The free radical spin trap α-phenyl-tert-butyl nitrone attenuates the cerebral response to deep hypothermic ischemia

Journal of Thoracic and Cardiovascular Surgery

Volumn 119, Issue 2, 2000, Pages 305-313

  Langley, Stephen M ^a   Chai, Paul J ^a   Jaggers, James J ^a   Ungerleider, Ross M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; PLACEBO; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL GANGLION; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; BRAIN STEM; BRAIN VASCULAR RESISTANCE; CARDIOPULMONARY BYPASS; CEREBELLUM; CONTROLLED STUDY; HEART ARREST; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROFOUND INDUCED HYPOTHERMIA; REPERFUSION INJURY; SPIN TRAPPING; SWINE; SYSTEMIC VASCULAR RESISTANCE;

EID: 0033974537     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(00)70186-3     Document Type: Article

References (29)

1. EG Janzen BJ. Blackburn Detection and identification of short-lived free radicals by an electron spin resonance trapping technique J Am Chem Soc 90 1968 5909 5910
2. JM Carney RA. Floyd Protection against oxidative damage to CNS by alpha-phenyl- tert -butyl nitrone (PBN) and other spin-trapping agents: a novel series of nonlipid free radical scavengers J Mol Neurosci 3 1991 47 57
3. C Clough-Helfman JW. Phillis The free radical trapping agent N- tert -butyl-alpha-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils Free Radic Res Com 15 1991 177 186
4. P Grammas GJ Liu K Wood RA. Floyd Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels Free Radic Biol Med 14 1993 553 557
5. PH Chan JW Schmidley RA Fishman SM. Longar Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals Neurology 34 1984 315 320
6. 2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins Am J Physiol 251 1986 H693 H699
7. +)-Cl- cotransporter activities in vascular endothelial cells Am J Physiol 263 1992 H96 H102
8. AC Gasic G McGuire S Krater AI Farhood MA Goldstein CW Smith Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence Circulation 84 1991 2154 2166
9. MD Ginsberg BD Watson R Busto S Yoshida R Prado H Nakayama Peroxidative damage to cell membranes following cerebral ischemia. A cause of ischemic brain injury? Neurochem Pathol 9 1988 171 193
10. JW. Schmidley Free radicals in central nervous system ischemia Stroke 21 1990 1086 1090
11. BK Siesjo CD Agardh F. Bengtsson Free radicals and brain damage Cerebrovasc Brain Metab Rev 1 1989 165 211
12. WJ Greeley RM Ungerleider LR Smith JG. Reves The effects of deep hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral blood flow in infants and children J Thorac Cardiovasc Surg 97 1989 737 745
13. MA Heymann BD Payne JI Hoffman AM. Rudolph Blood flow measurements with radionuclide-labeled particles Prog Cardiovasc Dis 20 1977 55 79
14. SS Tsui PM Kirshbom MJ Davies MT Jacobs WJ Greeley FH Kern Nitric oxide production affects cerebral perfusion and metabolism after deep hypothermic circulatory arrest Ann Thorac Surg 61 1996 1699 1707
15. B Hallgren P. Sourander The effect of age on the non-haemin iron in the human brain J Neurochem 2 1958 41 51
16. MM Zaleska RA. Floyd Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron Neurochem Res 10 1985 397 410
17. AA Rosenberg E Murdaugh CW. White The role of oxygen free radicals in postasphyxia cerebral hypoperfusion in newborn lambs Pediatr Res 26 1989 215 219
18. K Sano T Asano T Tanishima T. Sasaki Lipid peroxidation as a cause of cerebral vasospasm Neurol Res 2 1980 253 272
19. O Inanami M. Kuwabara Alpha-phenyl N- tert -butyl nitrone (Pbn) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats Free Radic Res 23 1995 33 39
20. JB Schulz N Panahian YI Chen MF Beal MA Moskowitz BR Rosen Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques Am J Physiol 272 1997 H1986 H1995
21. J Folbergrova Q Zhao K Katsura BK. Siesjo N- tert -butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia Proc Nat Acad Sci U S A 92 1995 5057 5061
22. S Kuroda K Katsura L Hillered TE Bates BK. Siesjo Delayed treatment with alpha-phenyl-N- tert -butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat Neurobiol Dis 3 1996 149 157
23. X Cao JW. Phillis Alpha-phenyl- tert -butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia Brain Res 644 1994 267 272
24. JW Phillis C. Clough-Helfman Protection from cerebral ischemic injury in gerbils with the spin trap agent N- tert -butyl-alpha-phenylnitrone (PBN) Neurosci Lett 116 1990 315 319
25. TL Yue JL Gu PG Lysko HY Cheng FC Barone G. Feuerstein Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons Brain Res 574 1992 193 197
26. S Bradamante E Monti L Paracchini E Lazzarini F. Piccinini Protective activity of the spin trap tert -butyl-alpha-phenyl nitrone (PBN) in reperfused rat heart J Mol Cell Cardiol 24 1992 375 386
27. DJ Hearse A. Tosaki Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart Circ Res 60 1987 375 383
28. T Sata E Kubota HP Misra M Mojarad H Pakbaz SI. Said Paraquat-induced lung injury: prevention by N- tert -butyl-alpha-phenylnitrone, a free-radical spin-trapping agent Am J Physiol 262 1992 L147 L152
29. J Pedraza-Chaverri E Tapia N. Bobadilla Ischemia-reperfusion induced acute renal failure in the rat is ameliorated by the spin-trapping agent alpha-phenyl-N- tert -butyl nitrone (PBN) Ren Fail 14 1992 467 471