How glucocorticoids control their own strength and the balance between pro- and anti-inflammatory mediators

European Journal of Immunology

Volumn 35, Issue 12, 2005, Pages 3396-3399

  Van Molle, Wim ^a   Libert, Claude ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Glucocorticoids; Inflammation; Macrophage migration inhibitory factor (MIF)

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; RECOMBINANT CYTOKINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR;

ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ASTHMA; AUTOIMMUNE DISEASE; CROHN DISEASE; CYTOKINE PRODUCTION; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE INDUCTION; GENE REPRESSION; HUMAN; LIGAND BINDING; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TARGETING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AUTOCRINE COMMUNICATION; GLUCOCORTICOIDS; HUMANS; INFLAMMATION MEDIATORS;

EID: 29744440890     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535556     Document Type: Note

References (22)

1. Newton, R., Molecular mechanisms of glucocorticoid action: what is important? Thorax 2000. 55: 603-613.
2. Tannirandorn, P. and Epstein, S., Drug-induced bone loss. Osteoporos. Int. 2000. 11: 637-659.
3. Prasad, G. V., Nash, M. M., McFarlane, P. A. and Zaltzman, J. S., Renal transplant recipient attitudes toward steroid use and steroid withdrawal. Clin. Transplant. 2003. 17: 135-139.
4. Adcock, I. M. and Lane, S. J., Corticosteroid-insensitive asthma: molecular mechanisms. J. Endocrinol. 2003. 178: 347-355.
5. Chadda, K. and Annane, D., The use of corticosteroids in severe sepsis and acute respiratory distress syndrome. Ann. Med. 2002. 34: 582-589.
6. Bloom, B. R. and Bennett, B., Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science 1966. 153: 80-82.
7. Bernhagen, J., Calandra, T., Mitchell, R. A., Martin, S. B., Tracey, K. J., Voelter, W., Manogue, K. R., Cerami, A. and Bucala, R., MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature 1993. 365: 756-759.
8. Calandra, T., Echtenacher, B., Roy, D. L., Pugin, J., Metz, C. N., Hultner, L., Heumann, D., Mannel, D., Bucala, R. and Glauser, M. P., Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat. Med. 2000. 6: 164-170.
9. Bozza, M., Satoskar, A. R., Lin, G., Lu, B., Humbles, A. A., Gerard, C. and David, J. R., Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J. Exp. Med. 1999. 189: 341-346.
10. Calandra, T., Spiegel, L. A., Metz, C. N. and Bucala, R., Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proc. Natl. Acad. Sci. USA 1998. 95: 11383-11388.
11. Juttner, S., Bernhagen, J., Metz, C. N., Rollinghoff, M., Bucala, R. and Gessner, A., Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha. J. Immunol. 1998. 161: 2383-2390.
12. Satoskar, A. R., Bozza, M., Rodriguez Sosa, M., Lin, G. and David, J. R., Migration-inhibitory factor gene-deficient mice are susceptible to cutaneous Leishmania major infection. Infect. Immun. 2001. 69: 906-911.
13. Calandra, T., Bernhagen, J., Metz, C. N., Spiegel, L. A., Bacher, M., Donnelly, T., Cerami, A. and Bucala, R., MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995. 377: 68-71.
14. Roger, T., Chanson, A-L., Knaup-Reymond, M. and Calandra, T., Macrophage migration inhibitory factor (MIF) promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1 Eur. J. Immunol. 2005. 35: DOI: 10.1002/eji.200535416
15. English, J., Pearson, G., Wilsbacher, J., Swantek, J., Karandikar, M., Xu, S. and Cobb, M. H., New insights into the control of MAP kinase pathways. Exp. Cell. Res. 1999. 253: 255-270.
16. Neininger, A., Kontoyiannis, D., Kotlyarov, A., Winzen, R., Eckert, R., Volk, H. D., Holtmann, H., Kollias, G. and Gaestel, M., MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J. Biol. Chem. 2002. 277: 3065-3068.
17. Clark, A. R., MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J. Endocrinol. 2003. 178: 5-12.
18. Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H. and Imai, K., Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation. Mol. Endocrinol. 2002. 16: 2382-2392.
19. Irusen, E., Matthews, J. G., Takahashi, A., Barnes, P. J., Chung, K. F. and Adcock, I. M., p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J. Allergy Clin. Immunol. 2002. 109: 649-657.
20. Li, L. B., Goleva, E., Hall, C. F., Ou, L. S. and Leung, D. Y., Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway. J. Allergy Clin. Immunol. 2004. 114: 1059-1069.
21. Van Molle, W., Sekikawa, K., Kollias, G. and Libert, C., The coordinated action of glucocorticoids and HSP70 prevent TNF-induced glucocorticoid receptor inactivation and lethality. J. Exp. Med. 2005 In press.
22. Lee, K. H., Lee, C. T., Kim, Y. W., Han, S. K., Shim, Y. S. and Yoo, C. G., Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1. J. Biol. Chem. 2005. 280: 13179-13186.