Identification of a stretch of six divergent amino acids on the α5 helix of Gα16 as a major determinant of the promiscuity and efficiency of receptor coupling

Biochemical Journal

Volumn 380, Issue 2, 2004, Pages 361-369

  Ho, Maurice K C ^a   Chan, Jasmine H P ^a   Wong, Cecilia S S ^a   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

G protein; G16; Phospholipase C; Receptor coupling; Site directed mutagenesis

Indexed keywords

AMINO ACIDS; GENETIC ENGINEERING; PHOSPHATES; PROTEINS;

MUTATION; RECEPTOR RECOGNITION;

BIOCHEMISTRY;

AMINO ACID DERIVATIVE; CALCIUM ION; INOSITOL PHOSPHATE; ISOLEUCINE; LEUCINE; MUTANT PROTEIN;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; MOLECULAR CLONING; MUTATION; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS;

ANIMALIA; CHIMAERIFORMES;

EID: 2942714941     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040231     Document Type: Article

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