Cytotoxicity of novel derivatives of the spin trap EMPO

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 3, 2006, Pages 541-546

  Rohr Udilova, Nataliya ^a   Stolze, Klaus ^a   Marian, Brigitte ^b   Nohl, Hans ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cytotoxicity; ESR; Free radicals; Oxidative stress; Spin traps; Superoxide

Indexed keywords

5 (4 PROPOXYCARBONYL) 5 METHYL 1 PYRROLINE N OXIDE; 5 (ETHOXYCARBONYL) 5 METHYL 1 PYRROLINE N OXIDE; 5 (ISOPROPOXYCARBONYL) 5 METHYL 1 PYRROLINE N OXIDE; 5 (N BUTOXYCARBONYL) 5 METHYL 1 PYRROLINE N OXIDE; 5 (SEC BUTOXYCARBONYL) 5 METHYL 1 PYRROLINE N OXIDE; 5 (TERT BUTOXYCARBONYL) 5 METHYL 1 PYRROLINE N OXIDE; 5 DIETHOXYPHOSPHORYL 5 METHYL 1 PYRROLINE 1 OXIDE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CYTOTOXIC AGENT; GLUTATHIONE; LACTATE DEHYDROGENASE; PYRROLINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COUNT; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; ELECTRON SPIN RESONANCE; ENZYME RELEASE; HUMAN; HUMAN CELL; NECROSIS; SPIN TRAPPING;

BREAST NEOPLASMS; CELL DEATH; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; FIBROBLASTS; FREE RADICALS; HUMANS; LUNG NEOPLASMS; PYRROLES; SPIN LABELS; SPIN TRAPPING; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 29544435383     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.060     Document Type: Article

References (32)

1. H. Nohl, K. Staniek, and L. Gille Exp. Gerontol. 32 1997 485
2. H. Nohl Br. Med. Bull. 49 1993 653
3. K.P. Pavlick, F.S. Laroux, J. Fuseler, R.E. Wolf, L. Gray, and J. Hoffman Free Radical Biol. Med. 33 2002 311
4. S.P. Hussain, L.J. Hofseth, and C.C. Harris Nat. Rev. Cancer 3 2003 276
5. J. Rodrigo, A.P. Fernández, J. Serrano, M.A. Peinado, and A. Martínez Free Radical Biol. Med. 39 2005 26
6. P.J. Crack, and J.M. Taylor Free Radical Biol. Med. 38 2005 1433
7. Halliwell, B. M.; Gutteridge, J. M. C., Eds. Free Radicals in Biology and Medicine, 3rd ed.; Oxford Science Publication: Oxford, 1999.
8. G.R. Buettner, and L.W. Oberley Biochem. Biophys. Res. Commun. 83 1978 69
9. G. Olive, A. Mercier, F. LeMoigne, A. Rockenbauer, and P. Tordo Free Radical Biol. Med. 28 2000 403
10. H. Zhang, J. Joseph, J. Vasquez-Vivar, H. Karoui, C. Nsanzumuhire, and P. Martásek FEBS Lett. 473 2000 58
11. K. Stolze, N. Udilova, and H. Nohl Biol. Chem. 383 2002 813
12. C. Fréjaville, H. Karoui, B. Tuccio, F. Le Moigne, M. Culcasi, and S. Pietri J. Med. Chem. 38 1995 258
13. S. Barbati, J.L. Clément, G. Olive, V. Roubaud, B. Tuccio, and P. Tordo F. Minisci Free Radicals in Biology and Environment 1997 Kluwer Academic The Netherlands
14. K. Stolze, N. Udilova, and H. Nohl Free Radical Biol. Med. 29 2000 1005
15. K. Stolze, N. Udilova, T. Rosenau, A. Hofinger, and H. Nohl Biol. Chem. 384 2003 493
16. W. Berger, L. Elbling, and M. Micksche Int. J. Cancer 88 2000 293
17. J. Kerr, A. Wyllie, and A. Currie Br. J. Cancer 26 1972 239
18. N. Khan, C.M. Wilmot, G.M. Rosen, E. Demidenko, J. Sun, and J. Joseph Free Radical Biol. Med. 34 2003 1473
19. J. Fuchs, N. Groth, and T. Herrling Toxicology 151 2000 55
20. E.A. Konorev, J.E. Baker, J. Joseph, and B. Kalyanaraman Free Radical Biol. Med. 14 1993 127
21. R.F. Haseloff, K. Mertsch, E. Rohde, I. Baeger, I.A. Grigor'ev, and I.E. Blasig FEBS Lett. 418 1997 73
22. E.G. Janzen, J.L. Poyer, C.F. Schaefer, P.E. Downs, and C.M. DuBose J. Biochem. Biophys. Methods 30 1995 239
23. C.F. Schaefer, E.G. Janzen, M.S. West, J.L. Poyer, and S.D. Kosanke Free Radical Biol. Med. 21 1996 427
24. H. Zhao, J. Joseph, H. Zhang, H. Karoui, and B. Kalyanaraman Free Radical Biol. Med. 31 2001 599
25. U. Rauen, B. Elling, E.R. Gizewski, H.G. Korth, R. Sustmann, and H. de Groot Free Radical Biol. Med. 22 1997 17
26. A. Tosaki, I.E. Blasig, T. Pali, and B. Ebert Free Radical Biol. Med. 8 1990 363
27. C.E. Thomas, D.F. Ohlweiler, A.A. Carr, T.R. Nieduzak, D.A. Hay, and G. Adams J. Biol. Chem. 271 1996 3097
28. J.M. Carney, and R.A. Floyd J. Mol. Neurosci. 3 1991 47
29. S.M. Langley, P.J. Chai, J.J. Jaggers, and R.M. Ungerleider J. Thorac. Cardiovasc. Surg. 119 2000 305
30. J.B. Schulz, N. Panahian, Y.I. Chen, M.F. Beal, M.A. Moskowitz, and B.R. Rosen Am. J. Physiol. 272 1997 H1986
31. J.W. Phillis, and C. Clough-Helfman Neurosci. Lett. 116 1990 315
32. H. Pogrebniak, W. Matthews, J. Mitchell, A. Russo, A. Samuni, and H. Pass J. Surg. Res. 50 1991 469