Wegener's granulomatosis: A view from the granulomatous side of the disease

Israel Medical Association Journal

Volumn 7, Issue 12, 2005, Pages 768-773

  Aries, Peer M ^a   Lamprecht, Peter ^a   Gross, Wolfgang Ludwig ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Granuloma; Localized; Orbita; Vasculitis; Wegener's granulomatosis

Indexed keywords

CD20 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; GAMMA INTERFERON; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL FEATURE; CYTOKINE PRODUCTION; GRANULOMATOUS INFLAMMATION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; NONHUMAN; RESPIRATORY TRACT DISEASE; TH1 CELL; TH2 CELL; VASCULITIS; WEGENER GRANULOMATOSIS;

CYTOKINES; HUMANS; MIDDLE AGED; T-LYMPHOCYTES; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 29544449940     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Jenne DE, Tschopp J, Lüdemann J, Utecht B, Gross WL. Wegener's autoantigen decoded. Nature 1990;346:520.
2. Bacon PA. The spectrum of Wegener's granulomatosis and disease relapse. N Engl J Med 2005;352:330-2.
3. Sneller MC. Granuloma formation, implications for the pathogensis of vasculitis. Cleveland Clin J Med 2002;69(Suppl 2):SII-40-2.
4. Fienberg R. A morphologic and immunohistologic study of the evolution of the necrotizing palisading granuloma of pathergic (Wegener's) granulomatosis. Semin Respir Med 1989;10:126-32.
5. Lamprecht P, Brühl H, Erdmann A, et al. Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clin Immunol 2003;108:1-7.
6. Müller A, Trabandt A, Glöckner-Hofmann K, et al. Localized Wegener's granulomatosis: predominance of CD26 and IFN-γ expression. J Pathol 2000;192:113-20.
7. Komocsi A, Lamprecht P, Csernok E, et al. Peripheral blood and granuloma CD4+CD28- T-cells are a major source of IFN-γ and TNF-α in Wegener's granulomatosis. Am J Pathol 2002;160:1717-24.
8. Lamprecht P. Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Clin Exp Immunol 2005;141:201-10.
9. Lang KS, Recher M, Junt T, et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 2005;11:138-45.
10. Zinkernagel RM, Hengartner H. Regulation of immune response by antigen. Science 2001;293:251-3.
11. Popa ER, Stegeman CA, Kallenberg CGM, Cohen Tervaert JW. Staphylococcus aureus and Wegener's granulomatosis. Arthritis Res 2002;4:77-9.
12. Moyron-Quiroz JE, Rangel-Moreno J, Kusser K, et al. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med 2004;10:927-34.
13. Ehlers S, Benini J, Held HD, Rock C, Alber G, Uhlig S. αβ TCR+ cells and IFNγ, but not iNOS are critical for granuloma necrosis in a mouse model for mycobacteria-induced pulmonary immunopathology. J Exp Med 2001;194:1847-59.
14. Braun MG, Csernok E, Gross WL, Muller-Hermelink HK. Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues. Am J Pathol 1991;139:831-8.
15. Zinkernagel RM. On 'reactivity' versus 'tolerance'. Immunol Cell Biol 2004;82:343-52.
16. Balding CE, Howie AJ, Drake-Lee AB, Savage CO. Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis. Clin Exp Immunol 2001;125:332-9.
17. Coulomb-L'Hermine A, Capron F, Zhou W, et al. Expression of the chemokine RANTES in pulmonary Wegener's granulomatosis. Hum Pathol 2001;32:320-6.
18. Moosig F, Csernok E, Wang G, Gross WL. Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol 1998;114:113-18.
19. Lamprecht P, Moosig F, Csernok E, et al. CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis. Thorax 2001;56:751-7.
20. Weyand CM, Fulbright JW, Goronzy JJ. Immunosenescence, autoimmunity, and rheumatoid arthritis. Exp Gerontol 2003;38:833-41.
21. Moosig F, Csernok E, Kumanovics G, Gross WL. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumor necrosis factor-alpha (TNF-alpha). Clin Exp Immunol 2000;122:499-503.
22. Voswinkel J, Müller A, Lamprecht P. Is PR3-ANCA formation initiated in Wegener's granulomatosis lesions? Ann N Y Acad Sci 2005;1050:1-8.
23. Weyand CM, Kurtin PJ, Goronzy JJ. Ectopic lymphoid organogenesis: a fast track for autoimmunity. Am J Pathol 200;159:787-93.
24. Carrington CB, Liebow AA. Limited forms of angiitis and granulomatosis of Wegener's type. Am J Med 1966;41:497-527.
25. Fienberg R. The protracted superficial phenomenon in pathergic (Wegener's) granulomatosis. Hum Pathol 1981;12:458-67.
26. Reinhold-Keller E, Beuge N, Latza U, et al. An interdisciplinary approach to the care of patients with Wegener's granulomatosis: long-term outcome in 155 patients. Arthritis Rheum 2000;43:1021-32.
27. Papadimitraki ED, Kyrmizakis DE, Kritikos I, Boumpas DT. Ear-nose-throat manifestations of autoimmune rheumatic diseases. Clin Exp Rheumatol 2004;22:485-94.
28. Perry SR, Rootman J, White VA. The clinical and pathologic constellation of Wegener granulomatosis of the orbit. Ophthalmology 1997;104:683-94.
29. Reinhold-Keller E, de Groot K, Holl-Ulrich K, et al. Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmatic antibodies (ANCA). A report of 3 cases and a review of the literature. Clin Exp Rheumatol 2001;19:541-9.
30. Murphy JM, Gomez-Anson B, Gillar JH, et al. Wegener granulomatosis: MR imaging findings in brain and meninges. Radiology 1999;213:794-9.
31. Roberts GA, Eren E, Sinclair H, et al. Two cases of Wegener's granulomatosis involving the pituitary. Clin Endocrinol 1995;42: 323-8.
32. Aries PM, Both M. Destructive eye lesions in Wegener's granulomatosis. N Engl J Med 2005;352:392.
33. Lebovics RS, Hoffmann GS, Leavitt RY, et al. The management of subglottic stenosis in patients with Wegener's granulomatosis. Laryngoscope 1992;102:1341-5.
34. Lohrmann C, Uhl M, Kotter E, Burger D, Ghanem N, Langer M. Pulmonary manifestations of Wegener granulomatosis: CT findings in 57 patients and review of the literature. Eur J Radiol 2005;53:471-7.
35. Papiis SA, Manoussakis MN, Drosos AA, Kontogiannis D, Constantopoulos SH, Moutsoupoulos HM. Imaging of thoracic Wegener's granulomatosis: the computed tomographic appearance. Am J Med 1992:93:529-36.
36. Travis WD, Hoffmann GS, Leavitt RY, Pass HI, Fauci AS. Surgical pathology of the lung in Wegener's granulomatosis. Review of 87 open lung biopsies from 67 patients. Am J Surg Pathol 1991;15:315-33.
37. Chegar BE, Kelley RT. Wegener's granulomatosis presenting as unilateral parotid enlargement. Larnygoscope 2004;114:1730-3.
38. Matsubayashi H, Seki T, Niki S, et al. Wegener's granulomatosis with onset of acute pancreatitis and rapid progress. Pancreatology 2001;1:263-6.
39. Huong DL, Papo T, Piette JC, et al. Urogenital manifestations of Wegener's granulomatosis. Medicine (Baltimore) 1995;74:152-61.