Identification and characterization of three subtypes of radiation response in normal human urothelial cultures exposed to ionizing radiation

Carcinogenesis

Volumn 20, Issue 12, 1999, Pages 2273-2278

  Mothersill, Carmel E ^a   O'Malley, Kiaran J ^b   Murphy, Dennis M ^b   Seymour, Colin B ^a   Lorimore, Sally A ^c   Wright, Eric G ^c,d  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^b BEAUMONT HOSPITAL   (Ireland)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENETIC STABILITY; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION RESPONSE; STRAIN DIFFERENCE; UROTHELIUM;

EID: 0033398524     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.12.2273     Document Type: Article

References (26)

1. Committee on the Biological Effects of Ionising Radiation (1990) Effects of Exposure to Low Levels of Ionising Radiations. National Academy of Sciences/National Research Council, Washington, DC.
2. Boice, J.D. Jr, Land, C.E., Shore, R.E., Norman, J.E. and Tokunaga, M. (1979) Risk of breast cancer following low-dose exposure. Radiology, 131, 589-597.
3. Hall, E. (1994) Radiobiology for the Radiologist, 4th Edn. Lippencott, Philadelphia, PA.
4. Knudson, A.G. (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA, 68, 820-823.
5. 0) T-lymphocyte lines and fibroblasts from normal donors, from ataxiatelangiectasia patients and from ataxia-telangiectasia heterozygotes. Int. J. Radiat. Biol., 54, 929-943.
6. Zhan, Q., Bae, I., Fornace, A.J. Jr and Craig, R.W. (1997) Induction of bcl-2 family member, Mcl1 as an early response to DNA damage. Oncogene, 14, 1031-1039.
7. Sheikh, M.S., Burns, T.F., Huang, Y., Wu, G.S., Amundson, S., Brooks, K.S., Fornace, A.J. Jr and El-Deiry, W.S. (1998) p53 dependent and independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and TNFα. Cancer Res., 58, 1593-1598.
8. Kadhim, M., Macdonald, D.A., Goodhead, S.A., Lorimore, S.A., Marsden, S.J. and Wright, E.G. (1992) Tramsmission of chromosomal instability after plutonium alpha-particle irradiation. Nature, 355, 738-740.
9. Kadhim, M.A., Lorimore, S.A., Townsend, K.M.S., Goodhead, D.T., Buckle, V.J. and Wright, E.G. (1995) Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int. J. Radiat. Biol., 57, 287-293.
10. Morgan, W.F., Day, J.P., Kaplan, M.I., McGee, E.M. and Limoli, C.L. (1996) Genomic instability induced by ionising radiation. Radiat. Res., 146, 247-258.
11. Lyng, F., O'Reilly, S., Cottell, D., Seymour, C.B. and Mothersill, C. (1996) Persistent expression of morphological abnormalities in the distant progeny of irradiated cells. Radiat. Environ. Biophys., 35, 273-283.
12. Mendonca, M.S., Temples, T.M., Farrington, D.L. and Bloch, C. (1998) Evidence for a role of delayed death and genomic instability in radiation-induced neoplastic transformation of human hybrid cells. Int. J. Radiat. Biol., 74, 755-764.
13. Little, J.B. (1998) Radiation-induced genomic instability. Int. J. Radiat Biol., 74, 663-671.
14. Ullrich, R.L. and Ponnaiya, B. (1998) Radiation-induced instability and its relation to radiation carcinogenesis. Int. J. Radiat. Biol., 74, 747-754.
15. Mothersill, C. and Seymour, C.B. (1998) Delayed death and genomic instability after low dose irradiation: implications for protection [Invited Commentary]. Mutagenesis, 13, 421-426.
16. Harney, J., Mothersill, C., Seymour, C. and Murphy, D. (1995) Interrelationship between p53, CMYC and BCL-2 oncoprotein expression in cultures of normal human urothelium exposed to cobalt 60 gamma rays and n-nitrosodiethanolamine. Cancer Epidemiol. Biomarkers Prev., 4, 617-625.
17. Mothersill, C., Harney, J., Lyng, F., Cottell, D. and Seymour, C.B. (1995) Primary explants of normal human uroepithelium show an unusual response to low doses of cobalt 60 gamma rays. Radiat. Res., 142, 181-187.
18. Mothersill, C., O'Malley, K., Harney, J., Lyng, F., Murphy, D. and Seymour, C. (1997) Further investigations of the response of human uroepithelium to low doses of cobalt 60 gamma radiation. Radiat. Res., 147, 156-165.
19. Watson, G.E., Lorimore, S.A., Clutton, S.M., Kadhim, M.A. and Wright, E.G. (1997) Genetic factors influencing α-particle-induced chromosomal instability. Int. J. Radiat. Biol., 71, 497-503.
20. Mothersill, C., O'Malley, K., Murhpy, D., Lynch, T., Payne, S., Seymour, C. and Harney, J. (1997) P53 protein expression and increased SSCP mobility shifts in the p53 gene in normal urothelium cultured from smokers. Carcinogenesis, 18, 1241-1245.
21. Kroemer, G. (1997) The proto-oncogene bcl-2 and its role in regulating apoptosis. Nature Med., 3, 614-620.
22. Withers, H.R., Taylor, J.M.G. and Maciejewski, B. (1988) The hazard of accelerated tumour clonogen repopulation during radiotherapy. Acta Oncol., 27, 131-141.
23. Schofield, P.N. (1998) Impact of genomic imprinting on genomic instability and radiation-induced mutation. Int. J. Radiat. Biol., 74, 705-710.
24. Lord, B.I., Woolford, L.B., Wang, L., Stones, V.A., McDonald, D., Lorimore, S.A., Papworth, D., Wright, E.G. and Scott, D. (1998) Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239. Br. J. Cancer, 78, 301-311.
25. Lord, B.I., Woolford, L.B., Wang, L., Stones, V.A., McDonald, D., Lorimore, S.A., Wright, E.G. and Scott, D. (1998) Induction of lymphohaemopoietic malignancy: impact of preconception paternal irradiation. Int. J. Radiat. Biol., 74, 721-728.
26. Gardner, M.J., Snee, M.P., Hall, A.J., Powell, C.A., Downes, S. and Terrell, J.D. (1990) Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. Br. Med. J., 300, 423-429.