Increased radiosensitivity in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells

Radiation Research

Volumn 165, Issue 1, 2006, Pages 26-34

  Mothersill, C ^a   Seymour, R J ^a   Seymour, C B ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER THERAPY; CELL GROWTH; CELL STRAIN; CELL STRAIN HPV G; CELL STRAIN HT29; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; GAMMA IRRADIATION; GROWTH RATE; HUMAN; HUMAN CELL; IRRADIATION; MISMATCH REPAIR; MODULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; RAJI 10 CELL; RAJI CELL;

APOPTOSIS; BYSTANDER EFFECT; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CULTURE MEDIA; DNA REPAIR-DEFICIENCY DISORDERS; FIBROBLASTS; GAMMA RAYS; HUMANS; RADIATION TOLERANCE;

EID: 29644437158     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3488.1     Document Type: Article

References (48)

1. B. Marples, O. Greco, M. C. Joiner and S. D. Scott, Radiogenetic therapy: Strategies to overcome tumor resistance. Curr. Pharm. Des. 9, 2105-2112 (2003).
2. Z. Dai, Y. Huang and W. Sadee, Growth factor signaling and resistance to cancer chemotherapy. Curr. Top. Med. Chem. 4, 1347-1356 (2004).
3. W. M. Bonner, Phenomena leading to cell survival values which deviate from linear-quadratic models. Mutat. Res. 2, 33-39 (2004).
4. M. Schaffer, S. B. Schwarz, U. Kulka, M. Busch and E. Duhmke, Adaptive doses of irradiation - an approach to a new therapy concept for bladder cancer? Radiat. Environ. Biophys. 4, 271-276 (2004).
5. A. G. Pearce, T. M. Segura, A. C. Rintala, N. D. Rintala-Maki and H. Lee, The generation and characterization of a radiation-resistant model system to study radioresistance in human breast cancer cells. Radiat. Res. 156, 739-750 (2001).
6. C. Mothersill, R. J. Seymour and C. B. Seymour, Bystander effects in repair-deficient cell lines. Radiat. Res. 161, 256-263 (2004).
7. H. Nagasawa, L. Huo and J. B. Little, Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int. J. Radiat. Biol. 79, 35-41 (2003).
8. J. B. Little, H. Nagasawa, G. C. Li and D. J. Chen, Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat. Res. 159, 262-267 (2003).
9. C. Mothersill and C. B. Seymour, Bystander and delayed effects after fractionated radiation exposure. Radiat. Res. 158, 626-633 (2002).
10. P. Maguire, C. Mothersill, C. B. Seymour and F. M. Lyng, Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiat. Res. 163, 384-390 (2005).
11. W. F. Morgan, Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159, 581-596 (2003).
12. W. F. Morgan, Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567-580 (2003).
13. P. J. Coates, S. A. Lorimore and E. G. Wright, Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutat. Res. 568, 5-20 (2004).
14. C. Mothersill and C. B. Seymour, Radiation-induced bystander effects - implications for cancer. Nat. Rev. Cancer 4, 158-164 (2004).
15. R. Hampson, O. Humbert, P. Macpherson, G. Aquilina and P. Karran, Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells. J. Biol Chem. 7, 28596-28606 (1997).
16. L. Pirisi, K. E. Creek, J. Doniger and J. A. DiPaolo, Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 9, 1573-1579 (1988).
17. C. Mothersill, D. Rea, E. G. Wright, S. A. Lorimore, D. Murphy, C. B. Seymour and K. O'Malley, Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium. Carcinogenesis 22, 1465-1471 (2001).
18. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000).
19. S. von Kleist, E. Chany, R Burtin, M. King and J. Fogh, Immunohistology of the antigenic pattern of a continuous cell line from a human colon tumor. J. Natl. Cancer Inst. 55, 555-560 (1975).
20. C. Mothersill, C. B. Seymour and M. C. Joiner, Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiat. Res. 157, 526-532 (2002).
21. T. T. Puck and P. I. Marcus, Action of x-rays on mammalian cells. J. Exp. Med. 103, 653-666 (1956).
22. L. Geng and C. S. Potten, Changes after irradiation in the number of mitotic cells and apoptotic fragments in growing mouse hair follicles and in the width of their hairs. Radiat. Res. 123, 75-81 (1990).
23. C. E. Mothersill, K. J. O'Malley, D. M. Murphy, C. B. Seymour, S. A. Lorimore and E. G. Wright, Identification and characterization of three subtypes of radiation response in normal human urothelial cultures exposed to ionizing radiation. Carcinogenesis 20, 2273-2278 (1999).
24. M. C. Joiner, P. Lambin and B. Marples, Adaptive response and induced resistance. C. R. Acad. Sci. III 322, 167-175 (1999).
25. C. Mothersill and C. B. Seymour, Recovery of the radiation survival-curve shoulder in CHO-KI, XRS-5 and revenant XRS-5 populations. Mutat. Res. 285, 259-266 (1993).
26. C. B. Seymour and C. Mothersill, Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiat. Oncol. Investig. 5, 106-110 (1997).
27. S. Nagar, L. E. Smith and W. F. Morgan, Mechanisms of cell death associated with death-inducing factors from genomically unstable cell lines. Mutagenesis 18, 549-560 (2003).
28. A. S. Balajee, B. Ponnaiya, R. Baskar and C. R. Geard, Induction of replication protein A in bystander cells. Radiat. Res. 162, 677-686 (2004).
29. C. Shao, M. Folkard, B. D. Michael and K. M. Prise, Targeted cytoplasmic irradiation induces bystander responses. Proc. Natl. Acad. Sci. USA 101, 13495-13500 (2004).
30. R. E. Rugo and R. H. Schiestl, Increases in oxidative stress in the progeny of X-irradiated cells. Radiat. Res. 162, 416-425 (2004).
31. O. V. Belyakov, M. Folkard, C. Mothersill, K. M. Prise and B. D. Michael, Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiat. Prot. Dosim. 99, 249-251 (2002).
32. F. M. Lyng, C. B. Seymour and C. Mothersill, Early events in the apoptotic cascade initiated in cells treated with medium from the progeny of irradiated cells. Radiat. Prot. Dosim. 99, 169-172 (2002).
33. K. M. Prise, M. Folkard and B. D. Michael, A review of the bystander effect and its implications for low-dose exposure. Radiat. Prot. Dosim. 104, 347-355 (2003).
34. W. F. Morgan, Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation? Oncogene 22, 7094-7099 (2003).
35. C. Mothersill and C. Seymour, Radiation-induced bystander effects and adaptive responses - the Yin and Yang of low dose radiobiology? Mutat. Res. 568, 121-128 (2004).
36. P. J. Coates, S. A. Lorimore and E. G. Wright, Cell and tissue responses to genotoxic stress. J. Pathol. 205, 221-235 (2005).
37. K. M. Prise, M. Folkard and B. D. Michael, A review of the bystander effect and its implications for low-dose exposure. Radiat. Prot. Dosim. 104, 347-355 (2003).
38. T. K. Hei, R. Persaud, H. Zhou and M. Suzuki, Genotoxicity in the eyes of bystander cells. Mutat. Res. 568, 111-120 (2004).
39. M. Suzuki, H. Zhou, C. R. Geard and T. K. Hei, Effect of medium on chromatin damage in bystander mammalian cells. Radiat. Res. 162, 264-269 (2004).
40. P. Matzinger, An Innate sense of danger. Ann. NY Acad. Sci. 961, 341-342 (2002).
41. P. Matzinger, The danger model: A renewed sense of self. Science 296, 301-305 (2002).
42. S-Y. Seong and P. Matzinger, Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4, 469-478 (2004).
43. C. Y. Liu, P. I. Chuang, C. L. Chou, S. M. Lin, H. C. Chen, P. Chou, Y H. Liu, C. T. Yu, C. H. Wang and H. P. Kuo, Cytoprotective response of A1, a Bcl-2 homologue expressed in mature human neutrophils and promyelocytic HL-60 cells, to oxidant stress-induced cell death. J. Biomed. Sci. 11, 214-227 (2004).
44. 67Cu-2IT-BAT-Lym-1 radioimmunotherapy. Cancer Biother. Radiopharm. 16, 213-225 (2001).
45. X. S. Xu, L. Narayanan, B. Dunklee, R. M. Liskay and P. M. Glazer, Hypermutability to ionizing radiation in mismatch repair-deficient, Pms2 knockout mice. Cancer Res. 61, 3775-3780 (2001).
46. J. A. Fritzell, L. Narayanan, S. M. Baker, C. E. Bronner, S. E. Andrew, T. A. Prolla, A. Bradley, F. R. Jirik, R. M. Liskay and P. M. Glazer, Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res. 57, 5143-5147 (1997).
47. C. Mothersill, F. Lyng, C. Seymour, P. Maguire, S. Lorimore and E. Wright, Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in vivo. Radiat Res. 163, 391-399 (2005).
48. A. Rodriguez and E. L. Alpen, Feeder cells and cell survival in spheroids and monolayers. Int. J. Radiat. Biol. 41, 111-117 (1982).