Size limits of thiocarbamibes accepted as substrates by human flavin- containing monooxygenase 1

Drug Metabolism and Disposition

Volumn 28, Issue 8, 2000, Pages 1003-1006

  Young Mi Kim, ^a   Ziegler, D M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBANILIDE; CHLORPROMAZINE; DIMETHYLANILINE MONOOXYGENASE; IMIPRAMINE; N,N DIMETHYLANILINE; ORPHENADRINE; PHENYLTHIOUREA; RANITIDINE; THIAMAZOLE; THIOUREA; DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING); OXYGENASE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; MICROSOME; NONHUMAN; PRIORITY JOURNAL; VIRUS RECOMBINANT; ANIMAL; ARMYWORM; CELL CULTURE; CHEMISTRY; CONFORMATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM;

ANIMALS; CELLS, CULTURED; HUMANS; METHIMAZOLE; MOLECULAR CONFORMATION; OXYGENASES; RECOMBINANT PROTEINS; SPODOPTERA; SUBSTRATE SPECIFICITY; THIOUREA; TRANSFECTION;

EID: 0034241811     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein
2. Differential development and tissue-specific regulation of expression of the genes encoding three members of the flavin containing monooxygenase family of man, FMO1, FMO3 and FMO4
3. Use of thiocarbamides as selective substrate probes for isoforms of flavin-containing monooxygenases
4. Nature of the 4a-flavin hydroperoxide of microsomal flavin-containing monooxygenase
5. Isoform specificity of trimethylamine N-oxygenation by human flavin- containing monooxygenase (FMO) and P450 enzymes: Selective catalysis by FMO3
6. Evidence for the presence of distinct flavin-containing monooxygenases in human tissues
7. Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver flavin adenine dinucleotide containing monooxygenase
8. Substrate specificities of rabbit lung and porcine liver flavin- containing monooxygenase: Differences due to substrate size
9. Multisubstrate flavin-containing monooxygenases: Application of mechanism to specificity