Decreased nicotinic receptors in PC12 cells and rat brains influenced by fluoride toxicity - A mechanism relating to a damage at the level in post-transcription of the receptor genes

Toxicology

Volumn 200, Issue 2-3, 2004, Pages 169-177

  Shan, Ke Ren ^a   Qi, Xiao Lan ^a   Long, Yi Guo ^a   Nordberg, Agneta ^b   Guan, Zhi Zhong ^a,b  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Fluoride toxicity; mRNA; Nicotinic acetylcholine receptor; Oxidative stress; PC12 cells; Rat brains

Indexed keywords

ANTIOXIDANT; FLUORIDE; LIPID; MESSENGER RNA; NICOTINIC RECEPTOR; NITROBLUE TETRAZOLIUM; RECEPTOR SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; CELL STRAIN; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FLUORIDATION; FLUOROSIS; LIPID PEROXIDATION; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; RECEPTOR GENE; TRANSCRIPTION TERMINATION;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; BRAIN CHEMISTRY; CELL SURVIVAL; FEMALE; FLUORIDES; LIPID PEROXIDATION; MALE; NUCLEASE PROTECTION ASSAYS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PC12 CELLS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; RNA, MESSENGER; TETRAZOLIUM SALTS; THIAZOLES; VITAMIN E;

EID: 2942735016     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.03.013     Document Type: Article

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