Pharmacogenetics of irinotecan: A promoter polymorphism of UGT1A1 gene and severe adverse reactions to irinotecan

Investigational New Drugs

Volumn 23, Issue 6, 2005, Pages 539-545

  Ando, Maki ^a   Hasegawa, Yoshinori ^a   Ando, Yuichi ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Genetic polymorphism; Irinotecan; Pharmacogenetics; UDP glucuronosyltransferase

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE 1A1; IRINOTECAN;

AREA UNDER THE CURVE; BLOODY DIARRHEA; DEHYDRATION; DISEASE SEVERITY; DRUG INDUCED DISEASE; DRUG METABOLISM; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME KINETICS; ETHNIC DIFFERENCE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HIGH RISK PATIENT; HUMAN; LEUKOPENIA; MALIGNANT NEOPLASTIC DISEASE; PHARMACOGENETICS; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; DIARRHEA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; GENOTYPE; GLUCURONOSYLTRANSFERASE; HUMANS; LEUKOPENIA; PHARMACOGENETICS; POLYMORPHISM, GENETIC; PRODRUGS; PROMOTER REGIONS (GENETICS);

EID: 29744447165     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-005-4022-6     Document Type: Review

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