Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells

World Journal of Gastroenterology

Volumn 11, Issue 40, 2005, Pages 6312-6321

  Strup Perrot, Carine ^a   Vozenin Brotons, Marie Catherine ^a,b   Vandamme, Marie ^a   Linard, Christine ^a   Mathe, Denis ^b  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Cytokines; Ileum; Irradiation; Matrix metalloproteinases; T cells

Indexed keywords

CD8ALPHA ANTIGEN; CYTOKINE; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; PLASMIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; ILEUM; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; IONIZING RADIATION; MACROPHAGE; MALE; MESENCHYME CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION EXPOSURE; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TISSUE LEVEL; X IRRADIATION; ZYMOGRAPHY;

EID: 29544447137     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i40.6312     Document Type: Article

References (39)

1. Becciolini A, Balzi M, Potten CS. Radiation effects on proliferation and differentiation in the rat small intestine In. Potten CS, Hendry JH, eds. Radiation and Gut. Amsterdam: Elsevier 1995: 85-143
2. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001; 17: 463-516
3. Burger A, Loffler H, Bamberg M, Rodemann HP. Molecular and cellular basis of radiation fibrosis. Int J Radiat Biol 1998; 73: 401-408
4. Linard C, Ropenga A, Vozenin-Brotons MC, Chapel A, Mathe D. Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layer. Am J Physiol Gastrointest Liver Physiol 2003; 285: G556-565
5. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999; 274: 21491-21494
6. Pender SL, Salmela MT, Monteleone G, Schnapp D, McKenzie C, Spencer J, Fong S, Saarialho-Kere U, MacDonald TT. Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype. Am J Pathol 2000; 157: 1955-1962
7. Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002; 115: 3719-3727
8. Bailey CJ, Hembry RM, Alexander A, Irving ME, Grant ME, Shuttleworth CA. Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine. J Clin Pathol 1994; 47: 113-116
9. Baugh MD, Perry MJ, Hollander AP, Davies DR, Cross SS, Lobo AJ, Taylor CJ, Evans GS. Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 1999; 117: 814-822
10. Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JA, Pender SL. Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut 2000; 47: 57-62
11. Louis E, Ribbens C, Godon A, Franchimont D, De Groote D, Hardy N, Boniver J, Belaiche J, Malaise M. Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Clin Exp Immunol 2000; 120: 241-246
12. Saarialho-Kere UK, Vaalamo M, Puolakkainen P, Airola K, Parks WC, Karjalainen-Lindsberg ML. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am J Pathol 1996; 148: 519-526
13. Salmela MT, MacDonald TT, Black D, Irvine B, Zhuma T, Saarialho-Kere U, Pender SL. Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. Gut 2002; 51: 540-547
14. Pender SL, Tickle SP, Docherty AJ, Howie D, Wathen NC, MacDonald TT. A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 1997; 158: 1582-1590
15. Seifert WF, Wobbes T, Hoogenhout J, de Man BM, Hendriks T. Intra-operative irradiation prolongs the presence of matrix metalloproteinase activity in large bowel anastomoses of the rat. Radiat Res 1997; 147: 354-361
16. Hovdenak N, Wang J, Sung CC, Kelly T, Fajardo LF, Hauer-Jensen M. Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer. Int J Radiat Oncol Biol Phys 2002; 53: 919-927
17. Kumar A, Collins HM, Scholefield JH, Watson SA. Increased type-IV collagenase (MMP-2 and MMP-9) activity following preoperative radiotherapy in rectal cancer. Br J Cancer 2000; 82: 960-965
18. Kleiner DE, Stetler-Stevenson WG. Quantitative zymography: detection of picogram quantities of gelatinases. Anal Biochem 1994; 218: 325-329
19. Strup-Perrot C, Mathe D, Linard C, Violot D, Milliat F, Francois A, Bourhis J, Vozenin-Brotons MC. Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs and TIMPs in late radiation enteritis. Am J Physiol Gastrointest Liver Physiol 2004; 287: G875-885
20. MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 1988; 167: 1341-1349
21. Pender SL, Lionetti P, Murch SH, Wathan N, MacDonald TT. Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation. Gut 1996; 39: 284-290
22. De Winter H, Elewaut D, Turovskaya O, Huflejt M, Shimeld C, Hagenbaugh A, Binder S, Takahashi I, Kronenberg M, Cheroutre H. Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice. Gastroenterology 2002; 122: 1829-1841
23. Lyscom N, Brueton MJ. Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies. Immunology 1982; 45: 775-783
24. Schuppan D, Hahn EG. MMPs in the gut: inflammation hits the matrix. Gut 2000; 47: 12-14
25. MacNaughton WK, Leach KE, Prud'homme-Lalonde L, Ho W, Sharkey KA. Ionizing radiation reduces neurally evoked electrolyte transport in rat ileum through a mast cell-dependent mechanism. Gastroenterology 1994; 106: 324-335
26. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000; 43: 801-811
27. Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 1993; 105: 1323-1332
28. Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 2003; 162: 597-608
29. Ruifrok AC, Mason KA, Lozano G, Thames HD. Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment. Radiat Res 1997; 147: 1-12
30. Wang J, Zheng H, Sung CC, Richter KK, Hauer-Jensen M. Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. Am J Pathol 1998; 153: 1531-1540
31. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ, Angel P, Heath JK. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. Embo 11987; 6: 1899-1904
32. Overall CM, Wrana JL, Sodek J. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J Biol Chem 1991; 266: 14064-14071
33. Vassalli JD, Sappino AP, Belin D. The plasminogen activator/plasmin system. J Clin Invest 1991; 88: 1067-1072
34. Rao JS, Rayford A, Yamamoto M, Ang KK, Tofilon P, Sawaya R. Modulation of fibrinolysis by ionizing radiation. J Neurooncol 1994; 22: 161-171
35. Boothman DA, Wang M, Lee SW. Induction of tissue-type plasminogen activator by ionizing radiation in human malignant melanoma cells. Cancer Res 1991; 51: 5587-5595
36. Sawaya R, Rayford A, Kono S, Ang KK, Feng Y, Stephens LC, Rao JS. Elevated levels of plasminogen activators in the pathogenesis of delayed radiation damage in rat cervical spinal cord in vivo. Radiat Res 1994; 138: 386-391
37. von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S. Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 2000; 47: 63-73
38. Wang Z, Juttermann R, Soloway PD. TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem 2000; 275: 26411-26415
39. Werb Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell 1997; 91: 439-442