Transfer of some carboxylic acids in the olfactory system following intranasal administration

Journal of Drug Targeting

Volumn 7, Issue 2, 1999, Pages 131-142

  Eriksson, C ^a,c   Bergman, U ^a   Franzen A ^b   Sjoblom M ^b   Brittebo, E B ^b  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c IQVIA   (United States)

Author keywords

4 Chlorobenzoic acid; Benzoic acid; Nasal administration; Olfactory system; Phthalic acid; Salicylic acid

Indexed keywords

4 CHLOROBENZOIC ACID; BENZOIC ACID; CARBON 14; PHTHALIC ACID; SALICYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG METABOLISM; DRUG UPTAKE; FEMALE; GEL FILTRATION CHROMATOGRAPHY; INTRANASAL DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; NONHUMAN; NOSE MUCOSA; OLFACTORY BULB; OLFACTORY EPITHELIUM; OLFACTORY SYSTEM; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

EID: 0032726175     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869909085497     Document Type: Article

References (41)

1. Adams, D.R., Jones, A.M., Plopper, C.G., Serabjit-Singh, C.J. and Philpot, R.M. (1991) Distribution of cytochrome P-450 monooxygenase enzymes in the nasal mucosa of hamster and rat. Am. J. Anat., 190, 201-298.
2. Astic, L., Saucier, D., Coulon, P., Lafay, F. and Flamand, A. (1993) The CVS strain of rabies virus as transneuronal tracer in the olfactory system of mice. Brain Res., 619, 146-156.
3. Babic, N., Klupp, B., Brack, A., Mettenleiter, T.C., Ugolini, G. and Flamand, A. (1996) Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation. Virology, 219, 279-284.
4. Bogdanffy, M.S., Randall, H.W. and Morgan, K.T. (1987) Biochemical quantitation and histochemical localization of carboxylesterase in the nasal passages of the Fischer-344 rat and B6C3F1 mouse. Toxicol. Appl. Pharmacol., 88, 183-194.
5. Brandt, I. and Brittebo, E.B. (1989) The use of autoradiography as a tool to study xenobiotic metabolism. In Hutson, D.H., Caldwell, J. and Paulson, G.D. (Eds.), Intermediary Xenobiotic Metabolism in Animals: Methodology, Mechanisms and Significance (Taylor and Francis), pp. 295-314.
6. Brandt, I., Brittebo, E.B., Feil, V.J. and Bakke, J.E. (1990) Irreversible binding and toxicity of the herbicide dichlobenil (2,6-dichlorobenzonitrile) in the olfactory mucosa of mice. Toxicol. Appl. Phamacol., 103, 491-501.
7. Brewster, M.E., Anderson, W.R., Webb, A.I., Pablo, L.M., Meinsma, D., Moreno, D., Derendorf, H., Bodor, N. and Pop, E. (1997) Evaluation of a brain-targeting zidovudine chemical delivery system in dogs. Antimicrob. Agents Chemother., 41, 122-128.
8. Brittebo, E.B. (1988) Binding of cocaine in the liver, olfactory mucosa, eye, and fur of pigmented mice. Toxicol. Appl. Pharmacol., 96, 315-323.
9. Brittebo, E.B. and Eriksson, C. (1995) Taurine in the olfactory system: effects of the olfactory toxicant dichlobenil. Neurotoxicology, 16, 271-280.
10. Brittebo, E.B. (1997) Metabolism-dependent activation and toxicity of chemicals in nasal glands. Mutation Res., 380, 61-75.
11. Caldwell, J. (1995) The conjugation of carboxylic acid drugs and xenobiotics with amino acids. In Pacifici, G.M. and Fracchia, G.N. (Eds.), Advances in Drug Metabolism in Man (ECSC-EC-EAEC, Brussels, Luxembourg), pp. 497-512.
12. Dluzen, D.E. and Kefalas, G. (1996) The effects of intranasal infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) upon catecholamine concentrations within olfactory bulbs and corpus striatum of male mice. Brain Res., 741, 215-219.
13. Draghia, R., Caillaud, C., Manicom, R., Pavirani, A., Kahn, A. and Poenaru, L. (1995) Gene delivery into the central nervous system by nasal instillation in rats. Gene Ther., 2, 418-423.
14. Eriksson, C. and Brittebo, E.B. (1991) Metabolic activation of the herbicide dichlobenil in the olfactory mucosa. Chem. Biol. Interactions, 79, 165-177.
15. Esiri, M.M. and Tomlinson, A.H. (1984) Herpes simplex encephalitis. Immunohistological demonstration of spread of virus via olfactory and trigeminal pathways after infection of facial skin in mice. J. Neurol. Sci., 64, 213-217.
16. Frederick, C.B., Udinsky, J.R. and Finch, L. (1994) The regional hydrolysis of ethyl acrylate to acrylic acid in the rat nasal cavity. Toxicol. Lett., 70, 49-56.
17. Ghantous, H., Deneker, L., Gabrielsson, J., Danielsson, B.R.G. and Bergman, K. (1990) Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse. Pharmacol. Toxicol., 66, 87-92.
18. Gianutsos, G., Morrow, G.R. and Morris, J.B. (1997) Accumulation of manganese in rat brain following intranasal administration. Fundam. Appl. Toxicol., 37, 102-105.
19. Gozes, I., Bardea, A., Reshef, A., Zamostiano, R., Zhukovsky, S., Rubinraut, S., Fridkin, M. and Brenneman, D.E. (1996) Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide. Proc. Natl. Acad. Sci. USA, 93, 427-432.
20. Henriksson, J. and Tjälve, H. (1998) Uptake of inorganic mercury in the olfactory bulbs via olfactory pathways in rats. Environ. Res., 77, 130-140.
21. Hermens, W.T., Giger, R.J., Holtmaat, A.J., Dijkhuizen, P.A., Houweling, D.A. and Verhaagen, J. (1997) Transient gene transfer to neurons and glia: analysis of adenoviral vector performance in the CNS and PNS. J. Neurosci. Methods. 71, 85-98.
22. Huneycutt, B.S. , Plakhov, I.V., Shusterman, Z., Bartido, S.M., Huang, A., Reiss, C.S. and Aoki, C. (1994) Distribution of vesicular stomatitis virus proteins in the brains of BALB/c mice following intranasal inoculation: an immunohistochemical analysis. Brain Res., 635, 81-95.
23. Huwyler, J., Wu, D. and Pardridge, W.M. (1996) Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad. Sci. USA, 93, 14 164-14 169.
24. Klinger, W., Oelschlager, H., Karge, E. and Rothley, D. (1997) Interaction of chlormezanone with rat liver microsomes and its degradation. Eur. J. Drug Metab. Pharmacokinet., 22, 165-171.
25. Koeppel, C., Tenczer, J. and Wagemann, A. (1986) Metabolism of chlormezanone in man. Arzneim. Forsch. 36, 1116-1118.
26. Lewis, J.L., Nikula, K.J., Novak, R. and Dahl, A.R. (1994) Comparative localization of carboxylesterase in F344 rat. beagle dog, and human nasal tissue. Anat. Rec., 239, 55-64.
27. Mathison, S., Nagilla, R. and Kompella, U.B. (1998) Nasal route for direct delivery of solutes to the central nervous system: fact or fiction? J. Drug Targ., 5, 415-441.
28. Olson, M.J., Martin, J.L., LaRosa, A.C., Brady, A.N. and Pohl, L.R. (1993) Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats. J. Histochem. Cytochem., 41, 307-311.
29. Perlman, S., Barnett, E., and Jacobsen, G. (1993) Mouse hepatitis virus and herpes simplex virus move along different CNS pathways. Adv. Exp. Med. Biol., 342, 313-318.
30. 35S)taurine in peripheral layers of the olfactory bulb. Brain Res., 230, 378-383.
31. Shin, S.U., Friden, P., Moran, M., Olson, T., Kang, Y.S., Pardridge, W.M. and Morrison, S.L. (1995) Transferrin-antibody fusion proteins are effective in brain targeting. Proc. Natl. Acad. Sci. USA, 92, 2820-2824.
32. Stott, W.T. and McKenna, M.J. (1985) Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Fundam. Appl. Toxicol., 5, 399-404.
33. Thorne, R.G., Emory, C.R., Ala, T.A. and Frey, W.H. (1995) Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res., 692, 278-282.
34. Thornton-Manning, J.R. and Dahl, A.R. (1997) Metabolic capacity of nasal tissue interspaces comparisons of xenobiotic-metabolizing enzymes. Mut. Res., 380, 43-59.
35. Tjälve, H., Henriksson, J., Tallkvist, J., Larsson, B.S. and Lindquist. N.G. (1996) Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol. Toxicol., 79, 347-356.
36. Tomlinson, A.H. and Esiri, M.M. (1983) Herpes simplex encephalitis. Immunohistological demonstration of spread of virus via olfactory pathways in mice. J. Neural. Sci., 60, 473-484.
37. Ullberg, S. (1977) The technique of whole body autoradiography. Cryosectioning of large specimens. Science Tools, the LKB Instrument Journal, special issue, 2-29.
38. Wu, D., Yang, J. and Pardridge, W.M. (1997) Drug targeting of a peptide radiopharmaceutical through the primate blood brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J. Clin. Invest., 100, 1804-1812.
39. Wu, W.N., Weaner, L.E., Kalbron, J., O'Neill, P.J. and Grindel, J.M. (1980) The metabolism of zomepirac sodium: II. Isolation and identification of the urinary metabolites in rat, mouse, rhesus monkey and man. Drug Met. Dispos., 8, 349-352.
40. Young, J.T. (1981) Histopathological examination of the rat nasal cavity. Fund. Appl. Toxicol., 1, 309-312.
41. Zhao, H., Otaki, J.M. and Firestein, S. (1996) Adenovirus-mediated gene transfer in olfactory neurons in vivo. J. Neurobiol., 30, 521-530.