit., 17,273-310(1996).
4. Iwatsubo, T., Hirota, N., Ooie, T, Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C.E., Tyson, C.A. and Sugiyama, Y.(1997): Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacol.Ther., 73, 147-171 (1997).
5. Iwatsubo, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C.E.,Tyson, C.A., Yokoi, T., Kamataki, T. and Sugiyama, Y.(1998): Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data using human liver microsomes and recombinant P-450 isozymes. J. Pharmacol. Exp. Ther. (in press):
6. Sugiyama, Y., Iwatsubo, T., Ueda, K. and Ito, K.(1996): Strategic proposals for avoiding toxic interactions with drugs for clinical use during development andafter marketing of a new drug pharmacokinetic consideration. J. Toxicol. Sci., 21,309-316(1996).
7. Sugiyama, Y. and Ooie, T.(1993): Prediction of pharmacokinetics based on in vitro data. In: Methods and Techniques for Pharmacokinetic Studies (Sugiyama, Y., ed.), pp. 87-108, Japanese Society for the Study of Xenobiotics, Tokyo (1993).
8. Suzuki, H., Nakai, D., Seita, T. and Sugiyama, Y.(1996): Design of drug delivery system for targeting based on pharmacokinetic consideration. "Pharmacokinetics in drug delivery systems" in "Advanced Drug Delivery Reviews" ed. by Y.Sugiyama, pp.335-357, Elsevier, 1996.
9. Yamazaki, M., Suzuki, H. and Sugiyama, Y.(1996): Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res., 13,497-513 (1996).