Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride

Toxicology

Volumn 183, Issue 1-3, 2003, Pages 235-242

  Chen, Jia ^a   Shan, Ke Ren ^a   Long, Yi Guo ^a   Wang, Ya Nan ^a   Nordberg, Agneta ^b   Guan, Zhi Zhong ^a,b  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Fluoride; Nicotinic acetylcholine receptors; PC12 cells; Toxicity

Indexed keywords

ALPHA BUNGAROTOXIN; EPIBATIDINE; FLUORIDE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; BLOTTING, WESTERN; BUNGAROTOXINS; CELL MEMBRANE; KINETICS; NICOTINIC AGONISTS; PC12 CELLS; PYRIDINES; RATS; RECEPTORS, NICOTINIC; SODIUM FLUORIDE;

EID: 0037291513     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00551-6     Document Type: Article

References (27)

1. Anonymous Editorial Review, 1978. Nonskeletal fluorosis. Fluoride 11, 111-114.
2. Couturier S., Bertrand D., Matter J.M., Hernandez M.C., Bertrand S., Millar N., Valera S., Barkas T., Ballivet M. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX. Neuron. 5:1990;847-856.
3. Du L., Wang S.W., Liu J.L. The effect of fluorine on the developing human brain. Chin. J. Pathol. (Chinese). 21:1992;218-220.
4. Geeraerts F., Gijs G., Finne E., Crokaert R. Kinetics of fluoride penetration in liver and brain. Fluoride. 19:1986;108-112.
5. Gerzanich V., Peng X., Wang F., Wells G., Anand R., Fletcher S., Lindstrom J. Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol. Pharmacol. 48:1995;774-782.
6. Gotti C., Fornasari D., Clementi F. Human neuronal nicotinic receptors. Prog. Neurobiol. 53:1997;199-237.
7. Guan Z.Z., Wang Y.N., Xiao K.Q., Dai D.Y., Chen Y.H., Liu J.L., Sinderlar P., Dallner G. Influence of chronic fluorosis on membrane lipids in rat brain. Neurotoxicol. Teratol. 20:1998;537-542.
8. Guan Z.Z., Yu Y.L., Liu J.L. A study on the histopathology of the brain of the offspring from rats with chronic fluorosis. Chin. J. Pathol. (Chinese). 4:1986;297-301.
9. Guan Z.Z., Zhang X., Mousavi M., Tian J.Y., Unger C., Nordberg A. Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells. J. Neurosci. Res. 66:2001;551-558.
10. Guan Z.Z., Zhang X., Ravid R., Nordberg A. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J. Neurochem. 74:2000;237-243.
11. Jones S., Sudweeks S., Yakel J.L. Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci. 22:1999;555-561.
12. Kaneko S., Maeda T., Kume T., Kochiyama H., Akaike A., Shimohama S., Kimura J. Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors. Brain Res. 765:1997;135-140.
13. Li X.S., Zhi J.L., Gao R.O. Effect of fluoride exposure on intelligence in children. Fluoride. 28:1995;189-192.
14. Li Y., Li X., Wei S. Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism. Acta Hauxi Med. Univ. (Chinese). 252:1994;188-191.
15. Li Y., King M.A., Meyer E.M. Alpha7 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells. Brain Res. 861:2000;165-167.
16. Liu W.X., Dong Z., Liu J.L. Experimental study of behavior and cerebral morphology of rat pups generated by fluorotic female rat. Chin. J. Pathol. (Chinese). 18:1989;290-292.
17. Long, Y.G., Wang, Y.N., Chen, J., Jiang, S.F., Nordberg, A., Guan, Z.Z. Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain. Neurotoxicol. Teratol. in press.
18. Meyer E.M., Tay E.T., Papke R.L., Meyers C., Huang G.L., de Fiebre C.M. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res. 768:1997;49-56.
19. Miao H., Liu C., Bishop K., Gong Z.H., Nordberg A., Zhang X. Nicotine exposure during a critical period of development leads to persistent changes in nicotinic acetylcholine receptors of adult rat brain. J. Neurochem. 70:1998;752-762.
20. Mulienix P.J., Denbesten P.K., Schunior A., Kernan W.J. Neurotoxicity of sodium fluoride in rats. Neurotoxicol. Teratol. 17:1995;169-177.
21. Nordberg A. Human nicotinic receptors - their role in aging and dementia. Neurochem. Int. 25:1994;93-97.
22. Paterson D., Nordberg A. Neuronal nicotinic receptors in the human brain. Prog. Neurobiol. 61:2000;75-111.
23. Seguela P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.K. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;596-604.
24. Shimohama S., Greenwald D.L., Shafron D.H., Akaika A., Maeda T., Kaneko S., Kimura J., Simpkins C.E., Day A.L., Meyer E.M. Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage. Brain Res. 779:1998;359-363.
25. Svensson A.L., Nordberg A. Beta-estradiol attenuates amyloid beta-peptide toxicity via nicotinic receptors. Neuroreport. 10:1999;3485-3489.
26. Whitford G.M., Pashley D.H., Reynold K.E. Fluoride tissue distribution: short-term kinetics. Am. J. Physiol. 236:1979;141-148.
27. Zahvoronkov A.A., Strochkova L.S. Fluorosis: geographical pathology and some experimental findings. Fluoride. 14:1981;183-191.